DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and MEGF10

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_016865476.1	Gene:	MEGF10 / 84466	HGNCID:	29634	Length:	1195	Species:	Homo sapiens

Alignment Length:	1242	Identity:	295/1242 - (23%)
Similarity:	398/1242 - (32%)	Gaps:	458/1242 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 LSDPGVGAIVLPFTFRWTKSFTLILQALDMYNTSYPDAERLIEETSYSGVILPSPEW-KTLDHIG 227
            |.||.|.:       .| :|:::.:|      .|||.....|..||.:.::    .| |...|
Human    83 LEDPNVCS-------HW-ESYSVTVQ------ESYPHPFDQIYYTSCTDIL----NWFKCTRH-- 127

  Fly   228 RNARITYRVRVQCAVTYYNTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCD 292
               |::||      ..|.:...|.:.|......|.|..|    ::|:          ..|...|
Human   128 ---RVSYR------TAYRHGEKTMYRRKSQCCPGFYESG----EMCV----------PHCADKC- 168

  Fly   293 PVHGKCDRPGECECRPGWRGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTH 357
             |||:|..|..|:|.|||.|..|:          .:|:|..|...|.:.     |.
Human   169 -VHGRCIAPNTCQCEPGWGGTNCS----------SACDGDHWGPHCTSR-----CQ--------- 208

  Fly   358 EPCKHGGTCENTAPDKYRCTCAEGLSGEQCE------IVEHPCATR-PCRNGGTCTLKTSNRTQA 415
              ||:|..|.   |....|.||.|..|.:||      ...:.|..| .|:||.||
Human   209 --CKNGALCN---PITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATC---------- 258

  Fly   416 QVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAA 480
                                     ||:..|                             |.|..
Human   259 -------------------------DHVTGE-----------------------------CRCPP 269

  Fly   481 GWTGPTCEINIDECAGG----------PCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAP 535
            |:||..||   |.|..|          ||::||.|..:.|  .|.||..|.|.||
Human   270 GYTGAFCE---DLCPPGKHGPQCEQRCPCQNGGVCHHVTG--ECSCPSGWMGTVC---------- 319

  Fly   536 HSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKE 600
                                                                 .||      |.|
Human   320 -----------------------------------------------------GQP------CPE 325

  Fly   601 GWGGVTCAENLDDCVGQCRNGATCIDLVNDYRCACASGFKGRDCETDIDEC----------ATSP 655
            |..|..|::   :|  ||.||.|| |.... :|.|:.|:.|..|:   |||          .|..
Human   326 GRFGKNCSQ---EC--QCHNGGTC-DAATG-QCHCSPGYTGERCQ---DECPVGTYGVLCAETCQ 380

  Fly   656 CRNGGECVDMVGKFNCICPLGYSGSLCE---------------------EAKENCTPSPCLEGHC 699
            |.|||:|..:.|.  |:|..|::|..||                     |...:|.|   :.|.|
Human   381 CVNGGKCYHVSGA--CLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHP---MSGEC 440

  Fly   700 LNTP--EGYYCH--CPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTRK 760
            ...|  .|.||:  |.|...|:.|:|   :||   |..|        ....:.|...|.|...:
Human   441 ACKPGWSGLYCNETCSPGFYGEACQQ---ICS---CQNG--------ADCDSVTGKCTCAPGFK- 490

  Fly   761 MAKPSGLPCSGHGSCEMSDVGTFCKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECM 825
                 |:.||  ..|.:...|..|....|                 |:|..:|...||  :|.|.
Human   491 -----GIDCS--TPCPLGTYGINCSSRCG-----------------CKNDAVCSPVDG--SCTCK 529

  Fly   826 SGWTGKRCSERAT------GC-YAGQCQNGGTCMPGAPDKALQPHCRCAPGWT------------ 871
            :||.|..||.|..      || ...||.|||.|      ..|...|.|||||.
Human   530 AGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGAC------NTLDGTCTCAPGWRGEKCELPCQDGT 588

  Fly   872 -GLFCAEAIDQCRGQPCH-NGGTCESGAGW--FRC--VCAQGFSGPDCRI-----NVNECSPQPC 925
             ||.|||..|......|| ..|.|....||  ..|  |||:|..||:|.:     |...|||.
Human   589 YGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPD-- 651

  Fly   926 QGGATCIDGIGGYSC--ICPPGRHGLRCEILLSDPKSACQNASNTISPYTALNRSQNWLDIALTG 988
            .|...|..|..|.:|  ||.||.:|.||    |.....|.::|......|.|      .| .|.|
Human   652 DGICECAPGFRGTTCQRICSPGFYGHRC----SQTCPQCVHSSGPCHHITGL------CD-CLPG 705

  Fly   989 RTEDDENCNACVCENGT--SRCTNLWCGLPNCYKVDPLSKSSN-----LSGVCKQHEVCVPA-LS 1045
            .|  ...||. ||.:|.  ..|..: |...|....:|:.:|..     :...|.|  .|.|| ..
Human   706 FT--GALCNE-VCPSGRFGKNCAGI-CTCTNNGTCNPIDRSCQCYPGWIGSDCSQ--PCPPAHWG 764

  Fly  1046 ETCLSSPCNVRGD--CRALEPSRRVAP--------PRLPAKSSCWPNQAVVNENCARLTILLALE 1100
            ..|:.: ||....  |.|.:...:..|        .|.|.        ....::||.:.
Human   765 PNCIHT-CNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPL--------GFYGKDCALIC------ 814

  Fly  1101 RVGKGAS---VEGLCSLVRVLLAAQLIKK-PASTFGQDPGMLMVLCD-LKTGTNDTVELTVSSS- 1159
            :...||.   :.|.|:.....:.....:| |:.|:|..   ...:|| |...|.|.:..|...|
Human   815 QCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYG---CRQICDCLNNSTCDHITGTCYCSP 876

  Fly  1160 ----KLNDPQLPVAVGLLGELLSFRQLNGIQRRKELELQHAKLAALTSIVEVKLETARVADGSGH 1220
                ...|....:.||         .||.:.|              ||       ||..||....
Human   877 GWKGARCDQAGVIIVG---------NLNSLSR--------------TS-------TALPADSYQI 911

  Fly  1221 SLLIGVLCGVFIVLVGFSVFISLYWKQRLAYRTSSGMNLTPSLDALRHEEEKSNNLQNEE----N 1281
            ..:.|::..|.:||...::||....||:....:...:..||::..:..:...|..|.:..    |
Human   912 GAIAGIIILVLVVLFLLALFIIYRHKQKGKESSMPAVTYTPAMRVVNADYTISGTLPHSNGGNAN 976

  Fly  1282 LRRYTNP 1288
            ...:|||
Human   977 SHYFTNP 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722	13/62 (21%)
		EGF_CA	350..388	CDD:238011	10/37 (27%)
		EGF_CA	490..526	CDD:238011	15/45 (33%)
		EGF_CA	610..645	CDD:238011	12/34 (35%)
		EGF_CA	647..683	CDD:238011	14/45 (31%)
		EGF_CA	798..833	CDD:238011	10/34 (29%)
		EGF_CA	879..913	CDD:238011	14/38 (37%)
		EGF_CA	916..952	CDD:238011	15/37 (41%)
		VWC_out	<993..1053	CDD:214565	16/67 (24%)
MEGF10	XP_016865476.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910