DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ser and Fbn1

DIOPT Version :9

Sequence 1:NP_001287558.1 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster
Sequence 2:NP_114013.2 Gene:Fbn1 / 83727 RGDID:620908 Length:2872 Species:Rattus norvegicus


Alignment Length:1380 Identity:332/1380 - (24%)
Similarity:473/1380 - (34%) Gaps:486/1380 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    97 NSHLLNGYC----------CGMPAELRATKTIGCSPCTTAFR-LCLKEYQT--------TEQGAS 142
            :|..:||.|          |...:.|..||||    |....: .|   :||        ...||:
  Rat   814 SSPCINGVCKNSPGSFICECSPESTLDPTKTI----CIETIKGTC---WQTVIDGRCEININGAT 871

  Fly   143 ISTGC--SFGNATTKILGGSSFVLS--DPGVGAIVLPFTFRWTKSFTLI--LQALDMYNTS-YPD 200
            :.:.|  |.|.|     .||...:.  ||..|           |.::.|  .|..|:.... :|.
  Rat   872 LKSECCSSLGAA-----WGSPCTICQVDPICG-----------KGYSRIKGTQCEDINECEVFPG 920

  Fly   201 AERLIEETSYSGVILPS--------PEWKTLDHIGRNARITYRVRVQ-CAVTYYNTTCT--TFCR 254
            ..:       :|:.:.|        |...|||..|   ||...:|:: |.:.|.:..||  ...|
  Rat   921 VCK-------NGLCVNSRGSFKCECPSGMTLDATG---RICLDIRLETCFLKYDDEECTLPIAGR 975

  Fly   255 PRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWR-------G 312
            .|.|.    .|.|.|.     .|....|||.       |:....:....|...||:.       .
  Rat   976 HRMDA----CCCSVGA-----AWGTEECEEC-------PLRNSREYEELCPRGPGFATKDITNGK 1024

  Fly   313 PL---CNECMVYPG-CKHGSCNGS--AWKCVCDTNWGGILCDQDLNFCGTHEPCKHG------GT 365
            |.   .|||.:.|. |.||.|..:  ::||.||:   |...|.:...|...:.|:..      |.
  Rat  1025 PFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDS---GFALDSEERNCTDIDECRISPDLCGRGQ 1086

  Fly   366 CENTAPDKYRCTCAEGL-SG----EQCEIVEHPCATRP--CRNGGTCTLKTSNRTQAQVYRTSHG 423
            |.|| |..:.|.|.||. ||    :.|..::. |...|  || ||.|     :.|:.. ||..  
  Rat  1087 CVNT-PGDFECKCDEGYESGFMMMKNCMDIDE-CQRDPLLCR-GGIC-----HNTEGS-YRCE-- 1140

  Fly   424 RSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPD---------FTCDCA 479
                                .|.|..|:.:.| ..:.:...:|...|.|.         :.|.|.
  Rat  1141 --------------------CPSGHQLSPNIS-ACIDINECELSANLCPSGRCVNLIGKYQCACN 1184

  Fly   480 AGWTGPTCE----INIDECA--GGPCE-------------------------------------- 500
            .|: .||.:    ::||||:  .|.||                                      
  Rat  1185 PGY-HPTHDRLFCVDIDECSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRSCTDIDECEDNPN 1248

  Fly   501 --HGGTCIDLIGGFRCEC----------------------PPEWHGDVCQ--------------- 526
              .||.|.::.|.:||.|                      |.......|:               
  Rat  1249 ICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYS 1313

  Fly   527 --------VDVNECE-APHSAGIAANALLTTTATAI--------IGSNLSSTALLAALTSAVAST 574
                    .|:|||| ..|:.|  .:|:.|.||.:.        ||..:..|.|        ...
  Rat  1314 GKKGKTGCTDINECEIGAHNCG--RHAVCTNTAGSFKCSCSPGWIGDGIKCTDL--------DEC 1368

  Fly   575 SLAIGPCINAKECRNQPGSFACICKEGW--GGVTCAENLDDC---VGQCRNGATCIDLVNDYRCA 634
            |.....|....:|:|..||:.|:||:|:  .|.||.: ||:|   :..|.|| .|::....|||.
  Rat  1369 SNGTHMCSQHADCKNTMGSYRCLCKDGYTGDGFTCTD-LDECSENLNLCGNG-QCLNAPGGYRCE 1431

  Fly   635 CASGF----KGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGY----SGSLCEEAKENCTP 691
            |..||    .|:.|| ||:||:.......|.|.::.|.|.|.|.:||    ||..|.:..|...|
  Rat  1432 CDMGFVPSADGKACE-DINECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDP 1495

  Fly   692 SPCLEGHCLNTPEGYYCHCPPD-------------RAGKHCEQLRP-------LCSQPPCNE--- 733
            :.|:.|:|:|||..|.|.||||             |:|.....:||       .||    ||   
  Rat  1496 TTCISGNCVNTPGSYTCDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACS----NEIGV 1556

  Fly   734 -----GCFANVSLATSATTTTTTTTTATTTRKMAKPSG--------------------LP--CSG 771
                 .|..::..|. .|.........|:..|:..|.|                    ||  |.|
  Rat  1557 GVSKASCCCSLGKAW-GTPCELCPPVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQG 1620

  Fly   772 HGSCEMSDVGTF-CKCHVGH----TGTFCEHNLNEC-SPNPCRNGGICLDGDGDFTCECMSGWT- 829
             |.| ::..|:| |:|..|:    ....|: ::||| :|..| ..|.|.:..|::||.|...:. 
  Rat  1621 -GKC-INTFGSFQCRCPTGYYLNEDTRVCD-DVNECETPGIC-GPGTCYNTVGNYTCICPPDYMQ 1681

  Fly   830 ---GKRCSE-RATGCYAGQCQNGGTCMPGAPDKALQPHCRCA----------------------- 867
               |..|.: |.:.||.....:..||.........:..|.|:                       
  Rat  1682 VNGGNNCMDMRRSLCYRNYHADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFA 1746

  Fly   868 -------PG-----WTGLFCAEAIDQCRGQP--CHNGGTCESGAGWFRCVCAQGFSGPD----CR 914
                   ||     :|||  ...||:||..|  |.| |.|.:..|.|||.|..||...|    |.
  Rat  1747 TLCGSQRPGFVIDIYTGL--PVDIDECREIPGVCEN-GVCINMVGSFRCECPVGFFYNDKLLVCE 1808

  Fly   915 INVNECSPQP-CQGGATCIDGIGGYSCICPPGRHGLRCEILLS----DPKSACQNASNTISPYTA 974
             :::||...| ||..|.||:..|.|.|.|.||..      |.|    :.::.||...|..|....
  Rat  1809 -DIDECQNGPVCQRNAECINTAGSYRCDCKPGYR------LTSTGQCNDRNECQEIPNICSHGQC 1866

  Fly   975 LNRSQNWLDIALTG-RTEDDE-------NCNACVCENGTSRCT----NLWCG-------LPNCYK 1020
            ::...::..:..|| :|..|:       .|....|.|||.|.|    |..|.       ..:|..
  Rat  1867 IDTVGSFYCLCHTGFKTNADQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCID 1931

  Fly  1021 VDPLSK-SSNL--SGVC------------KQHEV------CVPALSETCLSSP--CNVRGDCRAL 1062
            ||..:. :.||  :|.|            :.:||      ||. ::| |:..|  | ..|.|:.|
  Rat  1932 VDECATGNGNLCRNGQCVNTVGSFQCRCNEGYEVAPDGRTCVD-INE-CVLDPGKC-APGTCQNL 1993

  Fly  1063 EPSRRVAPPRLPAKSSCWPNQAVVNENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKP 1127
            :.|.|..         |.|..::.|:.|         |.:.:......:|:|             
  Rat  1994 DGSYRCI---------CPPGYSLQNDKC---------EDIDECVEEPEICAL------------- 2027

  Fly  1128 ASTFGQDPGMLMVLC 1142
             .|.....|....||
  Rat  2028 -GTCSNTEGSFKCLC 2041

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SerNP_001287558.1 MNNL 83..161 CDD:284966 21/84 (25%)
DSL 220..282 CDD:279722 18/64 (28%)
EGF_CA 350..388 CDD:238011 13/48 (27%)
EGF_CA 490..526 CDD:238011 15/99 (15%)
EGF_CA 610..645 CDD:238011 14/41 (34%)
EGF_CA 647..683 CDD:238011 14/39 (36%)
EGF_CA 798..833 CDD:238011 12/39 (31%)
EGF_CA 879..913 CDD:238011 17/39 (44%)
EGF_CA 916..952 CDD:238011 14/36 (39%)
VWC_out <993..1053 CDD:214565 24/100 (24%)
Fbn1NP_114013.2 Fibrillin_U_N 48..82 CDD:408021
TB 195..>228 CDD:395554
EGF_CA 246..>276 CDD:214542
EGF_CA 288..329 CDD:214542
TB 345..389 CDD:395554
EGF_CA 491..522 CDD:214542
EGF_CA 531..572 CDD:214542
EGF_CA 573..613 CDD:214542
EGF_CA 614..647 CDD:214542
TB 671..712 CDD:395554
EGF_CA 724..764 CDD:419698
EGF_CA 766..>797 CDD:214542
cEGF 788..811 CDD:403760
TB 863..>891 CDD:395554 8/32 (25%)
TB 968..1010 CDD:395554 13/57 (23%)
EGF_CA 1071..1105 CDD:214542 10/34 (29%)
EGF_CA 1114..1150 CDD:214542 13/65 (20%)
FXa_inhibition 1202..1237 CDD:405372 4/34 (12%)
EGF_3 1327..1362 CDD:403986 10/36 (28%)
EGF_3 1368..1403 CDD:403986 11/34 (32%)
EGF_CA 1447..1487 CDD:214542 14/39 (36%)
EGF_CA 1488..1519 CDD:214542 14/30 (47%)
TB 1550..1591 CDD:395554 9/45 (20%)
EGF_CA 1607..1639 CDD:214542 11/33 (33%)
EGF_CA 1649..1688 CDD:214542 12/39 (31%)
TB 1707..1750 CDD:395554 3/42 (7%)
EGF_CA 1767..>1798 CDD:214542 14/31 (45%)
EGF_CA 1809..1841 CDD:214542 14/31 (45%)
vWFA <1848..1887 CDD:412136 7/38 (18%)
EGF_CA 1931..1972 CDD:311536 8/40 (20%)
EGF_CA 1974..2009 CDD:238011 11/46 (24%)
EGF_CA 2014..2054 CDD:419698 6/42 (14%)
TB 2071..2113 CDD:395554
EGF_CA 2128..2166 CDD:214542
EGF_CA 2167..2206 CDD:214542
TB 2357..2392 CDD:395554
vWFA <2443..2483 CDD:412136
cEGF 2466..2489 CDD:403760
EGF_CA 2486..>2517 CDD:419698
EGF_CA 2525..2567 CDD:214542
EGF_CA 2568..>2597 CDD:214542
EGF_CA 2608..2639 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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