DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ser and SVEP1

DIOPT Version :9

Sequence 1:NP_001287558.1 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster
Sequence 2:NP_699197.3 Gene:SVEP1 / 79987 HGNCID:15985 Length:3571 Species:Homo sapiens


Alignment Length:1273 Identity:281/1273 - (22%)
Similarity:405/1273 - (31%) Gaps:482/1273 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 LESTIESADSLGMSKKTATKRQRP--RHRVPKI------ATLPSTIRDCRSLKSACNLIALILIL 75
            |::..|:|.|:|.:|.:..||..|  .:::..|      ..||....|....::...|:. .|..
Human   885 LDTVQETATSIGNAKSSRIKRSAPLSDYKIKLIFNITASVPLPDERNDTLEWENQQRLLQ-TLET 948

  Fly    76 LVHKISAAGN------FEL--EILEISNTNS---HLLNGYCCGMPAE-LRATKTIGCSPCTTAFR 128
            :.:|:....|      |:|  ||| |:::||   ...:.:|  .|.. ||....:.| |..|.:.
Human   949 ITNKLKRTLNKDPMYSFQLASEIL-IADSNSLETKKASPFC--RPGSVLRGRMCVNC-PLGTYYN 1009

  Fly   129 LCLKEYQTTEQGASISTGCSFGNATTKILGGSSFVLSDPGVGAIVLPFTFRWTKSFTLILQALDM 193
            |   |:.|.|       .|..|                                           
Human  1010 L---EHFTCE-------SCRIG------------------------------------------- 1021

  Fly   194 YNTSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYN----TTCTTFC- 253
               ||.|     ||......:.||..:....|    :|.....:.||....|:    .||.: | 
Human  1022 ---SYQD-----EEGQLECKLCPSGMYTEYIH----SRNISDCKAQCKQGTYSYSGLETCES-CP 1073

  Fly   254 ----RPRDDQFGHYAC------------GSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPG 302
                :|:   ||..:|            |:.....|     ||.|.|           ||..|.|
Human  1074 LGTYQPK---FGSRSCLSCPENTSTVKRGAVNISAC-----GVPCPE-----------GKFSRSG 1119

  Fly   303 ECECRPGWRG--------PLCNECMVY-----------PGCKHGSCNGSAWK--CVCDTNWGGIL 346
            ...|.|..|.        ..|..|..|           ..|...|...||.:  .|...:.|.|.
Human  1120 LMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIK 1184

  Fly   347 CDQDLNFCGTHE----PCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTL 407
            ...:::....||    ||.:.|||:..... |.|.|..|.:|.:||.....|:..||.|.|.|  
Human  1185 KRHEISSQVFHECFFNPCHNSGTCQQLGRG-YVCLCPLGYTGLKCETDIDECSPLPCLNNGVC-- 1246

  Fly   408 KTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAP 472
                                                                        :.|..
Human  1247 ------------------------------------------------------------KDLVG 1251

  Fly   473 DFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHS 537
            :|.|:|.:|:||..||.||:||:..||.:.|.|:|.:.|:||.|...:.|..|:.:||||::   
Human  1252 EFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQS--- 1313

  Fly   538 AGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGW 602
                                                     .||:|...|.:|.|.|.|.|..|:
Human  1314 -----------------------------------------NPCLNNAVCEDQVGGFLCKCPPGF 1337

  Fly   603 GGVTCAENLDDCVGQ-CRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMV 666
            .|..|.:|:|:|:.| |:|||||.|..|.:||.||:||.|..||.:|:||.::||||...|||.:
Human  1338 LGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDEL 1402

  Fly   667 GKFNCICPLGYSGSLCEEAK-------------------ENCTPSPCLEGHCL------------ 700
            ..::|.|..|:||..||..:                   :...||.    |.|            
Human  1403 NSYSCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVMLDGMLPSL----HALTCTFWMKSSDDM 1463

  Fly   701 --NTPEGYYCHCPPDRA--------------GKHCEQLRPLCSQPPCNEGCFANVSLATSATTTT 749
              .||..|......|..              |:     ..:.:.|..|:|.:.::::        
Human  1464 NYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGR-----EKITNCPSVNDGRWHHIAI-------- 1515

  Fly   750 TTTTTATTTRKM---AKPS--------GLPCSGHGSC----EMSDVGTFCKCHVGHTGTFCEHNL 799
             |.|:|....|:   .|.|        |||..|.|:.    |....|..........|:..:.||
Human  1516 -TWTSANGIWKVYIDGKLSDGGAGLSVGLPIPGGGALVLGQEQDKKGEGFSPAESFVGSISQLNL 1579

  Fly   800 --------------NECSPNPCRNGGICLDGDGDFTCECMSGWTGK-RCSERATGCYAGQCQN-G 848
                          ..| |.....|.:....|      .:||..|| :...::..|  ..|.. |
Human  1580 WDYVLSPQQVKSLATSC-PEELSKGNVLAWPD------FLSGIVGKVKIDSKSIFC--SDCPRLG 1635

  Fly   849 GTCMPGAPDKALQPHCRCA-----PG-WTGLFC-------AEAIDQCRGQ--------------- 885
            |:.          ||.|.|     || ...|||       ...:..|..|               
Human  1636 GSV----------PHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISC 1690

  Fly   886 ----PCHNG---------GT-----CESG---AGWFRCVCAQGFS----GPDCRINVNECS-PQP 924
                |..||         |:     |.:|   .|..|..|....|    .|.| ::|:||: ...
Human  1691 GVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSC-LDVDECAVGSD 1754

  Fly   925 CQGGATCIDGIGGYSCICPPGRHG--------LRCEILLSDPKSACQNASNTISPYTALNRSQNW 981
            |...|:|::..|.|.|.|.|...|        ::|:...:...........|:......:..:.:
Human  1755 CSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGY 1819

  Fly   982 LDIALTGRT--EDDE------NCNACVC------ENG-------------TSRCTNLWCGLPNCY 1019
            ..:.:|..|  |..|      .|.|..|      |||             |.||.       ..|
Human  1820 QLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCN-------KGY 1877

  Fly  1020 KVDPLSKSSNLSGVCKQHE--VCVPALSETCLSSPCNV 1055
            .:....:||.|:.....|.  ||.|.   .| |||.|:
Human  1878 TLAGDKESSCLANSSWSHSPPVCEPV---KC-SSPENI 1911

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SerNP_001287558.1 MNNL 83..161 CDD:284966 22/89 (25%)
DSL 220..282 CDD:279722 16/82 (20%)
EGF_CA 350..388 CDD:238011 12/41 (29%)
EGF_CA 490..526 CDD:238011 14/35 (40%)
EGF_CA 610..645 CDD:238011 19/35 (54%)
EGF_CA 647..683 CDD:238011 15/35 (43%)
EGF_CA 798..833 CDD:238011 10/49 (20%)
EGF_CA 879..913 CDD:238011 13/73 (18%)
EGF_CA 916..952 CDD:238011 12/44 (27%)
VWC_out <993..1053 CDD:214565 21/86 (24%)
SVEP1NP_699197.3 VWA 84..258 CDD:278519
GCC2_GCC3 310..360 CDD:285001
CCP 378..434 CDD:153056
CCP 438..494 CDD:153056
DUF5011 560..642 CDD:295940
DUF5011 643..722 CDD:295940
O-glycosylated at one site 887..894 2/6 (33%)
GCC2_GCC3 1005..1052 CDD:285001 16/111 (14%)
GCC2_GCC3 1059..1106 CDD:285001 9/50 (18%)
GCC2_GCC3 1113..1160 CDD:285001 10/46 (22%)
EGF 1197..1225 CDD:278437 9/28 (32%)
EGF_CA 1231..1267 CDD:238011 13/97 (13%)
EGF_CA 1269..1305 CDD:238011 14/35 (40%)
EGF_CA 1308..1342 CDD:238011 15/77 (19%)
EGF_CA 1345..1381 CDD:238011 19/35 (54%)
EGF_CA 1383..1419 CDD:238011 15/35 (43%)
LamG 1424..1622 CDD:304605 36/222 (16%)
Sushi 1628..1685 CDD:278512 15/68 (22%)
CCP 1690..1743 CDD:153056 11/52 (21%)
EGF_CA 1745..1783 CDD:214542 12/37 (32%)
PHA02927 1789..2017 CDD:222943 28/134 (21%)
CCP 1789..1843 CDD:153056 6/53 (11%)
CCP 1847..1901 CDD:153056 13/60 (22%)
CCP 1905..1958 CDD:153056 5/8 (63%)
CCP 1963..2016 CDD:153056
Sushi 2021..2078 CDD:278512
CCP 2083..2136 CDD:153056
PHA02927 2137..2376 CDD:222943
CCP 2146..2199 CDD:153056
CCP 2204..2260 CDD:153056
CCP 2264..2318 CDD:153056
CCP 2323..2377 CDD:153056
CCP 2381..2436 CDD:153056
CCP 2440..2494 CDD:153056
PHA02927 2498..2770 CDD:222943
CCP 2498..2551 CDD:214478
CCP 2556..2608 CDD:153056
CCP <2670..2713 CDD:153056
CCP 2717..2771 CDD:153056
PHA02927 2770..3003 CDD:222943
CCP 2775..2828 CDD:214478
CCP 2833..2887 CDD:153056
Cell attachment site. /evidence=ECO:0000255 2845..2847
CCP 2891..2945 CDD:153056
CCP 2949..3002 CDD:214478
Sushi 3007..3059 CDD:278512
CCP 3064..3118 CDD:153056
Sushi 3181..3231 CDD:278512
CCP 3241..3295 CDD:153056
CCP 3299..3353 CDD:153056
CCP 3357..3412 CDD:153056
CCP 3416..3469 CDD:153056
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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