DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ser and notch1b

DIOPT Version :9

Sequence 1:NP_001287558.1 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster
Sequence 2:XP_005168706.1 Gene:notch1b / 794892 ZFINID:ZDB-GENE-990415-183 Length:2482 Species:Danio rerio


Alignment Length:1093 Identity:306/1093 - (27%)
Similarity:422/1093 - (38%) Gaps:322/1093 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   141 ASISTGCSFG-NATTKILGGSSFVLSDPG-VGAIVLPFTFRWTKSFTLILQALDMYNTSYPDAER 203
            |.||..|..| |..|..:.|.:......| ||                            |..::
Zfish   372 ACISNPCQKGSNCDTNPVNGKAICTCPLGYVG----------------------------PACDQ 408

  Fly   204 LIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTC--------TTFCRPRD--- 257
            .::|.|...        ...:|.|:........:.:|...|....|        :|.|: .|   
Zfish   409 DVDECSLGA--------NPCEHAGKCINTKGSFQCKCLQGYVGARCELDINECLSTPCQ-NDATC 464

  Fly   258 -DQFGHYAC----GSEG-----------QKLCLN-----------------GWQGVNCEEAI--- 286
             ||.|.:.|    |.||           ...|||                 |:.|..|:..|   
Zfish   465 LDQIGGFHCICMPGYEGVFCQINTDECASMPCLNNGKCIDKINNYQCECPTGFSGSQCQFDIDEC 529

  Fly   287 ----CKAGCDPVHGKC-DRPG--ECECRPGWRGPLC----NECMVYPGCKHGSCNG--SAWKCVC 338
                ||.|     .|| |.|.  .|:|..|:.|..|    :||:..| |.:|:|..  :::.|||
Zfish   530 ASTPCKNG-----AKCMDGPNMYTCQCTEGYTGQHCETDVDECLSNP-CHYGTCKDGLASFTCVC 588

  Fly   339 DTNWGGILCDQDLNFCGTHEPCKHGGTCEN------------TAP-------------------- 371
            ...:.|.||:.::|.| ..:||::||||::            ||.                    
Zfish   589 RAGFMGRLCEININEC-LSQPCQNGGTCQDRENAYLCVCPKGTAGANCEINLDDCQSNPCDFGRC 652

  Fly   372 -DK---YRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRT------------QAQVYR- 419
             ||   |.|.|..|.:|:.|.|....||..||.|||||....:..|            |:|:.. 
Zfish   653 IDKINGYECACEPGYTGKMCNINIDECAINPCHNGGTCVDGVNGFTCLCREGYHDTTCQSQLNEC 717

  Fly   420 ----TSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAA 480
                ..||...                     ..:||                     :.|.|.:
Zfish   718 LSNPCIHGHCE---------------------DKVNG---------------------YNCICDS 740

  Fly   481 GWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEA----------P 535
            ||:|..|:||.:||...||.:||||.|:..|:.|.|...:.|..||.::|||.:          .
Zfish   741 GWSGVNCDINNNECESNPCMNGGTCKDMTSGYVCTCRAGFSGPNCQTNINECASNPCLNQGTCID 805

  Fly   536 HSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPG--SFACIC 598
            ..||...|.||..|     |.|..:  |||...|.         ||.|...|:....  ||:|:|
Zfish   806 DVAGYKCNCLLPYT-----GENCET--LLAPCGSK---------PCKNGGVCKESEDYESFSCVC 854

  Fly   599 KEGWGGVTCAENLDDCV-GQCRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGEC 662
            ..||.|.||..::::|| ..|||.|.|.:.:..|:|:|.:|:.||:||||||:|..:||.|||.|
Zfish   855 PAGWQGQTCEVDINECVKNPCRNDAICQNSIGSYKCSCKAGYTGRNCETDIDDCKPNPCSNGGFC 919

  Fly   663 VDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLEG-HCLNTPEGYYCHCPPDRAGKHCEQLRPLC 726
            .|.|..|.|.|..|:.|..|||....|..:||..| :|.:....|.|.|||..:|.|||...|.|
Zfish   920 KDAVNAFACTCLPGFRGGRCEEDINECESNPCKNGANCTDCVNSYTCTCPPGFSGIHCENNTPDC 984

  Fly   727 SQPPCNEG--CFANVSLATSATTTTTTTTTATTTRKMAKPSGL---------------PCSGHGS 774
            ::..|..|  |...::..|...                 |.|.               ||...|:
Zfish   985 TESSCFNGGTCVDGINSFTCLC-----------------PKGFTGNYCQHDINECDSRPCMNGGT 1032

  Fly   775 CEMSDVGTF-CKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERAT 838
            |:.| .||: |.|..|:.|..|:..:|.|.|:||:|||||......::|:|.:||||..|...:.
Zfish  1033 CQDS-YGTYKCTCPQGYHGLNCQELVNWCKPSPCKNGGICRQSGTRYSCQCQTGWTGLYCDVPSV 1096

  Fly   839 GCYAGQ----------CQNGGTCMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTC 893
            .|....          |:|.|.|:    |.....:|.|..|:||.:|.|.:|:|...||.||.||
Zfish  1097 SCEVAAKQQGVDVVRLCRNSGQCL----DAGNTHYCHCQAGYTGSYCEEQVDECIPNPCQNGATC 1157

  Fly   894 ESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICPPGRHGLRCEILLSDP 958
            ....|.:.|.|..|:.|.:|...:|||..||||.|.||||.|..|.|.||.|..|:.|||.:.| 
Zfish  1158 TDYLGGYSCECVPGYHGVNCSDEINECLSQPCQNGGTCIDLINTYKCSCPRGTQGVHCEINIDD- 1221

  Fly   959 KSACQNASNTISPYT--------ALNRSQNWLDIALTGRTEDDENCNACV---------CENGTS 1006
               |       :|:|        ..|:          ||..|......|:         ||...:
Zfish  1222 ---C-------TPFTDPITHEPKCFNQ----------GRCVDRVGGYHCICPPGYVGERCEGDVN 1266

  Fly  1007 RCTNLWCGLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDC 1059
            .|.:..||..:|.::....:....:|...||  | ..:.:.|...||...|.|
Zfish  1267 ECLSNPCGTHSCIQLKNNYRCECRTGYTGQH--C-DKVFDGCKGKPCRNGGTC 1316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SerNP_001287558.1 MNNL 83..161 CDD:284966 8/20 (40%)
DSL 220..282 CDD:279722 20/105 (19%)
EGF_CA 350..388 CDD:238011 17/73 (23%)
EGF_CA 490..526 CDD:238011 14/35 (40%)
EGF_CA 610..645 CDD:238011 13/35 (37%)
EGF_CA 647..683 CDD:238011 17/35 (49%)
EGF_CA 798..833 CDD:238011 16/34 (47%)
EGF_CA 879..913 CDD:238011 13/33 (39%)
EGF_CA 916..952 CDD:238011 19/35 (54%)
VWC_out <993..1053 CDD:214565 12/68 (18%)
notch1bXP_005168706.1 EGF_CA 175..213 CDD:238011
EGF_CA 221..252 CDD:238011
EGF_CA 254..290 CDD:238011
EGF_CA 292..329 CDD:238011
EGF_CA 332..367 CDD:238011
EGF_CA 409..447 CDD:238011 6/45 (13%)
EGF_CA 449..485 CDD:238011 10/36 (28%)
EGF_CA 487..523 CDD:238011 5/35 (14%)
EGF_CA 525..561 CDD:238011 12/40 (30%)
EGF_CA 563..598 CDD:238011 11/35 (31%)
EGF_CA 600..636 CDD:238011 10/36 (28%)
EGF_CA 638..672 CDD:238011 7/33 (21%)
EGF_CA 675..711 CDD:238011 10/35 (29%)
EGF_CA 715..747 CDD:238011 9/73 (12%)
EGF_CA 752..786 CDD:238011 13/33 (39%)
EGF_CA 788..824 CDD:238011 11/40 (28%)
EGF_CA 866..902 CDD:238011 13/35 (37%)
EGF_CA 904..940 CDD:238011 17/35 (49%)
EGF_CA 942..978 CDD:238011 12/35 (34%)
EGF_CA 985..1016 CDD:238011 6/47 (13%)
EGF_CA 1018..1054 CDD:238011 11/36 (31%)
EGF 1060..1090 CDD:278437 15/29 (52%)
EGF_CA 1143..1177 CDD:238011 13/33 (39%)
EGF_CA 1181..1216 CDD:238011 19/34 (56%)
EGF_CA 1218..1262 CDD:238011 9/64 (14%)
EGF_CA 1264..1298 CDD:238011 7/35 (20%)
EGF_CA <1309..1340 CDD:238011 4/8 (50%)
NL 1437..1473 CDD:197463
Notch 1481..1516 CDD:278494
NL 1515..1555 CDD:197463
NOD 1561..1612 CDD:284282
NODP 1667..1724 CDD:284987
Ank_2 <1867..1953 CDD:289560
ANK repeat 1874..1920 CDD:293786
ANK 1917..2029 CDD:238125
ANK repeat 1922..1953 CDD:293786
Ank_2 1927..2020 CDD:289560
ANK repeat 1955..1986 CDD:293786
ANK 1984..2108 CDD:238125
ANK repeat 1989..2053 CDD:293786
Ank_2 1994..2086 CDD:289560
ANK repeat 2055..2086 CDD:293786
DUF3454 2404..2467 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 53 1.000 Domainoid score I11360
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.810

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