Protein Alignment Ser and nell1

DIOPT Version :9

• Sequence 1: NP_001287558.1
• Gene: Ser / 43275
• FlyBaseID: FBgn0004197
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: XP_031756556.1
• Gene: nell1 / 779470
• XenbaseID: XB-GENE-920228
• Length: 829
• Species: Xenopus tropicalis
• Alignment Length: 1069
• Identity: 210/1069 - (19%)
• Similarity: 307/1069 - (28%)
• Gaps: 428/1069 - (40%)

  Fly   113 RATKTIGCSPCTTAFRLCLKEYQTTEQGASISTGCSFGNATTKILGGSSFVLSDPGVGAIVLPFT 177
            ||...:|..|......:...|...:.:|.:...|...|:.......|:..:.:.|.:...|:..
 Frog    15 RAVLGLGTDPDLQIDVITELELVNSTRGVTQVFGVHNGSKAFLFQDGAREIHAAPHMSEKVIQL- 78

  Fly   178 FRWTKSFTLILQALDMYNTSYPDAERLIEETSYSGVILPSPEWK----TLDHIGRNARITYRVRV 238
            ||....||.:..              :.:.:|.|||||...|.:    .|:..|....|.|..|
 Frog    79 FRNKSEFTFLAS--------------IQQRSSTSGVILSIREMEHSFFELESSGLRDEIRYHYR- 128

  Fly   239 QCAVTYYNTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGE 303
                  :|.      :.|.:.|.:.....:..|:.|.    |:....:....|:.::.:...|.:
 Frog   129 ------FNG------KSRTEAFPYRLADGQWHKIALT----VSASHVLLHVDCNRIYERVIDPPD 177

  Fly   304 CECRPG---WRGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGT 365
            ....||   |.|        ....|||.             :.|::.|..:.|.    |..:...
 Frog   178 ANLSPGSSLWLG--------QRNRKHGF-------------FKGVIQDVKMIFM----PNGYITQ 217

  Fly   366 CEN---TAPDKYRCTCAEGLSGEQ-----CEIVEHPCATRPCRNGGTCTLKTSNRTQAQVY---- 418
            |.|   |.|     ||::.||..|     .|::....|.....:....:| ||.|.:..::
 Frog   218 CPNLNRTCP-----TCSDFLSLVQGIMDLQELLAKMTAKLNYASKPRISL-TSQRGELHIFVKPT 276

  Fly   419 -------RTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTC 476
                   ..|.|.|...     |||.| |:||...........:|.:.||..:        |:..
 Frog   277 GMLERLTGVSDGISGAS-----SSSFR-LNHLSTGADEETIEGNPTVASLHHI--------DYPP 327

  Fly   477 DCAAGWTG------------PTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGD-VCQVD 528
            ....|..|            ||        ....|.:||..:.             .|| :....
 Frog   328 SEEMGMNGYSELLSEAKDHRPT--------EATKCIYGGKVLA-------------EGDRILTKS 371

  Fly   529 VNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPC--INAKEC-RNQ 590
            ..||:.                                     .|....:.||  :|..|. |..
 Frog   372 CRECKN-------------------------------------GSLQKLMDPCPPLNCSEADRVL 399

  Fly   591 PGSFAC-------ICKEGWGGVTCAENLDDCVGQCRNGATCIDLVNDYRCACASGFKGRD----- 643
            |.:..|       .|.:|.   .|.||     .:|||..      |...|.|.|||:...
 Frog   400 PENQCCSVCRGHNFCADGH---RCGEN-----SECRNHN------NKATCECLSGFQPIQGDPAY 450

  Fly   644 CETDIDECATSP--CRNGGECVDMVGKFNCICPLGY---------SGSLCEEAKENCTPSPCLEG 697
            || ||||||...  |.....||::.|.:.|.|..||         ....|.|.:.:|..:..
 Frog   451 CE-DIDECAAKMHYCHANTVCVNLPGSYRCDCVPGYIRVDDFSCTEHDECGEGESSCDENAI--- 511

  Fly   698 HCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTRKMA 762
             |.|:..|:.|.|.|...|.
 Frog   512 -CANSVRGHSCTCKPGYVGN--------------------------------------------- 530

  Fly   763 KPSGLPCSGHGSCEMSDVGTFCKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSG 827
                              ||.|:       .|||..
 Frog   531 ------------------GTVCR-------AFCEEG----------------------------- 541

  Fly   828 WTGKRCSERATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQ--PCHNG 890
                             |:.||||:  ||:|     |.|..|:||..|.:.||:|...  .|||.
 Frog   542 -----------------CRYGGTCV--APNK-----CLCPSGFTGSHCEKDIDECAEGIIECHNH 582

  Fly   891 GTCESGAGWFRCVCAQGF--------SGPDCRINVNECS--PQPCQGGATCIDGIGGYSCICPPG 945
            ..|.:..|||.|.|..||        ||..| ::::||:  ...|...:.|::..||:.|:||.|
 Frog   583 SRCVNLPGWFHCECRSGFHDNGTYSISGESC-VDIDECALRTHTCWNDSACVNLEGGFDCLCPSG 646

  Fly   946 --------------RHGL-------RCEIL-LSDPK-------SACQNASNTI------------ 969
                          |:|.       ||.:. ..|.|       ..|||.|..:
 Frog   647 PSCTGDCPHEGGLKRNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSVDLFCCPECDTRVTS 711

  Fly   970 -----SPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWCGLPNCYKVDPLSKSSN 1029
                 :.:...:...||           ..:|..|.|..|...|..|.|.:..| :...:|:
 Frog   712 QCLDQTGHKVYHSGDNW-----------TYSCQQCRCLEGEVDCWPLTCPILTC-EYTTISE--- 761

  Fly  1030 LSGVCKQHEVCVPALSETCLSSPCNVRGD 1058
              |.|..|          |:..||...||
 Frog   762 --GECCPH----------CVDDPCIADGD 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	9/47 (19%)
		DSL	220..282	CDD:279722	11/65 (17%)
		EGF_CA	350..388	CDD:238011	11/45 (24%)
		EGF_CA	490..526	CDD:238011	5/36 (14%)
		EGF_CA	610..645	CDD:238011	10/39 (26%)
		EGF_CA	647..683	CDD:238011	14/46 (30%)
		EGF_CA	798..833	CDD:238011	0/34 (0%)
		EGF_CA	879..913	CDD:238011	16/43 (37%)
		EGF_CA	916..952	CDD:238011	13/58 (22%)
		VWC_out	<993..1053	CDD:214565	13/59 (22%)
nell1	XP_031756556.1	TSPN	27..211	CDD:214560	41/240 (17%)
		VWC	354..408	CDD:327433	15/103 (15%)
		EGF_CA	453..>485	CDD:214542	12/31 (39%)
		EGF_3	499..534	CDD:403986	12/101 (12%)
		EGF_CA	568..605	CDD:214542	14/36 (39%)
		EGF_CA	615..653	CDD:214542	10/37 (27%)
		VWC	653..705	CDD:327433	10/51 (20%)
		VWC	720..768	CDD:327433	14/74 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000