Protein Alignment Ser and notch2

DIOPT Version :9

• Sequence 1: NP_001287558.1
• Gene: Ser / 43275
• FlyBaseID: FBgn0004197
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_001108566.2
• Gene: notch2 / 58065
• ZFINID: ZDB-GENE-000329-4
• Length: 2475
• Species: Danio rerio
• Alignment Length: 1116
• Identity: 315/1116 - (28%)
• Similarity: 443/1116 - (39%)
• Gaps: 267/1116 - (23%)

  Fly   103 GYCCGMP-AELRATKTIGCSP------CTTAFRLCLKEYQTTEQGASIST----GCSFGNATTKI 156
            |.|..:| .|...|    |:|      |......|:.......:|..::|    .|:.....|.:
Zfish   158 GICNALPNREYSCT----CAPGFHGSRCLNDTDECVDPLVCKNKGVCVNTIGSYRCNCQPGFTGL 218

  Fly   157 LGGSSFVLSDPGVGAIVLPF----TFRWTKSFTLILQALDMYNTSYPDAERLIEETSYSGVILPS 217
            ..||.:....|.      |.    |.|.|...|.:...|..:|.:  :.|..|::..
Zfish   219 DCGSPYFPCSPS------PCQNGGTCRQTTETTYVCHCLPGFNGT--NCEVNIDDCP-------- 267

  Fly   218 PEWKTLDHIGRNARI------TYRVRVQCAVTYYNTTCT---TFCR--PRDDQFG--------HY 263
                  ||..:|...      ||  ..||...:....||   ..||  |...|.|        .|
Zfish   268 ------DHRCQNGATCMDGVNTY--NCQCPPEWTGQFCTDDVDECRLQPNACQNGGTCSNTRNGY 324

  Fly   264 ACGSEGQKLCLNGWQGVNCEEAI-------CKAGCDPVHGKCDRPGE--CECRPGWRGPLC---- 315
            .|      :|:|||.|::|.|.|       |.||...:    ||...  |.|.||..|.||
Zfish   325 NC------VCVNGWSGLDCSENIDDCAAEPCTAGSTCI----DRVASFVCSCPPGKTGLLCHIDD 379

  Fly   316 ----NECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFC--GTHEPCKHGGTCENTAPDKY 374
                |.|.:...|.....||. :.|.|.:.:.|..|.:|::.|  |.: ||:|||:|:|| ...:
Zfish   380 ACISNPCKMGAHCDTNPVNGK-FSCNCPSGYKGSTCAEDIDECVIGPN-PCEHGGSCKNT-EGSF 441

  Fly   375 RCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRS 439
            .|.||.|.:|.:||...:.|.:.||:|..||..:..:.|                    ...|..
Zfish   442 TCNCAPGYTGPRCEQDINECGSNPCQNDATCLDQIGDYT--------------------CICMPG 486

  Fly   440 LDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGT 504
            .|....|.......|||   .|.:.:...|:: .|.|:|..|:||.||:::|||||..||.:|..
Zfish   487 FDGTHCENDINECLSSP---CLNNGRCLDQVS-RFVCECPQGFTGETCQVDIDECASTPCHNGAK 547

  Fly   505 CIDLIGGFRCECPPEWHGDVCQVDVNECE-APHSAGIAANALLTTTATAIIGSNLSSTALLAALT 568
            |:|...|:.|||...:.|.:|..::|:|| .|...|...:.:.|.....:.|           ..
Zfish   548 CLDRPNGYECECAEGFTGPLCMENINDCEPQPCHHGKCIDGIATFHCDCLPG-----------YM 601

  Fly   569 SAVASTSL---AIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQ-CRNGATCIDLVN 629
            ..:.|..:   ...||.|...|.:....:.|.|:.|..|..|..|.|||... |::| ||.|.:|
Zfish   602 GPICSEQIRECQSDPCQNGGRCVDMVNRYQCNCQPGTAGENCQINYDDCASNPCQHG-TCEDGIN 665

  Fly   630 DYRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPC 694
            :|:|.|..|:.|..|..:|:||:::||::||.|.|.|..|.|.||:|..|.||....:.|...||
Zfish   666 EYKCVCEPGYTGERCADEINECSSNPCQSGGTCEDKVNGFKCKCPVGTYGPLCLSGADRCIRMPC 730

  Fly   695 LEGHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEG----------------------CFA 737
            ..|.|:...|||.|.|.|...|.:|:|.:..|...||..|                      |..
Zfish   731 RHGECIGKQEGYLCQCEPGWEGTNCDQEKNECLSNPCQNGGTCNDRLNDYTCVCARGFAGFNCEI 795

  Fly   738 NVSLATSATTTTTTT----------------TTATTTRKMAKPSGLPCSGHGSCEMS-DVGTF-C 784
            |::...|.......|                |......|:...:..||...|.|:.| |..:: |
Zfish   796 NINECESNPCMNQGTCVDGVNSYVCHCKPPYTGKHCLEKLIPCASQPCQRRGVCQPSLDYTSYTC 860

  Fly   785 KCH--------------------------------------VGHTGTFCEHNLNECSPNPCRNGG 811
            |||                                      .|::|..|:.|:::||.|||||||
Zfish   861 KCHSGWEGAQCTEDKDECKKSPCQNGARCVNIVGSYRCECPPGYSGDNCQTNIDDCSSNPCRNGG 925

  Fly   812 ICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGLFCA 876
            .|:|..|.:.|||.:|:.|:||.|....|.:..|.|||.|    .|......|:|.||:.|:.|.
Zfish   926 TCVDKVGRYLCECRAGFYGERCEEEVDECASNPCWNGGHC----TDYVNSYTCQCPPGYDGINCE 986

  Fly   877 EAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCI 941
            ..|..|....|.|.|||..|...|.|.|.|||||..|:..:|||...||:.|.|||||:|.:.|.
Zfish   987 RDIPDCTETSCLNNGTCVDGINHFSCRCRQGFSGQYCQFELNECDSHPCKNGGTCIDGLGTFHCN 1051

  Fly   942 CPPGRHGLRCEILLS-DPKSACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGT 1005
            ||...:|..||.::: ..:..|||..      |.:.:..||                .|.|:.|
Zfish  1052 CPLMYNGKTCESMVNLCSQIKCQNGG------TCIQKEINW----------------RCSCQPG- 1093

  Fly  1006 SRCTNLWCGLP--NCYKVDPLSKSSNLSGVCKQ----------HE----------VCVPALSETC 1048
              .|.|:|.:|  :|:.| .|:|....:.|||.          |:          .|...:.| |
Zfish  1094 --WTGLYCDIPSMSCHAV-ALNKGVAENMVCKHAGHCKNIGNTHQCECQKGYTGSYCETEIDE-C 1154

  Fly  1049 LSSPCNVRGDC 1059
            |||||...|.|
Zfish  1155 LSSPCRNGGTC 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	14/68 (21%)
		DSL	220..282	CDD:279722	21/80 (26%)
		EGF_CA	350..388	CDD:238011	16/39 (41%)
		EGF_CA	490..526	CDD:238011	15/35 (43%)
		EGF_CA	610..645	CDD:238011	15/35 (43%)
		EGF_CA	647..683	CDD:238011	17/35 (49%)
		EGF_CA	798..833	CDD:238011	18/34 (53%)
		EGF_CA	879..913	CDD:238011	16/33 (48%)
		EGF_CA	916..952	CDD:238011	16/35 (46%)
		VWC_out	<993..1053	CDD:214565	21/81 (26%)
notch2	NP_001108566.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810