DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and SCUBE2

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001354906.1	Gene:	SCUBE2 / 57758	HGNCID:	30425	Length:	1028	Species:	Homo sapiens

Alignment Length:	959	Identity:	204/959 - (21%)
Similarity:	317/959 - (33%)	Gaps:	333/959 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   587 CRNQPGSFACICKEGWGGV--TCAENLDDCVGQCRNGAT--CIDLVNDYRCACASGF----KGRD 643
            |:|.|.|:.|.||.|:.|.  .| |::|:|..:...|..  |:::..:|||.|..||    .|.:
Human    62 CQNTPTSYKCSCKPGYQGEGRQC-EDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHN 125

  Fly   644 CETDIDECATSPCRNGG---ECVDMVGKFNCICPLGY-------------------------SGS 680
            | .|:|||..:   |||   .||:::|.:.|.|..|:                         ...
Human   126 C-LDVDECLEN---NGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSH 186

  Fly   681 LCEEAKE-----NCTPS------------PCLEGH------CLNTPEGYYCHCPPD----RAGKH 718
            :|:||..     .|.|.            .|..|:      |.:|.:|..|.|.|.    ..|:.
Human   187 ICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRS 251

  Fly   719 CEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCS-GHGSCEM----S 778
            |.:...             .|...|.:.||:.........|::...:   |: .:|.|:.    :
Human   252 CLERED-------------TVLEVTESNTTSVVDGDKRVKRRLLMET---CAVNNGGCDRTCKDT 300

  Fly   779 DVGTFCKCHVGHT----GTFCEHNLNECSPNPCRNGG---ICLDGDGDFTCECMSGWTGKRCSER 836
            ..|..|.|.||.|    |..|: :::||.   .||||   .|.:..|.|.|.|..|:
Human   301 STGVHCSCPVGFTLQLDGKTCK-DIDECQ---TRNGGCDHFCKNIVGSFDCGCKKGF-------- 353

  Fly   837 ATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCR-GQPCHNGGTCESGAGWF 900
                                 |.|.....|          :.:|:|. .:.|.:  :|.:..|.|
Human   354 ---------------------KLLTDEKSC----------QDVDECSLDRTCDH--SCINHPGTF 385

  Fly   901 RCVCAQGFS---GPDCRINVNECSPQPCQGGA--TCIDGIGGYSCICPPGRHGLRCEILLSDPKS 960
            .|.|.:|::   ...|. :.||||..  .||.  .|::.:|.|.|.|.||       ..|...|.
Human   386 ACACNRGYTLYGFTHCG-DTNECSIN--NGGCQQVCVNTVGSYECQCHPG-------YKLHWNKK 440

  Fly   961 ACQNAS----NTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWCGLPNCYKV 1021
            .|....    .::||..:|:          .|::...:.| ...|.:|    .:|..||...|.|
Human   441 DCVEVKGLLPTSVSPRVSLH----------CGKSGGGDGC-FLRCHSG----IHLSSGLQGAYSV 490

  Fly  1022 -----DPLSKSSNLSGVCKQHEVCVPALSET--CLSSPCNVRGDCRALEPSRRVAPPRLPAK-SS 1078
                 .||......|......:|.....|.|  .....|:::......|..|    |.||.| ||
Human   491 TCGSSSPLRNKQQKSNDSAFGDVTTIRTSVTFKLNEGKCSLKNAELFPEGLR----PALPEKHSS 551

  Fly  1079 CWPNQAVVNENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGMLMVLCD 1143
            ...:...||..|:            .|..|.|...            :|::     |..:.:..:
Human   552 VKESFRYVNLTCS------------SGKQVPGAPG------------RPST-----PKEMFITVE 587

  Fly  1144 LKTGTNDTVELTVSSS-----KLNDPQLPVAVGLLGELL---SFR-QLNGIQRRKELELQHAKLA 1199
            .:..||.. |:|.|..     |..:.:|..|:..|.:.:   .|. ||:|      :.|..||..
Human   588 FELETNQK-EVTASCDLSCIVKRTEKRLRKAIRTLRKAVHREQFHLQLSG------MNLDVAKKP 645

  Fly  1200 ALTSIVEVKLETARVADGSGHSLLIGVLCGVFIVLVGFSVFISLYWKQRLAYRTSSGMNLTPSLD 1264
            ..||  |.:.|:..|..|...:..:....|.:                               .|
Human   646 PRTS--ERQAESCGVGQGHAENQCVSCRAGTY-------------------------------YD 677

  Fly  1265 ALRHEEEK-----SNNLQNEE-NLRRYTNPLKGSTSSLRAATGMELS----LNPAPELAASAASS 1319
            ..|   |:     :...|||| .:.....|..|::.:|:......:|    |....|.:|..
Human   678 GAR---ERCILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADG--- 736

  Fly  1320 SALHRSQPLFPPCD------FERELDSST------GLKQAHKRSSQILLHKTQNSDMR------- 1365
                     |.||.      |:.|...::      ||...|:.::..     |:.:.|
Human   737 ---------FAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSF-----QDCETRVQCSPGH 787

  Fly  1366 -KNT---------VGSLDSPRKDFGKRSINCKSMPPSSGDEGSDVLATT 1404
             .||         ||:.   :.:|||.  ||.|.|   |:..:|...:|
Human   788 FYNTTTHRCIRCPVGTY---QPEFGKN--NCVSCP---GNTTTDFDGST 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011
		EGF_CA	490..526	CDD:238011
		EGF_CA	610..645	CDD:238011	11/40 (28%)
		EGF_CA	647..683	CDD:238011	13/63 (21%)
		EGF_CA	798..833	CDD:238011	12/37 (32%)
		EGF_CA	879..913	CDD:238011	9/37 (24%)
		EGF_CA	916..952	CDD:238011	13/37 (35%)
		VWC_out	<993..1053	CDD:214565	14/66 (21%)
SCUBE2	NP_001354906.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910