DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and megf6

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001073658.1	Gene:	megf6 / 567225	ZFINID:	ZDB-GENE-070112-1202	Length:	1339	Species:	Danio rerio

Alignment Length:	1272	Identity:	295/1272 - (23%)
Similarity:	416/1272 - (32%)	Gaps:	505/1272 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 ALDMYNTSYPDAERLIEETSYS--GVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCTT- 251
            :||:    .||...:.||...|  ||..|..:           ..|..|:|      :...|::
Zfish     6 SLDL----QPDMPNVCEEQEMSMLGVKQPCVQ-----------AFTRLVKV------WRQGCSSQ 49

  Fly   252 -FCRPRDDQFGHYACGSEGQKL-------CLNGW----QGVNCEEAICKAGCDPVHGKCDRPGE- 303
             :|...:.:.|:|....:...:       |..||    :...|...:|.:|.....|||....:
Zfish    50 RWCVGYERRTGYYTVYKQVYNMEMQTVFRCCPGWMQRGEERGCLHRVCSSGTCFNGGKCSETSDH 114

  Fly   304 -CECRPGWRGPLC----NECMVYPGCKHGSCNGS--AWKCVCDTNWGGILCDQDLNFCGTHEPCK 361
             |:|..|:.|..|    |||.|..|...|:|..|  ::.|.|.   ||.....|...|...:.|:
Zfish   115 LCQCPDGFEGTRCQYDINECAVSNGGCEGTCCNSIGSYFCKCP---GGSKLRDDGKSCQDIDECE 176

  Fly   362 --HGG---TCENTAPDKYRCTCAEGL----SGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQV 417
              :||   ||.||. ..|.|.|:||.    ....| |..:.|:.   :||| |..|..:....|
Zfish   177 EMNGGCQQTCVNTL-GSYHCECSEGFRIHADARTC-IAVNSCSV---KNGG-CEHKCVDLGNEQ- 234

  Fly   418 YRTSHGRSNMGRPVRRSSSMRSL-----DHLRPEGQALNGSSSP------GLVSLGSLQLQQQLA 471
            |: ...|||.  .::|......|     ||        ||..|.      |||.
Zfish   235 YK-CECRSNY--QLKRDGKHCELKDPCKDH--------NGGCSQICTDVNGLVQ----------- 277

  Fly   472 PDFTCDCAAGWTGPT----CEINIDECAGG--PCEHGGTCIDLIGGFRCECPPEWH----GDVC- 525
                |.|..|:|...    || :||||..|  .|.||  |:::.|.|||.|.|.:.    |..|
Zfish   278 ----CSCRTGFTLANDLRRCE-DIDECVSGQTKCAHG--CVNIPGSFRCVCNPGFELGADGKQCY 335

  Fly   526 QVD---VNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKEC 587
            :::   ||.||  .:.|..::....||:..:...| ....|...|.:.:.:.....|....:..|
Zfish   336 RIEMEIVNGCE--KNNGGCSHRCEHTTSGPLCSCN-QGYQLAEDLKTCIDTDECENGEACCSHFC 397

  Fly   588 RNQPGSFACICKEGW--GGVTCAENLDDCVGQCRNGAT--CIDLVNDYRCACASGFK-------- 640
            :|.||.:.|.|:.|:  .|.|| :::|:||.: .:|.:  |::.:..|.|.|..||:
Zfish   398 KNYPGGYECGCRPGYTPNGCTC-DDIDECVSE-TSGCSQYCVNSLGSYECFCQVGFRLDYDQKSC 460

  Fly   641 ------------------GRD-------------------------------------------- 643
                              |.:
Zfish   461 SPLYQREVEQEEEDEDLFGSEVEPEVLHLPNLLFRRPPQLLHYTAALHRPYDDDTHSYYPEDTHD 525

  Fly   644 --------------CETDI--DECATS--PCRNGGECVDMVGKFNCICPLGYSGSLCEE------ 684
                          |||.:  |:|:.|  .|.|||.|.  ..|..|:||.|::|.:|.:
Zfish   526 PEHREELTTISKSMCETGVFGDDCSVSCEDCVNGGVCA--AEKDRCVCPPGWTGLICNDTCPEGT 588

  Fly   685 --AKEN----------CTP-------SPCLEG-HCLN-TPEGYY-------CHCPPDRAGKHCEQ 721
              |:.|          |.|       .|.:.| ||.| .|:|:|       |:||.:   .||.:
Zfish   589 YGAECNSLCVCKNGGRCDPVTGKCLCPPGVHGLHCENGCPQGFYGRLCRRRCNCPNN---GHCHR 650

  Fly   722 LRPLCSQPP-------------------CNEGCFANVSLATSATTTTTTTTTATTTRKMAKPS-- 765
            |...|...|                   |:|.|......:.|......|.        :.||.
Zfish   651 LYGGCLCTPGLYGKFCHLPCPKWSHGAGCSEECECVQENSLSCDPQMGTC--------LCKPGYH 707

  Fly   766 -------------GLPCSG-------------------------HG------------------- 773
                         |:.|.|                         ||
Zfish   708 GDRCQTDCDDGYFGVGCHGLCNCSDGKSCDPKTGECQRMCPAGYHGEKCQMVCEAGFWGAGCANV 772

  Fly   774 --------SCEMSDVGTFCKCHVGHTGTFCEHNLNE----------CSPNPCRNGGICLDGDGDF 820
                    |||.|. |. |.|..|:||..|:...:|          |.   |.||..|....|
Zfish   773 CQCASNAVSCESSS-GR-CVCESGYTGQHCDKKCSEGLYGADCKQVCE---CENGAECDHVSG-- 830

  Fly   821 TCECMSGWTGKRCSERATGCYAG-------QCQNGGTC--MPGAPDKALQPHCRCAPGWT----- 871
            .|.|.:||.|..|.:|....:.|       ||:|...|  :.||        |||.|||.
Zfish   831 ACTCAAGWVGSHCEKRCPVGFYGQDCAQMCQCRNEAQCHHITGA--------CRCTPGWAPPHCI 887

  Fly   872 --------GLFCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECS------- 921
                    ||.|:::.|      |||||:|:..:|  :|.||.|::|..|:   ..|:
Zfish   888 LACPAGTFGLNCSQSCD------CHNGGSCDPVSG--QCSCAPGWTGDRCQ---QTCASGWFGKN 941

  Fly   922 -PQPC-----------QGGATCIDGIGGYSC--ICPPGRHGLRCEILLS-----------DPKSA 961
             .|.|           .|...|..|..|.||  :||.||.||.|..:.|           ..:.:
Zfish   942 CEQKCICPVGVACDHVTGRCGCPAGYTGNSCEKMCPQGRFGLNCSRVCSCSGDQYRCHHITGRCS 1006

  Fly   962 CQNASN-----------TISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWCGL 1015
            ||...|           |..||.....|     .|..||.  |....:|:|:.|       :.|
Zfish  1007 CQPGYNGNRCLLRCREGTYGPYCKKRCS-----CANGGRC--DFRNGSCICQPG-------YFG- 1056

  Fly  1016 PNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSCW 1080
            |||....|   |.:....|.|  ||           .|..:|.|.             |....|
Zfish  1057 PNCSISCP---SGHYGRDCAQ--VC-----------SCGEKGQCH-------------PETGRC- 1091

  Fly  1081 PNQAVVNENCARLTILLALERV---GK-GASVEGLCS 1113
                    |||..|..|:.|::   |: |......|:
Zfish  1092 --------NCAPGTTGLSCEQMCPRGRYGVQCRSFCT 1120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722	10/74 (14%)
		EGF_CA	350..388	CDD:238011	14/46 (30%)
		EGF_CA	490..526	CDD:238011	17/42 (40%)
		EGF_CA	610..645	CDD:238011	11/120 (9%)
		EGF_CA	647..683	CDD:238011	14/39 (36%)
		EGF_CA	798..833	CDD:238011	12/44 (27%)
		EGF_CA	879..913	CDD:238011	13/33 (39%)
		EGF_CA	916..952	CDD:238011	15/56 (27%)
		VWC_out	<993..1053	CDD:214565	14/59 (24%)
megf6	NP_001073658.1	EMI	15..83	CDD:284877	14/84 (17%)
		FXa_inhibition	134..169	CDD:291342	11/37 (30%)
		vWFA	<159..209	CDD:294047	15/50 (30%)
		FXa_inhibition	258..293	CDD:291342	12/57 (21%)
		vWFA	<293..332	CDD:294047	17/41 (41%)
		FXa_inhibition	345..380	CDD:291342	8/37 (22%)
		vWFA	<372..413	CDD:294047	10/40 (25%)
		vWFA	<419..459	CDD:294047	11/41 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910