DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and fat1b

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_021328497.1	Gene:	fat1b / 565591	ZFINID:	ZDB-GENE-130530-563	Length:	4503	Species:	Danio rerio

Alignment Length:	790	Identity:	183/790 - (23%)
Similarity:	258/790 - (32%)	Gaps:	208/790 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 RPCRNGGTCTLKTSNRTQAQVYRTSHG--RSNMGRPVRRSSSMRSLDHLRPEG---------QAL 450
            ||.|..|..      ...:|...:|.|  :...|..|.|..:.|.|....|:|         |..
Zfish  3718 RPRRGAGAL------EALSQKISSSRGAIKEMTGLHVVRVLNSRCLSSECPDGKCRRVLLFNQTT 3776

  Fly   451 NGSSSPGLVSLGSLQLQQQLAP--DFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFR 513
            .|:.|...||        .:.|  ..|..|..  |...|......|....|..|..|:...|..:
Zfish  3777 MGAYSTARVS--------YITPRHHMTAKCLC--TDSKCLKQEYTCVNSTCPEGYECVSGFGQDK 3831

  Fly   514 CECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNL--SSTALLAALTSAVASTS- 575
            ..|              .|........:..:.:|.:.::.|..:|  |...|...|.....||.
Zfish  3832 HSC--------------ICTGAAKVKCSGGSSMTFSESSYIKYSLMESMKGLKLTLKLKTLSTEG 3882

  Fly   576 ---LAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGATCIDLVNDYRCACAS 637
               ||.|...:..|.......|...|  |||..|.:.:              ..||||.:...|.
Zfish  3883 TIMLARGTGHSILEIAGGRLQFQFDC--GWGFATVSVH--------------SVLVNDGQWHMAE 3931

  Fly   638 -GFKGRDCETDIDE------CATSP--CRNGGECVDMVGKFNCICPLGYSGSLCEEAKEN----- 688
             ..||......:|:      .|..|  |.|.||.| ::|        |::..|....:.|
Zfish  3932 LEVKGNYARLVLDQLHSASGIAPGPLHCLNLGEQV-VLG--------GHAQHLGSRRRRNLPASN 3987

  Fly   689 ----CTPSPCLEGHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTT 749
                |..|..|.||.|:.          |..|.....:..:....|   |||...|...|:.
Zfish  3988 SLQGCMDSVLLNGHRLSL----------DSGGPLGVTIEDMVGVSP---GCFGFTSPVCSSN--- 4036

  Fly   750 TTTTTATTTRKMAKPSGLPCSGHGSCEM-SDVGTFCKCHVGHTGTFCEHNLNECSPNPCRNGGIC 813
                              ||...|||.| ...|..|||....:||.||..::.|..|||..||.|
Zfish  4037 ------------------PCLNGGSCLMRQSGGNICKCSPSFSGTRCEVKISPCDSNPCLYGGTC 4083

  Fly   814 LDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGLFCAEA 878
            :..:.|::|:|...::|:|| :....|....|||||.|:... |.|:   |.|.||:.|..|...
Zfish  4084 IQNNLDYSCKCRGKYSGQRC-QIGPYCKENPCQNGGQCIDSL-DGAI---CECEPGFKGERCMID 4143

  Fly   879 IDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICP 943
            :|:|..:||.|.|.|.:..|.|.|.|..||||..|.|. .|.|.||.  .::....||....|..
Zfish  4144 VDECVDRPCFNDGHCVNTRGSFTCSCMIGFSGRLCEIG-TEVSNQPI--SSSWNSWIGELVAILA 4205

  Fly   944 ----------------PGRHGLRCEILLSDPK-SACQNASNTISPYTALNRSQNWLDIALTGRTE 991
                            .|    .|:.:..|.. ...::..:.|...:..|..:|        ::.
Zfish  4206 FLAVIFVVTLLFLIVWKG----SCKRIKRDKDLDKVKDIDSYIQRLSFYNHGKN--------KSR 4258

  Fly   992 DDENCNACVCENGTSRCTNLWCGLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVR 1056
            .|                     .|....|.|:|.:.::.|.|:.:...||..|.........:|
Zfish  4259 SD---------------------TPPLVPVRPISYTPSIPGECRNNRGSVPEFSNFTADPLFGLR 4302

  Fly  1057 GDCRALEPSRRVAP--PRLPAKSSCWPNQAV--------VNENCARLTILLALE-------RVGK 1104
            .......    |||  |...|..|...|.::        .:|....||..||:|       |..:
Zfish  4303 KSVAVCS----VAPNLPHRKASYSHSENDSIQQMDWDEEYDEKILDLTSCLAMEDDYISLSRDNR 4363

  Fly  1105 GASVEGLCSL 1114
            |  ::..|||
Zfish  4364 G--LQSTCSL 4371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011
		EGF_CA	490..526	CDD:238011	6/35 (17%)
		EGF_CA	610..645	CDD:238011	7/35 (20%)
		EGF_CA	647..683	CDD:238011	11/43 (26%)
		EGF_CA	798..833	CDD:238011	11/34 (32%)
		EGF_CA	879..913	CDD:238011	15/33 (45%)
		EGF_CA	916..952	CDD:238011	8/51 (16%)
		VWC_out	<993..1053	CDD:214565	10/59 (17%)
fat1b	XP_021328497.1	Cadherin_repeat	45..150	CDD:206637
		Cadherin_repeat	159..259	CDD:206637
		E_set	272..359	CDD:324323
		Cadherin_repeat	377..467	CDD:206637
		Cadherin_repeat	476..573	CDD:206637
		Cadherin_repeat	584..673	CDD:206637
		Cadherin_repeat	729..826	CDD:206637
		Cadherin_repeat	834..931	CDD:206637
		Cadherin_repeat	939..1036	CDD:206637
		Cadherin_repeat	1050..1143	CDD:206637
		Cadherin_repeat	1151..1249	CDD:206637
		Cadherin_repeat	1273..1347	CDD:206637
		Cadherin_repeat	1365..1477	CDD:206637
		Cadherin_repeat	1485..1583	CDD:206637
		Cadherin_repeat	1591..1687	CDD:206637
		Cadherin_repeat	1696..1786	CDD:206637
		Cadherin_repeat	1794..1899	CDD:206637
		Cadherin_repeat	1908..1996	CDD:206637
		Cadherin_repeat	2008..2102	CDD:206637
		Cadherin_repeat	2110..2199	CDD:206637
		Cadherin_repeat	2211..2303	CDD:206637
		Cadherin_repeat	2311..2410	CDD:206637
		Cadherin_repeat	2419..2512	CDD:206637
		Cadherin_repeat	2520..2616	CDD:206637
		Cadherin_repeat	2624..2714	CDD:206637
		Cadherin_repeat	2730..2825	CDD:206637
		Cadherin_repeat	2838..>2915	CDD:206637
		Cadherin_repeat	2943..3041	CDD:206637
		Cadherin_repeat	3054..3143	CDD:206637
		Cadherin_repeat	3153..3248	CDD:206637
		Cadherin_repeat	3256..3353	CDD:206637
		Cadherin_repeat	3361..3458	CDD:206637
		Cadherin_repeat	3467..3553	CDD:206637
		Cadherin_repeat	3567..3652	CDD:206637
		Laminin_G_2	3881..4001	CDD:308045	32/144 (22%)
		EGF	4033..4064	CDD:306513	12/51 (24%)
		EGF_CA	4069..4104	CDD:238011	13/35 (37%)
		EGF	4109..4139	CDD:306513	14/33 (42%)
		EGF_CA	4143..4179	CDD:238011	15/35 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910