DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ser and TENM3

DIOPT Version :9

Sequence 1:NP_001287558.1 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster
Sequence 2:XP_016863874.1 Gene:TENM3 / 55714 HGNCID:29944 Length:2715 Species:Homo sapiens


Alignment Length:555 Identity:130/555 - (23%)
Similarity:189/555 - (34%) Gaps:210/555 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   579 GPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGATCIDLVNDYRCACASGFKGRD 643
            |.|::. .|...||.....|......|.|:.|     ||...|          ||.|.||:||.:
Human   526 GECVSG-TCHCFPGFLGPDCSRAACPVLCSGN-----GQYSKG----------RCLCFSGWKGTE 574

  Fly   644 CETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCL-EGHCLNTPEGYY 707
            |:....:|....|...|.|:  :|  :|.|..||.|..||||  :|....|. .|.|::..    
Human   575 CDVPTTQCIDPQCGGRGICI--MG--SCACNSGYKGESCEEA--DCIDPGCSNHGVCIHGE---- 629

  Fly   708 CHCPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGH 772
            |||.|...|.:||.|:.:|..                                       .||||
Human   630 CHCSPGWGGSNCEILKTMCPD---------------------------------------QCSGH 655

  Fly   773 GSCEMSDVGTFCKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERA 837
            |: .:.:.|: |.|....||..|.:.:  ||.: |.:.|:|:.|    ||.|..||||..|::||
Human   656 GT-YLQESGS-CTCDPNWTGPDCSNEI--CSVD-CGSHGVCMGG----TCRCEEGWTGPACNQRA 711

  Fly   838 TGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCESGAGWFRC 902
                         |           |.|||                     ..|||:.|    :|
Human   712 -------------C-----------HPRCA---------------------EHGTCKDG----KC 727

  Fly   903 VCAQGFSGPDCRIN------VNECSPQPCQGGATCIDGIGGYSCICPPGRHGLRCEILLSDPKSA 961
            .|:||::|..|.|.      |.|..|..|.....|.....|:.|:|.||..|..|::.:   ::.
Human   728 ECSQGWNGEHCTIAHYLDKIVKEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAM---ETL 789

  Fly   962 CQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWCGLPNCYKVDPLSK 1026
            |.::.:                      .|.|                    ||.:|  :||   
Human   790 CTDSKD----------------------NEGD--------------------GLIDC--MDP--- 807

  Fly  1027 SSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSCWPNQAVVNENCA 1091
                               :.||.|.|..:..||.|..     |..:.::|...|:|........
Human   808 -------------------DCCLQSSCQNQPYCRGLPD-----PQDIISQSLQSPSQQAAKSFYD 848

  Fly  1092 RLTILLALERV----GKGASVEGLCSLVR--VLLA 1120
            |::.|:..:..    |:....:.|.|::|  ||.|
Human   849 RISFLIGSDSTHVIPGESPFNKSLASVIRGQVLTA 883

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SerNP_001287558.1 MNNL 83..161 CDD:284966
DSL 220..282 CDD:279722
EGF_CA 350..388 CDD:238011
EGF_CA 490..526 CDD:238011
EGF_CA 610..645 CDD:238011 11/34 (32%)
EGF_CA 647..683 CDD:238011 10/35 (29%)
EGF_CA 798..833 CDD:238011 13/34 (38%)
EGF_CA 879..913 CDD:238011 9/33 (27%)
EGF_CA 916..952 CDD:238011 11/41 (27%)
VWC_out <993..1053 CDD:214565 9/59 (15%)
TENM3XP_016863874.1 Ten_N 11..308 CDD:284015
EGF_2 <522..544 CDD:285248 5/18 (28%)
Keratin_B2 579..731 CDD:279797 65/258 (25%)
EGF_2 583..609 CDD:285248 9/29 (31%)
EGF_2 614..641 CDD:285248 9/30 (30%)
EGF_2 649..676 CDD:285248 10/67 (15%)
DSL <666..707 CDD:302925 17/47 (36%)
DSL <697..738 CDD:302925 22/89 (25%)
EGF_CA 753..782 CDD:238011 9/28 (32%)
NHL 1155..1514 CDD:302697
NHL repeat 1184..1223 CDD:271320
NHL repeat 1235..1278 CDD:271320
NHL repeat 1302..1336 CDD:271320
NHL repeat 1358..1397 CDD:271320
NHL repeat 1420..1453 CDD:271320
NHL 1483..>1609 CDD:302697
NHL repeat 1488..1514 CDD:271320
NHL repeat 1490..1517 CDD:271320
NHL repeat 1564..1607 CDD:271320
RhsA 1629..2430 CDD:225750
YD_repeat_2x 1839..1879 CDD:273728
Rhs_assc_core 2334..2408 CDD:274730
Tox-GHH 2633..2708 CDD:292269
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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