DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and NOTCH3

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_000426.2	Gene:	NOTCH3 / 4854	HGNCID:	7883	Length:	2321	Species:	Homo sapiens

Alignment Length:	1110	Identity:	304/1110 - (27%)
Similarity:	415/1110 - (37%)	Gaps:	365/1110 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 EGQKLCLNGWQGVNCEEAICKAGCDPVH-GKCDRPG-------------ECECRPGWRGPLC--- 315
            |...||..||.|..|:..      ||.| |.|...|             .|.|..|:|||.|
Human    62 EAACLCPPGWVGERCQLE------DPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP 120

  Fly   316 NECMVYPGCKHGS-CN---GSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRC 376
            :.|:..| |.||: |:   ...:.|.|...:.|..|..|::.|...|||:|||||.|| |..:||
Human   121 DPCLSSP-CAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNT-PGSFRC 183

  Fly   377 TCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLD 441
            .|..|.:|..||....|||..||||||||                          |:|..:
Human   184 QCPAGYTGPLCENPAVPCAPSPCRNGGTC--------------------------RQSGDL---- 218

  Fly   442 HLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCI 506
                                           .:.|.|..|:.|..||:|:|:|.|..|.:||||:
Human   219 -------------------------------TYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCV 252

  Fly   507 DLIGGFRCECPPEWHGDVCQVDVNECE----APHSAGIAANAL-------------------LTT 548
            |.:..:.|:|||||.|..|..||:||:    |.|:.|...|.|                   :..
Human   253 DGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDD 317

  Fly   549 TATAII--GSN-------------LSSTALLAALTSAVAST------------------------ 574
            .|||:.  |:.             :..|.||..|..|..|.
Human   318 CATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPG 382

  Fly   575 -------------SLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCV-GQCRNGATCI 625
                         |:...||.:...|.|..|||.|.|..|:.|..|..::::|: |.|||.|||:
Human   383 FTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCL 447

  Fly   626 DLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCT 690
            |.:..:.|.|.:||.|..||.|||||.:|||.|||.|.|.|..|:|.||.|:|||.|:...:.|.
Human   448 DRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECA 512

  Fly   691 PSPCLEG-HCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEG-CFANVSLATSATTTTTTTT 753
            .:||..| .|::.|:||.|.|.....|..|::....||..||:.| |...::..:.|.....|.|
Human   513 STPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGT 577

  Fly   754 TATTTRKMAKPSGLPCSGHG---------------------SCEM------SDVGTF-------- 783
            ...:  ::.:....||. ||                     :||:      |:..||
Human   578 RCES--QVDECRSQPCR-HGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGIN 639

  Fly   784 ---CKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGD---------------------------- 817
               |.|..|.||..|...:|||:.:||..||.|:||:
Human   640 RYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPC 704

  Fly   818 ---------GDFTCECMSGWTGKRCSERAT--GCYAGQCQNGGTCM-----------PGAPDKAL 860
                     |.|.|.|..||:|.|||:...  .|.:..|:.||||.           ||...:..
Human   705 SHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQC 769

  Fly   861 Q-----------------------PHCRCAPGWTGLFCAEAIDQCRG-QPCHNGGTCESGAGWFR 901
            :                       |.|.|..||.|..|.:.:|:|.| .||...|.|.:.||.|.
Human   770 ELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFS 834

  Fly   902 CVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICPPGRHGLRCEILLSDPKSACQNAS 966
            |.|..|::||.|..::|:|.|.||..|.:|.||:|.:||.|.||..|.||      .:...:..|
Human   835 CTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRC------ARDVDECLS 893

  Fly   967 NTISPYTALNRSQNWLDIALTGR-----TEDDENCNACVCENGTSRCTNLWCGLPNCYKVDPLSK 1026
            |...|.|..:...::......|.     .:|..:|:...|.||.:           |  ||.::.
Human   894 NPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGT-----------C--VDGVNS 945

  Fly  1027 SSNL-----SGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSCWPNQAVV 1086
            .|.|     :|...|||      ::.|||.||...|.|.|..|..|           |...::..
Human   946 FSCLCRPGYTGAHCQHE------ADPCLSRPCLHGGVCSAAHPGFR-----------CTCLESFT 993

  Fly  1087 NENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKPASTFGQ----------DPGMLMVL 1141
            ...|..|.               ..||           ::|....|:          .||....|
Human   994 GPQCQTLV---------------DWCS-----------RQPCQNGGRCVQTGAYCLCPPGWSGRL 1032

  Fly  1142 CDLKT 1146
            ||:::
Human  1033 CDIRS 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722	6/13 (46%)
		EGF_CA	350..388	CDD:238011	18/37 (49%)
		EGF_CA	490..526	CDD:238011	17/35 (49%)
		EGF_CA	610..645	CDD:238011	14/35 (40%)
		EGF_CA	647..683	CDD:238011	22/35 (63%)
		EGF_CA	798..833	CDD:238011	17/71 (24%)
		EGF_CA	879..913	CDD:238011	15/34 (44%)
		EGF_CA	916..952	CDD:238011	17/35 (49%)
		VWC_out	<993..1053	CDD:214565	16/64 (25%)
NOTCH3	NP_000426.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		EGF_CA	158..195	CDD:238011	18/37 (49%)
		EGF_CA	236..272	CDD:238011	17/35 (49%)
		EGF_CA	274..311	CDD:238011	9/36 (25%)
		EGF_CA	314..349	CDD:238011	6/34 (18%)
		EGF_CA	391..429	CDD:238011	12/37 (32%)
		EGF_CA	431..467	CDD:238011	14/35 (40%)
		EGF_CA	469..505	CDD:238011	22/35 (63%)
		EGF_CA	507..542	CDD:238011	11/34 (32%)
		EGF_CA	545..580	CDD:238011	9/34 (26%)
		EGF_CA	583..618	CDD:238011	4/35 (11%)
		EGF_CA	620..654	CDD:238011	8/33 (24%)
		EGF_CA	657..>686	CDD:214542	10/28 (36%)
		EGF_CA	810..846	CDD:238011	15/35 (43%)
		EGF_CA	849..884	CDD:238011	16/34 (47%)
		EGF_CA	887..922	CDD:238011	5/34 (15%)
		EGF_CA	929..960	CDD:238011	9/43 (21%)
		EGF_CA	1085..1120	CDD:238011
		EGF_CA	1122..1158	CDD:238011
		EGF_CA	1171..1203	CDD:238011
		Notch	1384..1418	CDD:278494
		LNR 1	1387..1427
		Notch	1425..1459	CDD:278494
		LNR 2	1428..1458
		Notch	1464..1500	CDD:278494
		LNR 3	1467..1505
		NOD	1508..1557	CDD:284282
		NODP	1578..1637	CDD:284987
		ANKYR	<1777..1893	CDD:223738
		ANK	<1779..1892	CDD:238125
		ANK repeat	1788..1836	CDD:293786
		ANK repeat	1838..1869	CDD:293786
		ANK 1	1838..1867
		Ank_5	1858..1913	CDD:290568
		ANK	1866..1992	CDD:238125
		ANK repeat	1871..1903	CDD:293786
		ANK 2	1871..1901
		ANK repeat	1905..1936	CDD:293786
		ANK 3	1905..1934
		Ank_2	1910..2002	CDD:289560
		ANK repeat	1938..1969	CDD:293786
		ANK 4	1938..1967
		ANK repeat	1971..2002	CDD:293786
		ANK 5	1971..2000
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2024..2120
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2190..2321
		DUF3454	2212..2273	CDD:288764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I11059
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810