DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and NOTCH1

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_060087.3	Gene:	NOTCH1 / 4851	HGNCID:	7881	Length:	2555	Species:	Homo sapiens

Alignment Length:	1187	Identity:	326/1187 - (27%)
Similarity:	456/1187 - (38%)	Gaps:	341/1187 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 ASISTGCSFG-NATTKILGGSSFVLSDPGVGAIVLPFTFRWTKSFTLILQALDMYNTSYPDAERL 204
            |.||..|:.| |..|..:.|.:......|.                           :.|...:.
Human   375 ACISNPCNEGSNCDTNPVNGKAICTCPSGY---------------------------TGPACSQD 412

  Fly   205 IEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTC--------TTFCRPRD---- 257
            ::|.|...        ...:|.|:..........||...|....|        :..|: .|
Human   413 VDECSLGA--------NPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQ-NDATCL 468

  Fly   258 DQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPV--HGKC-DRPGE--CECRPGWRGPLC-- 315
            ||.|.:.|      :|:.|::||:||....:....|.  :|:| |:..|  |||..|:.|.||
Human   469 DQIGEFQC------ICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQY 527

  Fly   316 --NECMVYPGCKHGS-C--NGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYR 375
              :||...| ||:|: |  ..:.:.|||...:.|..|:.|::.|.. :|| |.|:|::... .:.
Human   528 DVDECASTP-CKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDP-DPC-HYGSCKDGVA-TFT 588

  Fly   376 CTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSL 440
            |.|..|.:|..||...:.|:::|||:||||    .:|..|.:.....|.:.....:       :|
Human   589 CLCRPGYTGHHCETNINECSSQPCRHGGTC----QDRDNAYLCFCLKGTTGPNCEI-------NL 642

  Fly   441 DHLRPEGQALNGSSSP--GLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGG 503
            |         :.:|||  ....|..:.       .:.|.|..|:||..|.||||||||.||.:||
Human   643 D---------DCASSPCDSGTCLDKID-------GYECACEPGYTGSMCNINIDECAGNPCHNGG 691

  Fly   504 TCIDLIGGFRCECPPEWHGDVCQVDVNECEA-PHSAGIAANALLTTTATAIIGSNLSSTALLAAL 567
            ||.|.|.||.|.||..:|...|..:||||.: |...|...::|        .|.........:..
Human   692 TCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSL--------NGYKCDCDPGWSGT 748

  Fly   568 TSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQ-CRNGATCIDLVNDY 631
            ...:.:......||:|...|::....:.|.|:||:.|..|..|:::|... |.|..||||.|..|
Human   749 NCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGY 813

  Fly   632 RCACASGFKGRDCETDIDECATSPCRNGGEC--VDMVGKFNCICPLGYSGSLCEEAKENCTPSPC 694
            :|.|...:.|..||..:..||.|||||||||  .:....|:|:||.|:.|..||.....|..|||
Human   814 KCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPC 878

  Fly   695 LEG-HCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATTT 758
            ..| .|.||..||.|||....:|::||.....|...||:.|
Human   879 RHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNG------------------------ 919

  Fly   759 RKMAKPSGLPCSGHGSCEMSDVGTFCKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCE 823
                          |||.......||.|..|..|||||.::|||:.:|||||..|.|....:||.
Human   920 --------------GSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCT 970

  Fly   824 CMSGWTGKRCSERATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQPCH 888
            |.:|::|..|......|....|.|||||:.|.....    |.|.||:||.:|...:::|..|||.
Human   971 CPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFT----CLCPPGFTGSYCQHDVNECDSQPCL 1031

  Fly   889 NGGTCESGAGWFRCVCAQGFSGPDCRIN------------------------------------- 916
            :||||:.|.|.:||.|.||::||:|: |
Human  1032 HGGTCQDGCGSYRCTCPQGYTGPNCQ-NLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCD 1095

  Fly   917 --------------------------------------------------VNECSPQPCQGGATC 931
                                                              |:||||.|||.||||
Human  1096 VPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATC 1160

  Fly   932 IDGIGGYSCICPPGRHGLRC--EI--LLSDPKSACQNASNTISPYTALNRSQNWLDIALTGRTED 992
            .|.:|||||.|..|.||:.|  ||  .||.|   |||.                      |...|
Human  1161 TDYLGGYSCKCVAGYHGVNCSEEIDECLSHP---CQNG----------------------GTCLD 1200

  Fly   993 DENCNACVCENGTSRCTNLWC--GLPNCY-KVDPLSKSSNL--SGVCKQH--------------E 1038
            ..|...|.|..||.   .:.|  .:.:|. .|||:|:|...  :|.|...              |
Human  1201 LPNTYKCSCPRGTQ---GVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGE 1262

  Fly  1039 VCVPALSETCLSSPCNVRG-------------DCRALEPSRRVAPPRLPAKSSCWPNQAVVNENC 1090
            .|...::| |||:||:.||             :|||....||           |   ::|:| .|
Human  1263 RCEGDVNE-CLSNPCDARGTQNCVQRVNDFHCECRAGHTGRR-----------C---ESVIN-GC 1311

  Fly  1091 ARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGMLMVLCDLKTGTNDTVELT 1155
            .           ||.....|.|::........:.|.||...|       ..|:....|..::...
Human  1312 K-----------GKPCKNGGTCAVASNTARGFICKCPAGFEG-------ATCENDARTCGSLRCL 1358

  Fly  1156 VSSSKLNDPQLPVAVGL 1172
            ...:.::.|:.|..:.|
Human  1359 NGGTCISGPRSPTCLCL 1375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	8/20 (40%)
		DSL	220..282	CDD:279722	16/73 (22%)
		EGF_CA	350..388	CDD:238011	11/37 (30%)
		EGF_CA	490..526	CDD:238011	21/35 (60%)
		EGF_CA	610..645	CDD:238011	13/35 (37%)
		EGF_CA	647..683	CDD:238011	17/37 (46%)
		EGF_CA	798..833	CDD:238011	15/34 (44%)
		EGF_CA	879..913	CDD:238011	17/33 (52%)
		EGF_CA	916..952	CDD:238011	24/124 (19%)
		VWC_out	<993..1053	CDD:214565	20/78 (26%)
NOTCH1	NP_060087.3	EGF_CA	142..175	CDD:238011
		EGF_CA	178..216	CDD:238011
		EGF_CA	223..255	CDD:238011
		EGF_CA	257..293	CDD:238011
		EGF_CA	295..332	CDD:238011
		EGF_CA	335..370	CDD:238011
		EGF_CA	412..450	CDD:238011	7/45 (16%)
		Interaction with DLL4. /evidence=ECO:0000250\|UniProtKB:Q07008	420..421		0/8 (0%)
		Interaction with DLL4. /evidence=ECO:0000250\|UniProtKB:Q07008	448..452		1/3 (33%)
		EGF_CA	452..488	CDD:238011	10/42 (24%)
		EGF_CA	490..526	CDD:238011	11/35 (31%)
		EGF_CA	528..564	CDD:238011	11/36 (31%)
		EGF_CA	566..601	CDD:238011	11/37 (30%)
		EGF_CA	603..639	CDD:238011	11/39 (28%)
		EGF_CA	678..713	CDD:238011	21/34 (62%)
		EGF_CA	717..750	CDD:238011	8/40 (20%)
		EGF_CA	755..789	CDD:238011	9/33 (27%)
		EGF_CA	791..827	CDD:238011	13/35 (37%)
		EGF_CA	869..905	CDD:238011	14/35 (40%)
		EGF_CA	907..943	CDD:238011	14/73 (19%)
		EGF_CA	945..981	CDD:238011	15/35 (43%)
		EGF_CA	988..1019	CDD:238011	13/34 (38%)
		EGF_CA	1021..1057	CDD:238011	17/35 (49%)
		EGF	1063..1093	CDD:278437	0/29 (0%)
		EGF_CA	1146..1180	CDD:238011	22/33 (67%)
		EGF_CA	1184..1219	CDD:238011	14/62 (23%)
		EGF_CA	<1238..1265	CDD:238011	3/26 (12%)
		EGF_CA	1267..1305	CDD:238011	14/52 (27%)
		NL	1442..1479	CDD:197463
		LNR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00525	1449..1489
		Notch	1487..1522	CDD:278494
		LNR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00525	1490..1531
		Notch	1525..1561	CDD:278494
		LNR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00525	1532..1571
		NOD	1567..1618	CDD:284282
		NODP	1672..1729	CDD:284987
		Interaction with PSEN1. /evidence=ECO:0000269\|PubMed:30598546	1728..1760
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1780..1808
		Ank_2	<1873..1958	CDD:289560
		ANK repeat	1880..1925	CDD:293786
		ANK	1922..2034	CDD:238125
		ANK repeat	1927..1958	CDD:293786
		ANK 1. /evidence=ECO:0000255	1927..1956
		Ank_2	1932..2025	CDD:289560
		HIF1AN-binding. /evidence=ECO:0000250	1947..1955
		ANK repeat	1960..1991	CDD:293786
		ANK 2. /evidence=ECO:0000255	1960..1990
		ANK	1989..2113	CDD:238125
		ANK repeat	1994..2025	CDD:293786
		ANK 3. /evidence=ECO:0000255	1994..2023
		Ank_2	1999..2091	CDD:289560
		HIF1AN-binding. /evidence=ECO:0000250	2014..2022
		ANK repeat	2027..2058	CDD:293786
		ANK 4. /evidence=ECO:0000255	2027..2056
		ANK repeat	2060..2091	CDD:293786
		ANK 5. /evidence=ECO:0000255	2060..2089
		ANK 6	2095..2122
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2151..2194
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2379..2447
		Med25_SD1	<2429..2514	CDD:288132
		DUF3454	2479..2540	CDD:288764
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2483..2555
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I12003
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910