Protein Alignment Ser and Delta

DIOPT Version :10

• Sequence 1: NP_524527.3
• Gene: Ser / 43275
• FlyBaseID: FBgn0004197
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_477264.1
• Gene: Delta / 42313
• FlyBaseID: FBgn0000463
• Length: 833
• Species: Drosophila melanogaster
• Alignment Length: 1001
• Identity: 290/1001 - (28%)
• Similarity: 404/1001 - (40%)
• Gaps: 223/1001 - (22%)

  Fly    66 CNLIALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGCSPCTTAFRLC 130
            |.|.|.|...::.::.::|:|||.:...||.:.....|.||...::....|.:|  .|.|.||:|
  Fly     6 CLLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLG--SCKTRFRVC 68

  Fly   131 LKEYQTTEQGASISTGCSFGNATTKILGGSSFVLSDPG-------VGAIVLPFTFRWTKSFTLIL 188
            ||.||.|   ...::.|::|:..|.|||.:|..|:|..       ...|..||:|.|..:|:||:
  Fly    69 LKHYQAT---IDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIV 130

  Fly   189 QAL-DMYNTSYPDAER-LIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCTT 251
            :|. |..|:......: ||:......|:..|.||||.....:...:.|..||.|.:.||.:.|..
  Fly   131 EAWHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAK 195

  Fly   252 FCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLCN 316
            |||||||.|||..|...|:.:||.||||..|....|..||:  ||.||:|.:|.|:.||:|.|||
  Fly   196 FCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGCE--HGHCDKPNQCVCQLGWKGALCN 258

  Fly   317 ECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEG 381
            ||::.|.|.||:|| ..|.|:|:..|||:.|:||||:|..|.|||:||||.||....|.|.||.|
  Fly   259 ECVLEPNCIHGTCN-KPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPG 322

  Fly   382 LSGEQCEIVEHPC--ATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLR 444
            .||:.||...:.|  ...||:|||||..:...:|
  Fly   323 YSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKT------------------------------- 356

  Fly   445 PEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDL- 508
                                        .:.|.||.||:|..||..:..|:..|| |.|.|.::
  Fly   357 ----------------------------GYKCHCANGWSGKMCEEKVLTCSDKPC-HQGICRNVR 392

  Fly   509 --IG----GFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAAL 567
              :|    |::||||..:.|..|.:.::.| :|:
  Fly   393 PGLGSKGQGYQCECPIGYSGPNCDLQLDNC-SPN------------------------------- 425

  Fly   568 TSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVG-QCRNGATCIDLVNDY 631
                        ||||...|  || |..|||..|:.|..|..|:|||:| ||.||.||||:||.|
  Fly   426 ------------PCINGGSC--QP-SGKCICPAGFSGTRCETNIDDCLGHQCENGGTCIDMVNQY 475

  Fly   632 RCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLE 696
            ||.|..||.|..|.:.:|.|...||.|||.|:::...:.|.|..|::|..|....:.|:..||..
  Fly   476 RCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDCSVDIDECSSGPCHN 540

  Fly   697 -GHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTRK 760
             |.|:|....:.|.|.....||.|:            |..:.:|:........||
  Fly   541 GGTCMNRVNSFECVCANGFRGKQCD------------EESYDSVTFDAHQYGATT---------- 583

  Fly   761 MAKPSGLPCS-----GHGSCEMSDVGTFCKCHVGHTGTFC---------EHNLNECSPNPCRNGG 811
            .|:..||..:     ...|..|..|.....|.|     ||         |.:..|......:|..
  Fly   584 QARADGLTNAQVVLIAVFSVAMPLVAVIAACVV-----FCMKRKRKRAQEKDDAEARKQNEQNAV 643

  Fly   812 ICL--DGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGG--TCMPGAPDKALQPHCRCAPGWTG 872
            ..:  :|.|.......:...||      ||..:|...:||  ..:....||::...|..|.  ..
  Fly   644 ATMHHNGSGVGVALASASLGGK------TGSNSGLTFDGGNPNIIKNTWDKSVNNICASAA--AA 700

  Fly   873 LFCAEAIDQCRGQPCHNGGTCES-----GAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCI 932
            ...|.|.|:|    ...||...|     .|....||.....:....::|.:   |.....|:...
  Fly   701 AAAAAAADEC----LMYGGYVASVADNNNANSDFCVAPLQRAKSQKQLNTD---PTLMHRGSPAG 758

  Fly   933 DGIGGYSCICPPGRHGLRCEILLSDPKSACQNASNTISPYTALNRSQNWLDIA---LTGRTEDDE 994
            ....|.|...|....|.|..:|  ...|.|               ||.|..:|   :.|......
  Fly   759 SSAKGASGGGPGAAEGKRISVL--GEGSYC---------------SQRWPSLAAAGVAGACSSQL 806

  Fly   995 NCNACVCENGTSRC---TNLWCGLPN 1017
            ...|.|..:|....   .::.||.|:
  Fly   807 MAAASVAGSGAGTAQQQRSVVCGTPH 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_524527.3	MNNL	83..238	CDD:462222	50/163 (31%)
		DSL	220..282	CDD:128366	28/61 (46%)
		EGF_CA	350..388	CDD:238011	21/37 (57%)
		EGF_CA	490..526	CDD:238011	13/42 (31%)
		EGF_CA	610..645	CDD:238011	22/35 (63%)
		EGF_CA	647..683	CDD:238011	12/35 (34%)
		EGF_CA	690..720	CDD:238011	9/30 (30%)
		EGF_CA	798..833	CDD:238011	6/36 (17%)
		EGF_CA	879..913	CDD:238011	8/38 (21%)
		EGF_CA	916..952	CDD:238011	8/35 (23%)
		VWC_out	<993..1053	CDD:214565	6/28 (21%)
Delta	NP_477264.1	MNNL	23..182	CDD:462222	50/163 (31%)
		DSL	164..226	CDD:128366	28/61 (46%)
		EGF_CA	291..329	CDD:238011	21/37 (57%)
		EGF_CA	337..372	CDD:238011	14/93 (15%)
		EGF_CA	453..488	CDD:238011	22/34 (65%)
		EGF_CA	492..526	CDD:238011	12/33 (36%)
		EGF_CA	529..564	CDD:238011	10/34 (29%)