DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ser and Notch4

DIOPT Version :9

Sequence 1:NP_001287558.1 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster
Sequence 2:NP_001002827.1 Gene:Notch4 / 406162 RGDID:1303282 Length:1961 Species:Rattus norvegicus


Alignment Length:999 Identity:276/999 - (27%)
Similarity:392/999 - (39%) Gaps:227/999 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   239 QCAVTYYNTTC--------TTFCR-----------------PRDDQFGHYACGSEGQKLCLNGWQ 278
            |||..:...||        |..|.                 |......|::|      .|.:|:.
  Rat    49 QCAPGFLGETCQFPDPCWDTQLCENGGSCQALLPTAPSSHSPTSPLTPHFSC------TCPSGFT 107

  Fly   279 GVNCE---EAICKAGCDPVHGKCD-----RPGECECRPGWRGPLC---NECMVYPGCKHGSCNGS 332
            |..|:   |.:|........|.|.     || :|.|.|||.|..|   :.|...|....|.|..:
  Rat   108 GDRCQSPLEELCPPSFCSNGGHCSVQVSGRP-QCSCEPGWTGEQCQLRDFCSANPCANGGVCLAT 171

  Fly   333 --AWKCVCDTNWGGILCDQDLNFCGTHE-PCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPC 394
              ..:|.|.|.:.|.:|::|:|.|.... ||..|.:|.||. ..::|.|..|..|.||::.:..|
  Rat   172 YPQIQCRCPTGFEGHICERDVNECFLEPGPCPRGTSCHNTL-GSFQCLCPVGQEGPQCKLRKGAC 235

  Fly   395 ATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLV 459
            ....|.|||||.|.....|...:.....|.:.:...:.....:|:        |..||::...  
  Rat   236 LPGTCLNGGTCQLVPEGDTTFHLCLCPPGFTGLNCEMNPDDCVRN--------QCQNGATCQD-- 290

  Fly   460 SLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDEC-AGGP--CEHGGTCIDLIGGFRCECPPEWH 521
            .||:          :||.|...|.|..|..:|||| |.||  |.:||||.:..|||.|.|...|.
  Rat   291 GLGT----------YTCLCPKTWKGWDCSEDIDECEAQGPPRCRNGGTCQNSAGGFHCVCVSGWG 345

  Fly   522 GDVCQVDVNECEAPHSAGIAANALLTTTATAIIGS-----NLSSTALLAAL-------------- 567
            |:.|..::::|       .||...|.:|....:||     ....|.||..|              
  Rat   346 GEGCDENLDDC-------AAATCALGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLRQPCHVNAQ 403

  Fly   568 --TSAVASTSLAI------------------------GPCINAKECRNQPGSFACICKEGWGGVT 606
              |:.:..::|.|                        .||.:...|.|.||||.|:|..|:.|..
  Rat   404 CSTNPLTGSTLCICQPGYSGPTCHQDLDECQMAQQGPSPCEHGGSCINTPGSFNCLCLPGYTGSR 468

  Fly   607 CAENLDDCVGQ-CRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFN 670
            |..:.::|:.| |..|:||:||:..::|.|..|.:||.||.:|:|||::||.|...|.|.:..|.
  Rat   469 CEADHNECLSQPCHPGSTCLDLLATFQCLCPPGLEGRLCEVEINECASNPCLNQAACHDQLNGFL 533

  Fly   671 CICPLGYSGSLCEEAKENCTPSPCLE-GHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEG 734
            |:|..|::|:.||:..:.|:.:||.. |||.:.|..::|.|.|...|..||.....|...||..|
  Rat   534 CLCLPGFTGARCEKDMDECSSAPCANGGHCQDQPGAFHCECLPGFEGPRCETEADECRSDPCPVG 598

  Fly   735 -----------CFANVSLATSATTTTTTTTTATTTRKMAK----------PSG----------LP 768
                       |................:.......:..:          |.|          .|
  Rat   599 ASCLDLPGAFLCLCRPGFTGQLCEVPLCSPILCQPGQQCQDQEHRAPCLCPDGSPGCVPAEDDCP 663

  Fly   769 CSGHGSCEMSDVGTFCKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRC 833
            |. ||.|:.|    .|.|:.|.||..||..|..|...||.:||.|......:.|.|::|:||..|
  Rat   664 CH-HGHCQRS----LCVCNEGWTGPECETELGGCLSTPCAHGGTCHPQPSGYNCSCLAGYTGLTC 723

  Fly   834 SERATGCYAGQCQNGGTCMPGAPDKALQPH---CRCAPGWTGLFCAEAIDQCRGQPCHNGGTCES 895
            ||..|.|::|.|.|||:|       ::.|.   |.|.|..||..|..|:|.|....|.|||||.|
  Rat   724 SEEITACHSGPCLNGGSC-------SIHPEGYSCTCPPSHTGPHCQTAVDHCASASCLNGGTCMS 781

  Fly   896 GAGWFRCVCAQGFSGPDCRINVN-ECSPQPCQGGATCIDGIGGYSCICPPGRHGLRCEILLS-DP 958
            ..|.|.|.||.||.|..|...:: .|:..||:..|||.|...|..|:|.||..|..|:.|:. ..
  Rat   782 KPGTFFCHCATGFQGLHCEKKIHPSCADNPCRNKATCQDTPRGARCLCSPGYTGSSCQTLIDLCA 846

  Fly   959 KSACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWCGLPNCYKVDP 1023
            :..|        |:||              |.........|:|..|   .|...|.||...:...
  Rat   847 RKPC--------PHTA--------------RCLQSGPSFHCLCHQG---WTGSLCDLPLSCQAAA 886

  Fly  1024 LSKSSNLSGVCKQHEVCVPALS-------------------ETCLSSPCNVRGDCRALEPSRRVA 1069
            :|:...:|.:|:...:|:...|                   ..|.|.|| :.|.....:|:..|.
  Rat   887 MSQGVEISNLCQNGGLCIDTGSSYFCRCPPGFEGKLCQDTVNPCTSKPC-LHGATCVPQPNGYVC 950

  Fly  1070 PPRLPAKSSCWPNQAVVNENCARL 1093
                    .|.|...  .:||:::
  Rat   951 --------QCAPGYE--GQNCSKV 964

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SerNP_001287558.1 MNNL 83..161 CDD:284966
DSL 220..282 CDD:279722 13/67 (19%)
EGF_CA 350..388 CDD:238011 14/38 (37%)
EGF_CA 490..526 CDD:238011 19/38 (50%)
EGF_CA 610..645 CDD:238011 13/35 (37%)
EGF_CA 647..683 CDD:238011 14/35 (40%)
EGF_CA 798..833 CDD:238011 12/34 (35%)
EGF_CA 879..913 CDD:238011 17/33 (52%)
EGF_CA 916..952 CDD:238011 13/36 (36%)
VWC_out <993..1053 CDD:214565 14/78 (18%)
Notch4NP_001002827.1 EGF_CA 191..>224 CDD:284955 12/33 (36%)
EGF_CA 311..349 CDD:238011 19/37 (51%)
EGF_CA 352..387 CDD:238011 9/41 (22%)
EGF_CA 429..470 CDD:238011 12/40 (30%)
EGF_CA 472..508 CDD:238011 13/35 (37%)
EGF_CA 511..546 CDD:238011 14/34 (41%)
EGF_CA 548..584 CDD:238011 11/35 (31%)
EGF_CA 588..622 CDD:238011 5/33 (15%)
EGF_CA <696..723 CDD:238011 10/26 (38%)
EGF_CA 765..800 CDD:238011 17/34 (50%)
EGF_CA <810..839 CDD:238011 12/28 (43%)
EGF_CA 892..924 CDD:238011 4/31 (13%)
EGF_CA 927..961 CDD:238011 9/44 (20%)
EGF_CA 966..1000 CDD:238011
EGF_CA 1002..1040 CDD:238011
Notch 1207..1242 CDD:278494
Notch 1245..1281 CDD:278494
NOD 1291..1337 CDD:284282
NODP 1376..>1415 CDD:284987
Ank_2 <1571..1656 CDD:289560
ANK 1625..1732 CDD:238125
ANK repeat 1626..1656 CDD:293786
Ank_2 1630..1723 CDD:289560
ANK repeat 1658..1690 CDD:293786
ANK 1687..1811 CDD:238125
ANK repeat 1692..1723 CDD:293786
Ank_2 1697..1789 CDD:289560
ANK repeat 1725..1756 CDD:293786
ANK repeat 1758..1789 CDD:293786
ANK repeat 1791..1827 CDD:293786
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166338545
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

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