DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and JAG2

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_002217.3	Gene:	JAG2 / 3714	HGNCID:	6189	Length:	1238	Species:	Homo sapiens

Alignment Length:	1406	Identity:	487/1406 - (34%)
Similarity:	641/1406 - (45%)	Gaps:	334/1406 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 IALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGC--SPCTTAFRLCL 131
            :.|:|.|.|......|.|||::..:.|.|..||:|.||  ..:.|.|:..||  ..|.|..|:||
Human    13 LLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACC--DGDGRTTRAGGCGHDECDTYVRVCL 75

  Fly   132 KEYQTTEQGASIS-TG-CSFGNATTKILGGSSFVL-------------------SDPGVGAIVLP 175
            ||||     |.:: || ||:|:..|.:|||:||.|                   .|||:  :|:|
Human    76 KEYQ-----AKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGL--VVIP 133

  Fly   176 FTFRWTKSFTLILQALDMYNTSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQC 240
            |.|.|.:|||||::|.|..|.:.|:.|.|||..|::|:|.|...||:|...|..|.:..::||:|
Human   134 FQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRC 198

  Fly   241 AVTYYNTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECE 305
            ...||:.||..|||||:|.||||.|...|.|.|::||.|..|:||:||.||:.:||.|..||||.
Human   199 DENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECR 263

  Fly   306 CRPGWRGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTA 370
            |..||:|..|:||:.||||.|||| ...|:|.|:|||||:|||:|||:||:|.||.:||||.|..
Human   264 CSYGWQGRFCDECVPYPGCVHGSC-VEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAE 327

  Fly   371 PDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSS 435
            ||:|||||.:|.||..||..||.|.:.||.|||:|
Human   328 PDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSC------------------------------ 362

  Fly   436 SMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCE 500
                  |..|.|                          |.|.|.:||:||||.::|||||..||.
Human   363 ------HEVPSG--------------------------FECHCPSGWSGPTCALDIDECASNPCA 395

  Fly   501 HGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLA 565
            .||||:|.:.||.|.||.:|.|..||:|.||||..
Human   396 AGGTCVDQVDGFECICPEQWVGATCQLDANECEGK------------------------------ 430

  Fly   566 ALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGATCIDLVND 630
                          ||:||..|:|..|.:.|.|..||.|:.|..|::||.|||::|.||.||||.
Human   431 --------------PCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNG 481

  Fly   631 YRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCL 695
            |:|.|..||.||.||.:.||||:|||.:||.|.|:...|:|.||.|:||.|||...:.|.||||.
Human   482 YQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCR 546

  Fly   696 EG-HCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCN--EGCFANVSLATSATTTTTTTTTATT 757
            .| .|.|....|||.||.|..||:|...|..|....|.  :||.::.......|..
Human   547 NGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAA--------- 602

  Fly   758 TRKMAKPSGLPCSGHGSCEMSDVGTF-CKCHVGHTGTFCEHNLNECSPNPCRNGGICLD------ 815
                   ||: |..||.|.....|.| |.|..|.|||:|..|:::|...||||||.|:|
Human   603 -------SGV-CGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFR 659

  Fly   816 --------GD------------------------GDFTCECMSGWTGKRCSERATGCYAGQCQNG 848
                    |:                        .||.|.|..||.||.|..|...|.|..|.||
Human   660 CFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNG 724

  Fly   849 GTCM-----------PG--------APDKALQPH----------------CRCAPGWTGLFCAEA 878
            |||.           ||        |.:.:..|:                |.|..||.|..|...
Human   725 GTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHN 789

  Fly   879 IDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICP 943
            .:.|...||:|||.|..|..||||.||.||:|||||||::||...||..||||:|.|.||.|.||
Human   790 TNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCP 854

  Fly   944 PGRHGLRCEILLSDPKSACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRC 1008
            |||.|.||:.::...:|.....       |......:|:           |:||:|.|.:|...|
Human   855 PGRAGPRCQEVIGFGRSCWSRG-------TPFPHGSSWV-----------EDCNSCRCLDGRRDC 901

  Fly  1009 TNLWCGLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRL 1073
            :.:|||...|...   .:...||..|...:.|:......||..||...|:|.|.|      ||..
Human   902 SKVWCGWKPCLLA---GQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEE------PPST 957

  Fly  1074 PAKSSCWPNQAVVNENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGML 1138
            |    |.|....::.||||||:....:.|.:|.:|..:||.:|.|.|.:.:.:..        :|
Human   958 P----CLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDR--------LL 1010

  Fly  1139 MVLCDLKTGTNDTVELTVSSSKLNDPQLPVAVGLLGELLSFRQLNGIQRRKELELQHAKLAALT- 1202
            ::|||..:.....||:.||.|...|  ||.:..:.|                  ..||.:||:|
Human  1011 VLLCDRASSGASAVEVAVSFSPARD--LPDSSLIQG------------------AAHAIVAAITQ 1055

  Fly  1203 --------SIVEVKLETARVADGSGHSLLIGVLCGVFIVLVGFSVFISLYWKQRLAYRTSSGMNL 1259
                    ::.|||:||. |..||...||:.||||.|.||....|.:.::|.::
Human  1056 RGNSSLLLAVTEVKVETV-VTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRK----------- 1108

  Fly  1260 TPSLDALRHEEEKSNNLQNEENLRRYTNPLKGSTSSLRAATGME------LSLNPAPELAASAAS 1318
                   |.:|.:.:.|..||:......||....:.:....|.:      .:..|.|..|..|..
Human  1109 -------RRKERERSRLPREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALP 1166

  Fly  1319 SSALHRSQPLFPPCDFERELDSSTGL-KQAHKRSSQILLHK 1358
            ..|.|.:..       |.|.|...|. ::....:.:.|.||
Human  1167 GPAGHAAVR-------EDEEDEDLGRGEEDSLEAEKFLSHK 1200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	34/81 (42%)
		DSL	220..282	CDD:279722	29/61 (48%)
		EGF_CA	350..388	CDD:238011	23/37 (62%)
		EGF_CA	490..526	CDD:238011	19/35 (54%)
		EGF_CA	610..645	CDD:238011	20/34 (59%)
		EGF_CA	647..683	CDD:238011	19/35 (54%)
		EGF_CA	798..833	CDD:238011	19/72 (26%)
		EGF_CA	879..913	CDD:238011	18/33 (55%)
		EGF_CA	916..952	CDD:238011	21/35 (60%)
		VWC_out	<993..1053	CDD:214565	17/59 (29%)
JAG2	NP_002217.3	MNNL	28..102	CDD:284966	34/80 (43%)
		DSL	178..240	CDD:279722	29/61 (48%)
		EGF_CA	307..345	CDD:238011	23/37 (62%)
		EGF	351..381	CDD:278437	16/91 (18%)
		EGF_CA	385..421	CDD:238011	19/35 (54%)
		EGF_CA	423..458	CDD:238011	17/78 (22%)
		EGF_CA	461..496	CDD:238011	20/34 (59%)
		EGF_CA	500..534	CDD:238011	19/33 (58%)
		EGF_CA	536..571	CDD:238011	16/34 (47%)
		EGF_CA	636..671	CDD:238011	11/34 (32%)
		EGF_CA	676..709	CDD:238011	8/32 (25%)
		EGF	716..746	CDD:278437	10/29 (34%)
		EGF_CA	757..787	CDD:238011	6/29 (21%)
		EGF_CA	789..824	CDD:238011	18/34 (53%)
		EGF_CA	827..863	CDD:238011	21/35 (60%)
		VWC_out	872..943	CDD:214565	19/91 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1114..1139		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1156..1238		13/52 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144850
Domainoid	1	1.000	108	1.000	Domainoid score	I6432
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	720	1.000	Inparanoid score	I634
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45993
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	1	1.000	-	-		FOG0003067
OrthoInspector	1	1.000	-	-		otm40250
orthoMCL	1	0.900	-	-		OOG6_105778
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4751
SonicParanoid	1	1.000	-	-		X2046
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.700