DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and Crb2

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001129233.1	Gene:	Crb2 / 366031	RGDID:	1309368	Length:	1283	Species:	Rattus norvegicus

Alignment Length:	1402	Identity:	303/1402 - (21%)
Similarity:	397/1402 - (28%)	Gaps:	634/1402 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 AGCDPVHGKCDRPGEC---ECRPGWR-------GPLCNE-----CMVYPGCKHGS-C-------N 330
            ||..|    .:.|..|   .|.||.|       |..|..     |...| |.||: |       |
  Rat    32 AGLVP----SETPNVCASDPCAPGTRCQATESGGFTCEPLELGGCAAQP-CHHGALCVPQGPDPN 91

  Fly   331 GSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCA 395
            |  ::|.|...:.|..|:.|::.|.: .||.|||||.|.| |.|.|.|..|.:|..||.....|:
  Rat    92 G--FRCYCVPGFQGPHCELDIDECAS-RPCHHGGTCRNLA-DHYECHCPLGYAGVTCEAEVDECS 152

  Fly   396 TRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVS 460
            :.||.:||:|                                            |:|..|
  Rat   153 SAPCLHGGSC--------------------------------------------LDGVGS----- 168

  Fly   461 LGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPE-WHGDV 524
                         :.|.||.|:.|.:|::::|||...||||||.|.||:.||||:|... :.|..
  Rat   169 -------------YRCVCAPGYAGASCQLDVDECQSQPCEHGGVCHDLVNGFRCDCADTGYEGAR 220

  Fly   525 CQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRN 589
            |:.:|.||                                            |..||::...|.:
  Rat   221 CEQEVLEC--------------------------------------------ASAPCVHNASCLD 241

  Fly   590 QPGSFACICKEGWGGVTCAENLDDCVGQ-CRNGATC---------------------IDLVNDYR 632
            ...||.|:|..|:.|..|..:.|:|... |.||..|                     ......:.
  Rat   242 GFRSFRCLCWPGFSGERCEVDEDECASDPCHNGGRCSQRSDPTLYGGVQAIFPGAFSFSQAAGFL 306

  Fly   633 CACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLE- 696
            |:|..||.|.||..|::|||:.||.|||.|.|:...|.|.|..||:|..|:|..:.|...|||.
  Rat   307 CSCPPGFAGDDCSVDVNECASEPCLNGGSCQDLPNGFQCYCQDGYTGLTCQEDTDECQSEPCLHG 371

  Fly   697 GHCLNTPEGYYCHCPPDRAGKHCE-QLR-------PL----------------CSQPPCNEGCF- 736
            |.|.:|..||.|.||....|..|. ||.       ||                |...|...|.|
  Rat   372 GTCSDTVAGYICQCPEAWGGHDCSVQLTGCQGHACPLAATCIPTFKSGFHSYICRCLPGTYGSFC 436

  Fly   737 -------------------ANVSLATSATTTTTTTTTATTTRKMAKPS----------------- 765
                               |..|||.:....||....|..|.|.::.|
  Rat   437 DQNTTFSVVSGSSVWGLVPAGASLAFALRFRTTLLAGALATLKDSRDSLELVLVGAMLQATLWRR 501

  Fly   766 -------GLP----CSGH----------GSCEM-----SDVGTFC-------------------- 784
                   .||    ..||          |:.|:     ...|..|
  Rat   502 GTADLVLTLPDLALNDGHWHQVEVTLRLGTLELRLWHEGCPGQLCVVSGTVATDPTASVASGSPE 566

  Fly   785 --KCHVG---HTGTF----------------------CEHNLNECSPNPCRNGGICLDGDGDFTC 822
              ..|:|   ..|.|                      ||.. ..|.|.||.|||.|:|...||.|
  Rat   567 PYSIHLGGRAFAGCFQDVRVEGHLLLPEELKGSVLLGCERT-EPCQPLPCANGGACVDLWTDFRC 630

  Fly   823 ECMSGWTGKRCSERATGCYAG------------------------------------QCQNGGTC 851
            :|...:.|.:|::.......|                                    |..|....
  Rat   631 DCPRPYHGSKCTDEVPAATFGLGGVMSSATFLLHQMLGPNLTVSFFLRTREPASLLLQFANDSVA 695

  Fly   852 ----------------------MPGAPDKALQPHC---------------------RCAPG---- 869
                                  :||..|..|: |.                     |..|.
  Rat   696 SLTVSLSEGQIRAEVLGHPAVILPGRRDDGLR-HLVVLSFGPDQLQDLGQWLYVGGRLYPDDTQP 759

  Fly   870 WTGLF--CAEAI--------------------------------------DQCRGQPCHNGGTCE 894
            |.|.|  |.:.:                                      |.|...||.|||||.
  Rat   760 WGGPFRGCLQDLQLNGIHLPFFSSPMENSSWPSELEAGQSSNLTQGCVSEDTCNPNPCFNGGTCH 824

  Fly   895 SGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCIC-------PPG------- 945
            .....|.|.|...|:||.| .....|..|||...|||.:...|:.|:.       ||.
  Rat   825 ITWNDFYCTCPDNFTGPTC-AQQRWCPRQPCLPPATCEEVPDGFVCVAEATFREGPPAVFTGHNV 888

  Fly   946 ---------------------------------------RHGLRC-----EILLSDPKSACQNAS 966
                                                   |:||..     .:|.:........|.
  Rat   889 SSSRALSRVTLAFRTRDLEAGLLRAASAAGAHSNIWLAVRNGLLAVDVAGSVLPAPGPRVADGAW 953

  Fly   967 NTIS-----PYTALNRSQNWLD-----IALTGRTED--------------DENCNACV------- 1000
            :.:.     |..|.:|...|||     :||.|...|              .||...|:
  Rat   954 HRVRLAREFPQAAASRWLLWLDGAATPVALHGLGGDLGFLQGPGAVPLLLAENFTGCLGRVALGD 1018

  Fly  1001 -----------CENGTSRCTNLWCGLPNCYKVDPLSKSSNLSGVCKQHEVCVPA----------- 1043
                       ..:|.......|.|.|....:.           |:...||.|:
  Rat  1019 LPLPLAPPRSGAMSGAREHFMAWPGSPPAVSLG-----------CRGGPVCTPSPCLHGGACLDL 1072

  Fly  1044 -------------------LSETCLSSPCNVRGDCRALEPSRRV---APP-------RLPAKSSC 1079
                               .::.|.|||| |||.|.. .|..|.   .||       |||.
  Rat  1073 FDVFACSCGPAWEGPRCEIHADPCRSSPC-VRGQCNT-RPDGRFECRCPPGFSGPRCRLPT---- 1131

  Fly  1080 WPNQAVVNENCARLTILLALERVGKGASVEG-----LCSLVRVL--LAAQLIKKPASTFGQDPGM 1137
            .|....:|..|.            .||...|     .||....|  |..|.:.:|...   .|.:
  Rat  1132 LPQGCSLNSTCK------------DGAPCGGGPLGTNCSCQEGLAGLRCQSLDQPCEA---SPCL 1181

  Fly  1138 LMVLCDLKTGTNDTVELTVSSS--------------KLNDPQLPVAV------------GLLGEL 1176
            ....|.:.:|   ..|.|.|:.              .|..|.|.|||            |||..:
  Rat  1182 NGGTCRVTSG---IFECTCSAGFSGQFCEVVKTLPLPLPFPLLEVAVPAACACLLLLLLGLLSGI 1243

  Fly  1177 LSF---RQLNGIQRRKELELQHAKLAALTSIVEVKLE 1210
            |:.   ||..|.....:.|:..|:| .:.|:::|..|
  Rat  1244 LAARKRRQSEGTYSPSQQEVAGARL-EMDSVLKVPPE 1279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011	17/37 (46%)
		EGF_CA	490..526	CDD:238011	18/36 (50%)
		EGF_CA	610..645	CDD:238011	12/56 (21%)
		EGF_CA	647..683	CDD:238011	17/35 (49%)
		EGF_CA	798..833	CDD:238011	14/34 (41%)
		EGF_CA	879..913	CDD:238011	15/71 (21%)
		EGF_CA	916..952	CDD:238011	14/93 (15%)
		VWC_out	<993..1053	CDD:214565	14/107 (13%)
Crb2	NP_001129233.1	EGF_CA	<76..107	CDD:238011	10/33 (30%)
		EGF_CA	109..145	CDD:238011	17/37 (46%)
		EGF_CA	148..183	CDD:238011	14/96 (15%)
		EGF_CA	185..222	CDD:238011	18/36 (50%)
		EGF_CA	227..260	CDD:238011	12/76 (16%)
		EGF_CA	321..357	CDD:238011	17/35 (49%)
		EGF_CA	359..394	CDD:238011	13/34 (38%)
		Laminin_G_2	466..589	CDD:280389	18/122 (15%)
		EGF_CA	<614..642	CDD:238011	12/27 (44%)
		LamG	657..774	CDD:238058	13/117 (11%)
		EGF_CA	814..843	CDD:238011	13/28 (46%)
		LamG	901..1021	CDD:304605	18/119 (15%)
		EGF_CA	1176..1207	CDD:238011	6/36 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900