DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and egas-4

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_501207.2	Gene:	egas-4 / 3564809	WormBaseID:	WBGene00018906	Length:	883	Species:	Caenorhabditis elegans

Alignment Length:	1070	Identity:	233/1070 - (21%)
Similarity:	342/1070 - (31%)	Gaps:	405/1070 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 DRPGEC----ECRPGWR--GPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTH 357
            |.|.:|    .|.|..|  ...|:||.    |...|...|...|...|:            |..:
Worm    16 DTPYDCGAHGYCYPANRTSATTCSECT----CSDESTQTSDTTCTAPTS------------CSPN 64

  Fly   358 EPCKHGGTCENTAPDKYRCTCAEGLSGEQCE-IVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTS 421
             ||.......|...|...||||.|.:|..|. :...||:.:||...|.|
Worm    65 -PCTLSNQQCNMVNDIPTCTCAVGYTGTDCTMLTSDPCSPQPCLQNGVC---------------- 112

  Fly   422 HGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPT 486
                                           |||.|               .::|.||.|:.|..
Worm   113 -------------------------------SSSGG---------------TYSCACATGFFGEQ 131

  Fly   487 CEINIDECAGGPCEHGGTCIDLIGGFR--CECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTT 549
            |:.:.|.|: |.|.:||||..|.....  |:||.:::||.||                    ||.
Worm   132 CQYSGDPCS-GYCSNGGTCEMLFSDTTPYCQCPFDYYGDKCQ--------------------TTR 175

  Fly   550 A--TAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLD 612
            :  |:.:|....|:|..:  ...|.||::..|     .:||:...|:    :|.
Worm   176 SVQTSYVGCFDDSSASFS--DYYVYSTTITTG-----TDCRDALISY----REA----------- 218

  Fly   613 DCVGQCRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGY 677
                         :..::|..:..||..| :|........|.|...||..|.::......|  .|
Worm   219 -------------NPTSNYAYSTMSGTTG-ECLFSTANALTDPPTGGGLLVALLNALLSTC--AY 267

  Fly   678 SG-----SLCEEAKENCTPSPCLE----GHCLNT-PEGYYCHCPPDRAGKHCEQLRPLCSQPPCN 732
            |.     :......:.|||.||.|    |.|:.| ...|.|.|.|.:.|..|:
Worm   268 SNLNSGFAAVYSLNDLCTPEPCGEAAGNGKCIQTSATAYTCLCNPIKTGSACQ------------ 320

  Fly   733 EGCFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCS----GHGSCEMSD--VGTFCKCHVGHT 791
                      :.||.|                   ||:    |.|:|.::|  :|.:|.|...:.
Worm   321 ----------SDATLT-------------------PCASIDCGVGTCGVTDDQIGYYCLCASTNQ 356

  Fly   792 GTFCEHNLNECSPNPCRNGGICLD-GDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMP-- 853
            ...|..  |.|:..||..||.|.| |:|.::|.|::.:....| |....||..:|:|||||:|
Worm   357 TVACVG--NPCTSEPCLYGGTCSDLGNGSYSCACLNLYMDTNC-ETFDSCYINKCENGGTCVPTY 418

  Fly   854 GAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCESGAG---WFRCVCAQGFSGPDCRI 915
            ...|....  |:|.|.|.|.:|.|....|...||.|||.||...|   .:.|.|...::|.:|.|
Worm   419 NLLDSTFT--CQCTPDWKGTYCEEERYYCDETPCENGGECEDIIGPPNSYNCTCTPQWTGFNCTI 481

  Fly   916 NVNECSPQP--CQ---GGATCIDGIGGYSCICPPGRHGLRC------------------------ 951
            :|:||....  |:   ..|||::..|.|.|:|.|...|..|
Worm   482 DVDECVEDTTLCKTKDPDATCVNTNGSYYCVCSPNMFGKSCLFNKIIYQILNATYGDLGPDKLDE 546

  Fly   952 --EILLSDPKSACQNASNTISPYT-ALNRSQNW--LDIALTGRTED---DENCNACVCENGTSRC 1008
              :.|.:||..........|..|: .:..|.:|  .|:.|....|.   |.|.|.....:..
Worm   547 MAQELTNDPTLVRDIVPFLIGGYSLEVRTSLSWTAADMFLWVAYEQQLIDLNSNFVQWNDKV--- 608

  Fly  1009 TNLWCGLPNCYKVDPLSKS----SNLSGV---------CKQHE---------------------- 1038
                  |.||:..:.::.|    :..||.         .||.|
Worm   609 ------LGNCFTFNHMNSSFKYEARSSGYPGGLEMQMNVKQDEYLPWTETAGVMVFTSTKEEAVT 667

  Fly  1039 -------------------------------VCVPALSET-------------CLSSPCN---VR 1056
                                           ||:.::||.             ||.| |.   |.
Worm   668 SESVRINTAPHFESRIAINRVDYYRLGGRYGVCINSVSEVKSYYYDGDYTTDGCLRS-CYQDVVN 731

  Fly  1057 GDCRALEPSRRVAPPRLP----------AKSSC-------------WP--------NQAVVNENC 1090
            |||..::       ||.|          ::.:|             ||        :|.|.....
Worm   732 GDCGCMD-------PRYPMPNDGISCSISQKTCIDELVDSRGDPSTWPECTCPLPCSQTVYTSKL 789

  Fly  1091 ARLTILLALERVGKGASVEGLC---SLVRVLLAAQLIKKPASTFGQDPGMLMVLCDLKTGTNDTV 1152
            :||..:..:....:..:.:..|   .|..|:|...|.|.....:.:.|.|
Worm   790 SRLPYVNKIVDCEEAYTNKTACYETFLDSVILRISLPKLDYMIYSETPAM--------------- 839

  Fly  1153 ELTVSSSKLNDPQLPVAVGLLGELLSFRQL 1182
            :||...|.|.. .|.:.:|:  .::||.:|
Worm   840 DLTKFMSYLGG-ILSILIGV--SIVSFVEL 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011	11/37 (30%)
		EGF_CA	490..526	CDD:238011	14/37 (38%)
		EGF_CA	610..645	CDD:238011	4/34 (12%)
		EGF_CA	647..683	CDD:238011	8/40 (20%)
		EGF_CA	798..833	CDD:238011	12/35 (34%)
		EGF_CA	879..913	CDD:238011	12/36 (33%)
		EGF_CA	916..952	CDD:238011	14/66 (21%)
		VWC_out	<993..1053	CDD:214565	19/138 (14%)
egas-4	NP_501207.2	EGF	101..131	CDD:278437	14/91 (15%)
		EGF_CA	482..522	CDD:238011	13/39 (33%)
		ASC	<610..869	CDD:279230	47/283 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000