DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and ft

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_477497.1	Gene:	ft / 33627	FlyBaseID:	FBgn0001075	Length:	5147	Species:	Drosophila melanogaster

Alignment Length:	1349	Identity:	264/1349 - (19%)
Similarity:	400/1349 - (29%)	Gaps:	499/1349 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   400 RNGGTCTLKTS-NRTQAQVYRTSHGRSNMGRPVRRS---------------SSMRSLDHLRPEGQ 448
            ||.|.....|| :|....:........:.|:|.::|               |:.||| |:   ..
  Fly  3704 RNSGVVRSTTSFDREMTPILEAIIEVEDSGKPKQKSQHLLTITVLDQNDNPSTTRSL-HI---AV 3764

  Fly   449 ALNGSSSPGLVSLGSL--------------------QLQQQLAPDFTCDCAAGWTGPTCEI-NID 492
            :|.....|..|.|..:                    |.|.|||....||...  |..|..| ::.
  Fly  3765 SLFNGDLPSNVKLADVRPNDIDIVGDYRCRLQKNPAQSQLQLAIPRACDLIT--TSHTTPIASVF 3827

  Fly   493 ECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAAN----------ALLT 547
            ...|...:||.....:...|: ....|...:...:.|....|.|   ..||          :.::
  Fly  3828 SYTGNDGKHGDVSSKVSVAFQ-SFNNETLANSVSIMVRNMTAYH---FLANHYRPILEMIKSRMS 3888

  Fly   548 TTATAII-----GSNLSSTALLAALTSAVASTS-------------------------LAIG--P 580
            .....|:     |.:.:||.|...:...:|.||                         :.:|  |
  Fly  3889 NEDEVILYSLLEGGSGNSTNLQLLMAVRLAKTSYQQPKYLIERLREKRSAFSELLQKEVIVGYEP 3953

  Fly   581 CINAKECRN--------------------QPG----------SFACICKEGWGGVTCAENLDDCV 615
            |.....|.|                    .|.          .::|.|..|:.|..|:...|.|:
  Fly  3954 CSEPDVCENGGVCSATMRLLDAHSFVIQDSPALVLSGPRVVHDYSCQCTSGFSGEQCSRRQDPCL 4018

  Fly   616 -GQCRNGATCIDLVNDYRCACASGFKGRDCETD-IDECATSPCRNGGECVDMV--GKFNCICPLG 676
             ..|.:...|..|.:|::|.|.:...|:.||.: .|.|.:.||||||.|....  ..:.|:|..|
  Fly  4019 PNPCHSQVQCRRLGSDFQCMCPANRDGKHCEKERSDVCYSKPCRNGGSCQRSPDGSSYFCLCRPG 4083

  Fly   677 YSGSLCEEAKENCTPSPCLEGH-CLNTPEGYYCHCPPDRAGKHCEQ----LRPLCSQP-PCNEGC 735
            :.|:.||...::|.|:|||.|. |::...||.|:|.|.|.|:|||:    .:||.... |
  Fly  4084 FRGNQCESVSDSCRPNPCLHGGLCVSLKPGYKCNCTPGRYGRHCERFSYGFQPLSYMTFP----- 4143

  Fly   736 FANVSLATSATTTTTTTTTATTTRKMAKPS-------GLPCSG----------HGSCEMSDVGTF 783
                  |...||...:...|||     ||:       |:...|          ||....|..|
  Fly  4144 ------ALDVTTNDISIVFATT-----KPNSLLLYNYGMQSGGRSDFLAIELVHGRAYFSSGG-- 4195

  Fly   784 CKCHVGHTGTFCEHNLNE---CSPNPCRNGGI-------CLDGDGDFTCECMSGWTGKRCSERAT 838
              .....:......||.:   ......|||.:       |.| .||...||:.|         .:
  Fly  4196 --ARTAISTVIAGRNLADGGWHKVTATRNGRVMSLSVAKCAD-SGDVCTECLPG---------DS 4248

  Fly   839 GCYAGQCQNGGT-------CMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQ----------- 885
            .|||.:....||       .|.|                 ||..|:.|.:..||
  Fly  4249 SCYADEVGPVGTLNFNKQPLMIG-----------------GLSSADPILERPGQVHSDDLVGCLH 4296

  Fly   886 PCHNGGTC--------ESG--AGWFRCVCAQGFSGPDCRINVNECSPQPCQGG--ATCIDGIGGY 938
            ..|.||..        :.|  ||..|..|....:...|             ||  ..|||.....
  Fly  4297 SVHIGGRALNLSLPLQQKGILAGCNRQACQPALAAERC-------------GGFAGQCIDRWSSS 4348

  Fly   939 SCICPPGRHGLRCEILLSDPKSACQNASNTISPYT-----------------------ALNRSQN 980
            .|.|  |.|       |..|     :.|:::.|.|                       ..|....
  Fly  4349 LCQC--GGH-------LQSP-----DCSDSLEPITLGEGAFVEFRISEIYRRMQLLDNLYNSKSA 4399

  Fly   981 WLD-------------------------IALTGRTEDDE-------------------------- 994
            |||                         :::..||..|:
  Fly  4400 WLDNQQMRERRAVSNFSTASQIYEAPKMLSMLFRTYKDQGQILYAATNQMFTSLSLREGRLVYYS 4464

  Fly   995 ----NCNACVCENGTSRCTNLWCGLPNCYKVDPLSKSSNL---------------SGVCKQHEVC 1040
                ..|..|.|..|.. ...|      :.|...|:|.:|               :||   |:..
  Fly  4465 KQHLTINMTVQETSTLN-DGKW------HNVSLFSESRSLRLIVDGRQVGDELDIAGV---HDFL 4519

  Fly  1041 VPALS---------ETCLSSPCNVRGDCRALEPSRRVAPP-RLPAK--SSCWPNQAVVNENCARL 1093
            .|.|:         ..||:: ..|..:.:.|..|..:.|. |...|  |.|   :..:.::.|::
  Fly  4520 DPYLTILNVGGEAFVGCLAN-VTVNNELQPLNGSGSIFPEVRYHGKIESGC---RGDIGQDAAQV 4580

  Fly  1094 TILLALERVGKGASVEGLCSLVRVLLAAQL----------------------IKKPASTFGQDPG 1136
            ...|:   :|....:.....||..:|.:.:                      ||.|.....|...
  Fly  4581 ADPLS---IGFTLVIVFFVILVVAILGSYVIYRFRGKQEKIGSLSCGVPGFKIKHPGGPVTQSQV 4642

  Fly  1137 MLMVLCDL--------KTGTNDTVELTVSSSKLNDPQL-------PVAVGLLGELLSFRQLNGIQ 1186
            ..:::.:|        ..|..|.:...|.|..|..|:|       |.|     |:...:|.....
  Fly  4643 DHVLVRNLHPSEAPSPPVGAGDHMRPPVGSHHLVGPELLTKKFKEPTA-----EMPQPQQQQQRP 4702

  Fly  1187 RRKE----------------------LELQHAKLAALTSIVEVKLETARVADGSGHSLLIGVLCG 1229
            :|.:                      |.|:||      |.|::..|.....|....|
  Fly  4703 QRPDIIERESPLIREDHHLPIPPLHPLPLEHA------SSVDMGSEYPEHYDLENAS-------- 4753

  Fly  1230 VFIVLVGFSVFISLYWKQRLAYRTSSGMN----LTPSLDALRHEEEKSNNLQNEENLRRYTNPLK 1290
               .:....:.|..::|   .||.::|:.    ..|.:.|..|.:.:::..|.::...|:|.|.
  Fly  4754 ---SIAPSDIDIVYHYK---GYREAAGLRKYKASVPPVSAYTHHKHQNSGSQQQQQQHRHTAPF- 4811

  Fly  1291 GSTSSLRAATGMELSLNPAPELAASAASSSALHRSQPLFPPCDFERELDSSTGLKQAHKRSSQIL 1355
                         ::.|...:......|:|..|:|.||       ..|..|:.|.....|.  :.
  Fly  4812 -------------VTRNQGGQPPPPPTSASRTHQSTPL-------ARLSPSSELSSQQPRI--LT 4854

  Fly  1356 LHKTQNSDMRK---NTVGSLDSPRKDF---GKRSINCKSMPPSSGDEGS 1398
            ||......::.   .|..|.....||.   .:||:|...|...||...|
  Fly  4855 LHDISGKPLQSALLATTSSSGGVGKDVHSNSERSLNSPVMSQLSGQSSS 4903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011
		EGF_CA	490..526	CDD:238011	5/35 (14%)
		EGF_CA	610..645	CDD:238011	9/35 (26%)
		EGF_CA	647..683	CDD:238011	13/38 (34%)
		EGF_CA	798..833	CDD:238011	12/44 (27%)
		EGF_CA	879..913	CDD:238011	11/54 (20%)
		EGF_CA	916..952	CDD:238011	9/37 (24%)
		VWC_out	<993..1053	CDD:214565	17/113 (15%)
ft	NP_477497.1	Cadherin_repeat	71..152	CDD:206637
		Cadherin_repeat	163..266	CDD:206637
		Cadherin_repeat	275..378	CDD:206637
		Cadherin_repeat	393..490	CDD:206637
		Cadherin_repeat	498..594	CDD:206637
		Cadherin_repeat	603..704	CDD:206637
		Cadherin_repeat	735..814	CDD:206637
		Cadherin	843..>907	CDD:278457
		Cadherin	950..1026	CDD:278457
		Cadherin_repeat	1053..1149	CDD:206637
		Cadherin_repeat	1157..1274	CDD:206637
		Cadherin_repeat	1282..1380	CDD:206637
		Cadherin_repeat	1390..1485	CDD:206637
		Cadherin_repeat	1497..1597	CDD:206637
		Cadherin_repeat	1621..1699	CDD:206637
		Cadherin_repeat	1720..1818	CDD:206637
		Cadherin_repeat	1827..1918	CDD:206637
		Cadherin_repeat	1926..2023	CDD:206637
		Cadherin_repeat	2031..2162	CDD:206637
		Cadherin_repeat	2172..2274	CDD:206637
		Cadherin_repeat	2282..2380	CDD:206637
		Cadherin_repeat	2388..2487	CDD:206637
		Cadherin_repeat	2495..2592	CDD:206637
		Cadherin_repeat	2600..2694	CDD:206637
		Cadherin_repeat	2710..2806	CDD:206637
		Cadherin_repeat	2814..2909	CDD:206637
		Cadherin_repeat	2917..3009	CDD:206637
		Cadherin	3018..3114	CDD:278457
		Cadherin	3129..3220	CDD:278457
		Cadherin_repeat	3233..3330	CDD:206637
		Cadherin_repeat	3338..3434	CDD:206637
		Cadherin_repeat	3443..3541	CDD:206637
		Cadherin_repeat	3550..3647	CDD:206637
		Cadherin_repeat	3657..3753	CDD:206637	9/48 (19%)
		EGF	4017..4047	CDD:278437	8/29 (28%)
		EGF_CA	4056..4090	CDD:238011	12/33 (36%)
		EGF_CA	4094..4128	CDD:238011	15/33 (45%)
		Laminin_G_1	4156..4306	CDD:278483	39/185 (21%)
		LamG	4428..4543	CDD:238058	19/125 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910