DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and yl

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster

Alignment Length:	1205	Identity:	239/1205 - (19%)
Similarity:	381/1205 - (31%)	Gaps:	428/1205 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 GCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCE-----NTAPDKYRCTCAE-- 380
            ||::.:|:                     :.|...||...|.:|.     ..|||..||...|
  Fly   663 GCENATCS---------------------HLCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEKR 706

  Fly   381 -----GLSGEQCEIVEHPC---------ATRPCR---------NGGTCTLKTSNRTQAQVYRTSH 422
                 || |:....:||..         .|.||.         ||.........|...:....||
  Fly   707 QRLFIGL-GQVLLEIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQRLILEFQPESH 770

  Fly   423 G-----RSNMGRPVRRSSSMRSLDHLRPEGQALN---GSSSPGLVSLGSLQLQ----------QQ 469
            .     |||:|     :.|..:.|||     :.|   ..:...::.:.|||.:          |:
  Fly   771 ESNVLVRSNLG-----NVSALAFDHL-----SRNLYWADTERAVIEVLSLQTRHRALIRFFPGQE 825

  Fly   470 LAPDFTCDCAAGW------------------TGPTCEINIDECAGGPCEHGGTCIDLIGGFRCEC 516
            :....|...|.|:                  :|...::::.|     .:.|...|.|:..:..:.
  Fly   826 VPIGLTVMPAEGYLYVVLKAKRHSHIDKIPLSGKGEQVHVFE-----DDLGDDDIKLVTDYETQT 885

  Fly   517 PPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAII------------------GSNLSSTAL 563
            ......|:.::..:....|||. |....|....:.|::                  .||:....:
  Fly   886 IFWSDSDLGRISYSNYRVPHSQ-IFRGKLRRPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKV 949

  Fly   564 L--------AALTSAV---------ASTSLAIGPCINAKECRNQPGSFA------------CICK 599
            :        ||:...|         .:.|..:|.  .:..|:.|.|..:            |:|.
  Fly   950 IDIMEKDDPAAIMPYVPVATPNGIPLAASSPVGQ--ESHPCQQQNGGCSHICVGEGPYHSICLCP 1012

  Fly   600 EGW-----GGVTCAENLDDCVGQCRNG------------ATCIDLVNDYRC-------------- 633
            .|:     |..||.|.| ||..:|.:|            ..|:|..::..|
  Fly  1013 AGFVYRDAGNRTCVEAL-DCEFRCHSGECLTMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSP 1076

  Fly   634 ---ACASGFK----------GRDCETDIDE--C----ATSPCR------NGGECVDMV----GKF 669
               ||.||.:          .:||....||  |    .:..|.      :.|:|||..    |..
  Fly  1077 NQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCEKFDKSKKCHVHQHGCDNGKCVDSSLVCDGTN 1141

  Fly   670 NC-------ICPLGYSGSLCEEAKENCTPSPCLEG--HC---LNTPEGYYCH-------CPPDR- 714
            :|       :|.   :.|.||.....|....|:.|  .|   ::..:|...|       ||||.
  Fly  1142 DCGDNSDELLCE---ATSRCEPGMFQCGSGSCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQ 1203

  Fly   715 ---AGKHCEQLRPLC-SQPPCNEGCFANVSLATSATTTTTTTT----TATTTRKMAKPSGLPCSG 771
               .|: |.....:| ....|.:.. ..::..|.::|...:..    ..|:..|:..||.:.|:|
  Fly  1204 RCLLGQ-CLDRSLVCDGHNDCGDKS-DELNCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCNG 1266

  Fly   772 HGSC----EMSDVGTFC-----KCHVGHTGTFCEHNLNECSPNPCRNGG--ICLDGDGDFTCECM 825
            ...|    :.:|.|..|     ||..|          .||.....|..|  .|.||..:.:||..
  Fly  1267 TTECPRGEDEADCGDVCSIYEFKCRSG----------RECIRREFRCDGQKDCGDGSDELSCELE 1321

  Fly   826 SG---------W--TGKRCSERATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGW-TGLFCAEA 878
            .|         |  :.:.|......|..|:|.:........||        |..|. .|..||.|
  Fly  1322 KGHHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLSRVCNNFPD--------CTNGHDEGPKCATA 1378

  Fly   879 IDQCRG-QPCHNGGTCESGAGWFRCVCAQGF----SGPDCRINVNEC-SPQPCQGGATCIDGIGG 937
            .....| |.|.:  .|.:......|.|..|:    ....| ::::|| ..|||  ...|.:.:||
  Fly  1379 CRSASGRQVCQH--KCRATPAGAVCSCFDGYRLDADQKSC-LDIDECQEQQPC--AQLCENTLGG 1438

  Fly   938 YSCICPPGRHGLRCEILLSDPKSACQN-ASNTISPYTALNRSQN-----------WL--DIALTG 988
            |.|.|       ..:.:|...:.:|:: .|.....:::.|..:|           |.  |..:||
  Fly  1439 YQCQC-------HADFMLRQDRVSCKSLQSGATLLFSSFNEVRNLSEQPVMLNVAWSANDSRITG 1496

  Fly   989 ------------RTEDDENCNACVCENGTSRCTNLWCGLPNCYKVDPLSKSSNLSGVCKQHEVCV 1041
                        ..||:                    |:  .|::|            .|.:|.|
  Fly  1497 FDLAMHRQMGYFSAEDE--------------------GI--VYQID------------LQTKVIV 1527

  Fly  1042 PALSETCLSSPCN-----VRGDCRALEPSRRVAPPRLPAKSSCWPNQAVVNENCARLTILLALER 1101
            .||.   |.:|..     |.|:...|..::.:        .:|    :.|...|.|:..:.:...
  Fly  1528 RALG---LPAPTKLSVDWVTGNVYVLSGAQEI--------QAC----SFVGRMCGRIVHVKSPRH 1577

  Fly  1102 VGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGML-MVLCDLKTGTNDTVELTVSSSKL---- 1161
            | |..:|:|..:.:..::..      ...:||....: |...|   |:...:.|..|.|.:
  Fly  1578 V-KHLAVDGYHARIFYIVIR------TEGYGQTSSEIHMARLD---GSRRDMLLQRSESFMTALT 1632

  Fly  1162 NDP--QLPVAVG---LLGELLSFRQLNGIQRRKELELQ----------------HAKLAALTSI- 1204
            .||  ||...|.   ...|.:|:|...|..||.|:.||                :|.:..|.|:
  Fly  1633 TDPHQQLLYFVDQHMRTLERISYRLKTGPMRRPEIMLQKSNALMHPSGLSVYENNAFIVNLGSVE 1697

  Fly  1205 -VEVKLETARVADGSGHSLLIGVLCGVFIVLVGFS 1238
             |:..|..:|:.    |.:.|.||....||:.|.|
  Fly  1698 AVQCALYGSRIC----HKISINVLNAQDIVVAGRS 1728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011	14/49 (29%)
		EGF_CA	490..526	CDD:238011	5/35 (14%)
		EGF_CA	610..645	CDD:238011	13/73 (18%)
		EGF_CA	647..683	CDD:238011	12/58 (21%)
		EGF_CA	798..833	CDD:238011	11/47 (23%)
		EGF_CA	879..913	CDD:238011	7/38 (18%)
		EGF_CA	916..952	CDD:238011	11/36 (31%)
		VWC_out	<993..1053	CDD:214565	9/59 (15%)
yl	NP_996433.1	LDLa	90..124	CDD:238060
		LDLa	131..166	CDD:238060
		LDLa	184..216	CDD:238060
		LDLa	227..262	CDD:238060
		LDLa	271..302	CDD:238060
		FXa_inhibition	352..387	CDD:291342
		Ldl_recept_b	442..482	CDD:278487
		LY	466..508	CDD:214531
		Ldl_recept_b	529..569	CDD:278487
		LY	553..595	CDD:214531
		LY	596..637	CDD:214531
		FXa_inhibition	669..700	CDD:291342	9/51 (18%)
		LY	774..815	CDD:214531	12/50 (24%)
		LDLa	1032..1062	CDD:238060	4/29 (14%)
		LDLa	1074..1109	CDD:238060	8/34 (24%)
		LDLa	1118..1152	CDD:238060	7/33 (21%)
		LDLa	1157..1189	CDD:197566	7/31 (23%)
		LDLa	1198..1232	CDD:238060	8/35 (23%)
		LDLa	1243..1279	CDD:238060	7/35 (20%)
		LDLa	1283..1318	CDD:238060	11/44 (25%)
		LDLa	1340..1371	CDD:197566	8/38 (21%)
		FXa_inhibition	1388..1416	CDD:291342	5/29 (17%)
		EGF_CA	1418..1452	CDD:214542	12/42 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910