DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and nid2a

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_005169904.1	Gene:	nid2a / 322921	ZFINID:	ZDB-GENE-030827-2	Length:	1804	Species:	Danio rerio

Alignment Length:	1415	Identity:	302/1415 - (21%)
Similarity:	452/1415 - (31%)	Gaps:	538/1415 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 LEISNTNSHLLNGYCCGMPAELRATKTIGCSPCTTAFRLCLKEYQTTEQGASISTGC---SFGNA 152
            ||:.|:    |||:.. ..||......:..||...  ||.:  .||       :||.   ::.|.
Zfish   543 LELPNS----LNGFSI-TGAEFTRRADVTFSPGNQ--RLSI--VQT-------ATGLDNQNYLNV 591

  Fly   153 TTKILGGSSFVLSDPGVGAIVLPFTFRWTKSFTLILQALDMYNTSYPDAERLIEETSYSGVILPS 217
            .|.:.|...|:  .||....:.||.              |.|. .||.   ||..||..
Zfish   592 DTHLQGSVPFI--PPGATVQMEPFK--------------DTYQ-YYPS---LITSTSVR------ 630

  Fly   218 PEWKTLDHIGRNARITYRVRVQCAVTYYNTTCTTFCRP-------------------RDDQFGHY 263
             |:|.:.  ..|...|:..:|:..:||.:  |:.  ||                   |:::...|
Zfish   631 -EFKVVS--AENGAETFTFQVKQNITYRD--CSH--RPRSRLETLELKMERVFVMYVREERILRY 688

  Fly   264 ACGS------------EGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLCN 316
            |..:            |....|.:|  ..:|:..   |.|.|..|:.   ..|:|..|:||...|
Zfish   689 AITNKIGPLGAVDPEPENVNPCYSG--NHDCDTT---ARCVPGEGQL---FSCQCATGYRGDGRN 745

  Fly   317 ECMVYPGCKHG--SCNG--------SAWKCVCDT----NWGGILCDQDLNFCGTHEPCKHGGTCE 367
             |.....|..|  ||..        .:.:|.|::    .:.|..| ||::.|| .:||.....|.
Zfish   746 -CYDVDECAEGLSSCGAHSHCVNLPGSHRCQCESGFQFGFDGRTC-QDVDECG-EQPCHAQALCS 807

  Fly   368 NTAPDKYRCTCAEGLSGE--QCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMG-- 428
            | :|..:||.|..|..|:  ||    ||      :||       ..:|:.:.:|.|....:.|
Zfish   808 N-SPGSFRCQCQPGYHGDGFQC----HP------QNG-------HPKTRCEQHRDSLQSGDGGVP 854

  Fly   429 ---------------RPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDC 478
                           ||::...|......:...||...|:.:|.    ||        |...||
Zfish   855 AVGAFIPQCDEEGQYRPLQCHGSTGHCWCVDNRGQERAGTRTPP----GS--------PPRNCD- 906

  Fly   479 AAGWTGPT-----CEINIDECAGGPCEHGGTCIDLIGGFRCECPPE--WHGDVCQVDVNECEAPH 536
                 .|.     ||.:.|....   |:||  :.::|.|..:|..|  :....|......|....
Zfish   907 -----EPVRPKTHCEQHRDSLQS---ENGG--VPVVGAFIPQCDEEGQYRPQQCHGSTGHCWCVD 961

  Fly   537 SAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIG-PCINAKECRNQPGSFACICKE 600
            :.|                             ...|.|....| |.:|.    :||......|::
Zfish   962 NRG-----------------------------QERAGTRTPPGSPRVNC----DQPVHLRTRCEQ 993

  Fly   601 -------GWGGV--------TCAENLDDCVGQCR----NGAT----CIDLVNDYRCA-------- 634
                   |.|||        .|.|.     ||.|    :|:|    |:|.....|..
Zfish   994 HRDSLQSGDGGVPAVGAFIPQCDEE-----GQYRPQQCHGSTGHCWCVDNRGQERAGTRTPPGSP 1053

  Fly   635 ---CASGFKGR-DCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPC- 694
               |....:.: .||...|...:.   :||  :.:||.|...|.        ||.:..  |..|
Zfish  1054 RVNCDQPVRPKTHCEQHRDSLQSG---DGG--IPVVGAFIPQCD--------EEGQYR--PQQCH 1103

  Fly   695 -LEGHC------------LNTPEGY-YCHC-PPDRAGKHCEQLR----------PLCSQ--PPCN 732
             ..|||            ..||.|. ..:| .|.|:..||||.|          |:...  |.|:
Zfish  1104 GSTGHCWCVDSRGQERAGTRTPPGSPRVNCDQPVRSKTHCEQHRDSLQSGDGGVPVVGAFIPQCD 1168

  Fly   733 E----------------GCFANVSLATSATTTTTTTTTATTTRKMAKPSGLP------------- 768
            |                .|..|.....:.|.|               |.|.|
Zfish  1169 EEGQYRPQQCHGSTGHCWCVDNRGQERAGTRT---------------PPGSPRVNCDQPVRPKTQ 1218

  Fly   769 CSGH------GSCEMSDVGTF---C---------KCHVGHTG-TFCEHNLNE---------CSP- 804
            |..|      |:..:..||.|   |         :|| |.|| .:|..|..:         .||
Zfish  1219 CEQHRDSLQSGNDGVPVVGAFIPQCDEEGQYRTQQCH-GSTGHCWCVDNRGQERAGTRTPPGSPR 1282

  Fly   805 ----NPCR---------------NGGI---------CLDGDGDFTCECMSGWTGKRCSERATGCY 841
                .|.|               |.|:         | |.:|.:..:...|.||.        |:
Zfish  1283 VNCDQPVRPKTQCEQHRDSLQSGNDGVPVVGAFIPQC-DEEGQYRTQQCHGSTGH--------CW 1338

  Fly   842 A----GQCQNGGTCMPGAP----DKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCESGAG 898
            .    ||.:.|....||:|    |:.::|..:|             :|.|       .:.:||.|
Zfish  1339 CVDNRGQERAGTRTPPGSPRVNCDQPVRPKTQC-------------EQHR-------DSLQSGDG 1383

  Fly   899 WFRCVCAQGFSGPDCRINVNECSPQPCQGG---ATCIDGIG--GYSCICPPGRHGLRCE--ILL- 955
            .   |.|.|...|.|. ...:..||.|.|.   ..|:|..|  ......|||...:.|:  :::
Zfish  1384 G---VPAVGAFIPQCD-EEGQYRPQQCHGSTGHCWCVDSRGQERAGTRTPPGSPRVNCDQPVIVP 1444

  Fly   956 --SDPKSACQN-ASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWCGLPN 1017
              ..|:|.|:. .::.:..|.....||::|.     :.:.....|...|..|:|.|   ||
Zfish  1445 PTQRPESVCERWRASLLQQYGGQPDSQHYLP-----QCDSAGEFNPVQCYGGSSYC---WC---- 1497

  Fly  1018 CYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRR--VAPPRLPAKSSCW 1080
               ||  :....:.|. :.|:...||...| ::||        .:.|..|  |.||  |..:|..
Zfish  1498 ---VD--ANGREVPGT-RSHDAVKPACIPT-VASP--------TVHPLPRPDVTPP--PTGTSLL 1545

  Fly  1081 PNQ----AVVNENCA-----RLTILLALERVGKGASVEGL---CSLVRVL---LAAQLIKKPAST 1130
            ..|    .|:..|..     |.::||||.    |:.|.|:   |...:|.   ||.:.|.:.:..
Zfish  1546 YAQGQQIGVLPLNGTQMDKERSSVLLALH----GSIVVGIDYDCRERKVYWTDLAGRTINRASLD 1606

  Fly  1131 FGQDPGMLMVLCDLKTGTNDTVELTVSSSKLNDPQLPVAVGLLGELLSFRQLNGIQRRKELELQH 1195
            .|.:|.:::                  ::.|..|:     ||                 .:::..
Zfish  1607 PGSEPEIII------------------NTALTSPE-----GL-----------------AVDVAR 1631

  Fly  1196 AKLAALTSIVEVKLETARVADGSGHSLLIGVLCGVFIVLVGFSVFISLYW 1245
            .:|..:.|.:: |:|||.:.....|.|....|.....::|..|.. :|||
Zfish  1632 RRLFWVDSTLD-KIETANLDGSDRHVLFATDLVNPRAMIVDSSTG-TLYW 1679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	19/72 (26%)
		DSL	220..282	CDD:279722	15/92 (16%)
		EGF_CA	350..388	CDD:238011	14/39 (36%)
		EGF_CA	490..526	CDD:238011	8/37 (22%)
		EGF_CA	610..645	CDD:238011	9/54 (17%)
		EGF_CA	647..683	CDD:238011	7/35 (20%)
		EGF_CA	798..833	CDD:238011	13/72 (18%)
		EGF_CA	879..913	CDD:238011	9/33 (27%)
		EGF_CA	916..952	CDD:238011	10/40 (25%)
		VWC_out	<993..1053	CDD:214565	15/59 (25%)
nid2a	XP_005169904.1	NIDO	113..278	CDD:214712
		EGF_3	442..470	CDD:289699
		nidG2	474..697	CDD:238158	45/202 (22%)
		EGF_3	710..746	CDD:289699	13/44 (30%)
		EGF_CA	748..790	CDD:214542	8/42 (19%)
		EGF_3	799..828	CDD:289699	10/29 (34%)
		Thyroglobulin_1	839..905	CDD:278514	13/77 (17%)
		Thyroglobulin_1	915..978	CDD:278514	16/96 (17%)
		Thyroglobulin_1	991..1054	CDD:278514	15/67 (22%)
		Thyroglobulin_1	1067..1130	CDD:278514	19/77 (25%)
		Thyroglobulin_1	1143..1206	CDD:278514	14/77 (18%)
		Thyroglobulin_1	1219..1282	CDD:278514	15/63 (24%)
		Thyroglobulin_1	1295..1358	CDD:278514	14/71 (20%)
		Thyroglobulin_1	1371..1434	CDD:278514	21/86 (24%)
		TY	1453..1518	CDD:238114	17/82 (21%)
		LY	1569..1606	CDD:214531	12/40 (30%)
		LY	1612..1654	CDD:214531	10/82 (12%)
		LY	1655..1699	CDD:214531	8/26 (31%)
		LY	1700..1742	CDD:214531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910