DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and C901

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_572673.1	Gene:	C901 / 32032	FlyBaseID:	FBgn0021742	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	711	Identity:	158/711 - (22%)
Similarity:	217/711 - (30%)	Gaps:	304/711 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 VLSDPGVGAIVLPFTFRWTKSFTLILQALDMYNTSYPDAERLIEETSYSGVILPSPEWKTLDHIG 227
            :|||.....:::      |....|.|:.::.|..:: ||    .::|.|.:    |.||
  Fly     1 MLSDKKAALLLV------TAITALKLEEMNAYRRNF-DA----RQSSNSNI----PLWK------ 44

  Fly   228 RNARITYRVRVQCAVTYYNTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCD 292
                              ...|....:.|  |..||.|..:|...||.||||..|:..:|:.|||
  Fly    45 ------------------QRACEKSQKQR--QNAHYVCDEKGDFKCLPGWQGDLCQVPMCRRGCD 89

  Fly   293 PVHGKCDRPGECECRPGWRGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTH 357
            |::|.|.|||||.||.|:.|.||::|:..|||:||.|. ..::|:|...|.|:.|        |.
  Fly    90 PMNGYCQRPGECRCRIGYSGELCDKCIPLPGCQHGGCT-KPFECICKPGWAGLFC--------TE 145

  Fly   358 EPCKHG-----GTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQV 417
            ..|:.|     |.||  ||.:  |.|..|.:|..|.    .|||.|....|||
  Fly   146 PSCRTGCHSTRGYCE--APGE--CRCRIGYAGRTCS----ECATMPGCQHGTC------------ 190

  Fly   418 YRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGW 482
                      .:|:.                                           |.|..|:
  Fly   191 ----------NKPLE-------------------------------------------CLCLPGY 202

  Fly   483 TGPTCEINI--DECA--GGPCEHGGTCIDLIGGFRCECPPEWHGDVCQ-------VDVNECEAPH 536
            ||..|:..|  .:|:  .|.|...|         .|.|...|.|..|.       ....:||||
  Fly   203 TGLLCQTPICDPDCSKQHGYCRKPG---------ECRCKVGWTGSQCDKCFPYPGCANGDCEAP- 257

  Fly   537 SAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEG 601
                                                                     :.|.|..|
  Fly   258 ---------------------------------------------------------WECNCHPG 265

  Fly   602 WGGVTCAENLDDCV---GQCRNGATCIDLVND---YRCACASGFKGRDCETDIDECATSPC---- 656
            |||:.|.|.|..||   ..|.||..|..|..:   |:|.|..||.|::||...|...||..
  Fly   266 WGGMLCDEKLTYCVEHPDTCENGGKCTSLSREDGSYQCQCRQGFLGKNCEIRDDFLLTSEAPPRI 330

  Fly   657 -----------------RNGGECV------------DMVG------------KFNCICPLGYSGS 680
                             :||.:.:            .:||            |.:.:..:..:|:
  Fly   331 TPPTPAELVLELDGELDQNGQQDIGAGVPDDSEPGGGLVGEKLPAGNEPERRKNDTVANVATAGT 395

  Fly   681 -----------------------LCEEAKEN-------------CTPSPCLEGHCLNTPEGYYCH 709
                                   ..|...:|             .||.|...|.  .|.:|....
  Fly   396 GAGAGPMNSLPGNSNATRTTLVVATETGSDNATNEALSAVTTRRATPIPLTSGE--KTVKGNATS 458

  Fly   710 CPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATT-----TRKMAKPS 765
            ......    .|.||........|...||::.|.:.|.|.||..||||     |....||:
  Fly   459 VSVATG----PQPRPPLPIVASQEQTIANLAPAGTVTVTATTAPTATTAATSVTSHKDKPN 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722	15/61 (25%)
		EGF_CA	350..388	CDD:238011	12/42 (29%)
		EGF_CA	490..526	CDD:238011	9/39 (23%)
		EGF_CA	610..645	CDD:238011	14/40 (35%)
		EGF_CA	647..683	CDD:238011	9/103 (9%)
		EGF_CA	798..833	CDD:238011
		EGF_CA	879..913	CDD:238011
		EGF_CA	916..952	CDD:238011
		VWC_out	<993..1053	CDD:214565
C901	NP_572673.1	DSL	<56..79	CDD:302925	11/22 (50%)
C901	NP_572673.1	EGF_CA	280..315	CDD:238011	11/34 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46730at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24044
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020