DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and Sned1

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_038939693.1	Gene:	Sned1 / 316638	RGDID:	1566079	Length:	1504	Species:	Rattus norvegicus

Alignment Length:	1165	Identity:	297/1165 - (25%)
Similarity:	433/1165 - (37%)	Gaps:	337/1165 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 RPGECECRPGWRGPLCNECMVYPGCKHG-----SC--NGSAWKCVCDTNWGGILCDQDLNFCGTH 357
            |..:.:.|.|..|...:.|:|...|.:|     .|  ...::.|.|...:.|..|..|:|.|.:|
  Rat   254 RIDDAQVRVGGCGHTTSVCLVLRPCLNGGKCIDDCVTGNPSYTCSCLAGFTGRRCHLDVNECASH 318

  Fly   358 EPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSH 422
             ||::||||.: ..:.:.|.|..|..|..||..:.||..:.|:|||.|..::|:.
  Rat   319 -PCQNGGTCTH-GVNSFSCQCPAGFQGPTCESAQSPCDNKVCQNGGQCQAESSSA---------- 371

  Fly   423 GRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTC 487
                                                                .|.|.||:||.||
  Rat   372 ----------------------------------------------------VCVCQAGYTGATC 384

  Fly   488 EINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATA 552
            |.::|||:..||.:||:|:||:|.:.|.|...:.|..|:                      |.:.
  Rat   385 ETDVDECSSDPCLNGGSCVDLVGNYSCICVEPFEGPQCE----------------------TGSY 427

  Fly   553 IIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAEN-LDDCVG 616
            ::.|...|                  .||:|...|.:....:.|.|.||:.|:.|.|. |:||
  Rat   428 VVPSPCLS------------------NPCLNGGTCVDADQGYVCECPEGFMGLDCRERILNDC-- 472

  Fly   617 QCRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCR------NGGECVDMVGKFNCICPL 675
            .||||..|:. .|...|.|..||.|..||.::   ..:||.      :||.|::..|.:.|:|..
  Rat   473 DCRNGGRCLG-ANTTICQCPPGFFGLLCEFEV---TATPCNMNTQCPDGGYCMEYGGSYLCVCHT 533

  Fly   676 GYSGSLCEEAKENCTPSPCLEGHCLN------TPEGYYCHCPPDRAGKHCEQLRP-LCSQPPCNE 733
            .::.|       :..||||....|.|      ..:.|.|.||....|:|||:.|| |||..||..
  Rat   534 DHNIS-------HSLPSPCDSDPCFNGGSCDAHEDSYTCECPRGFHGRHCEKARPHLCSSGPCRN 591

  Fly   734 GCFANVSLATSATTTTTTTTTAT---TTR--KMAKP----SGLPCSGHGSCEMSDVGTF-CKCHV 788
            |       .|...|......|..   |.|  ::.||    || ||...|:| ...:|.: |.|..
  Rat   592 G-------GTCKETGDEYRCTCPYRFTGRHCEIGKPDSCASG-PCHNGGTC-FHYIGKYKCDCPP 647

  Fly   789 GHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGC-------YAGQCQ 846
            |.:|..||...:.|..:||.|||||.|...||:|.|..|:||.|| :....|       :|....
  Rat   648 GFSGRHCEIAPSPCFRSPCMNGGICEDLGTDFSCHCQPGYTGHRC-QAEVDCGQPEEVKHATMRL 711

  Fly   847 NGG--------TCMPGAPDKALQPHCR-CAPGWTGLF-----CAEAIDQCRGQPCHNGGTCESGA 897
            ||.        ||.||.....|. |.| |.|  .|::     |.| :|:|:.|||.:.|:|:...
  Rat   712 NGTRMGSVALYTCDPGFSLSVLS-HMRVCQP--QGVWSQPPQCIE-VDECQSQPCLHKGSCQDLI 772

  Fly   898 GWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICPPGRHGLRCEI--LLSDPKS 960
            ..::|:|:.|:.|..|.:..:||..|||:.|.:|.|..|.:.|.||.|..|..||.  :||....
  Rat   773 AGYQCLCSPGYEGVHCELETDECQAQPCRNGGSCRDLPGAFICQCPEGFVGTHCETGRVLSGGSH 837

  Fly   961 ACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNAC-VCENG------------TSRCT--N 1010
            ..:.|..:.....|         |.|..:...:.|...| ..|.|            |.||.  .
  Rat   838 RTRAAGRSEGKPGA---------ILLLDKPPRERNPQGCGDLEGGRKLGGGSLRAPPTHRCAIPL 893

  Fly  1011 LW-CGLPNCYKVDPLSK---------SSNLSGVCK-----------QH----------EVCV--- 1041
            .| ..|.:.|.|.|||.         ||.....|.           ||          .:||
  Rat   894 SWPLLLASPYPVFPLSSPPSPRVPPCSSGQPFGCSPEVDACASSPCQHGGRCEDGGGAYLCVCPE 958

  Fly  1042 -------PALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSCWPNQAVVNENCARLTI---L 1096
                   ..:|:.|.||||..||.|.|...|.           ||........::|.:..:   .
  Rat   959 GFFGYNCETVSDPCFSSPCGGRGYCLASNGSH-----------SCTCKVGYTGKDCTKELLPPTA 1012

  Fly  1097 LALERVGK-GASV-----EGLCSLVRVLLAAQLIKKPASTFGQDPGMLMVLCDLKTGTNDTVELT 1155
            |.:|||.: |.|:     ||       ..|.|::...|.|:....|        .:...|.|:.:
  Rat  1013 LRVERVEESGVSISWSPPEG-------TTARQVLDGYAVTYASSDG--------SSRRTDFVDRS 1062

  Fly  1156 VSSSKLNDPQLPVAVGLLGELLSFRQLNGIQRRKELELQHAKLAALTSIVEVKLETARVADGSGH 1220
            .||.:|.    .:|.|....:..|........:.::.   ...|.||......:|...|.:.|.:
  Rat  1063 RSSHQLR----ALAAGRAYNISVFSVKRNTNNKNDIS---RPAALLTRTRPRPIEDFEVTNISAN 1120

  Fly  1221 SLLIGVLCGVFIVLVGFSVFISLYWK-QRLAYRTSSGMNLTPSLDALRHEEEKSNNLQNEENLRR 1284
            :                   ||:.|. .|:.:.|.|.:.::    .|..|:....:.:.:.::.|
  Rat  1121 A-------------------ISVQWALHRIQHATVSRVRVS----VLYPEDTVVQSTEVDRSVDR 1162

  Fly  1285 YT--NPLKGSTSSLRAAT-----GMEL---SLNPAP-----------ELAASAASSSALH 1323
            .|  :.|.|...|:|..|     |.|.   ||..||           .|.||..::::.|
  Rat  1163 LTFGDLLPGRRYSVRLTTLSGPGGAEYPTESLASAPLNVWTRPLPPANLTASRVTATSAH 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011	14/37 (38%)
		EGF_CA	490..526	CDD:238011	14/35 (40%)
		EGF_CA	610..645	CDD:238011	14/35 (40%)
		EGF_CA	647..683	CDD:238011	9/41 (22%)
		EGF_CA	798..833	CDD:238011	16/34 (47%)
		EGF_CA	879..913	CDD:238011	11/33 (33%)
		EGF_CA	916..952	CDD:238011	14/35 (40%)
		VWC_out	<993..1053	CDD:214565	25/115 (22%)
Sned1	XP_038939693.1	NIDO	104..260	CDD:214712	1/5 (20%)
		EGF_CA	272..308	CDD:238011	8/35 (23%)
		EGF_CA	311..347	CDD:238011	14/37 (38%)
		EGF_CA	387..423	CDD:238011	14/35 (40%)
		EGF_CA	433..464	CDD:238011	10/48 (21%)
		EGF_CA	545..577	CDD:238011	9/31 (29%)
		EGF_CA	585..616	CDD:238011	9/37 (24%)
		EGF_CA	621..655	CDD:238011	11/35 (31%)
		EGF_CA	<664..693	CDD:238011	17/29 (59%)
		CCP	698..752	CDD:153056	14/56 (25%)
		EGF_CA	754..789	CDD:238011	11/34 (32%)
		EGF_CA	793..827	CDD:238011	14/33 (42%)
		EGF_CA	931..966	CDD:238011	4/34 (12%)
		fn3	1009..1089	CDD:394996	21/98 (21%)
		fn3	1108..1189	CDD:394996	19/103 (18%)
		FN3	1205..1297	CDD:238020	4/18 (22%)
		EGF_CA	1412..1443	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010