DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and Dner

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_017452337.1	Gene:	Dner / 316573	RGDID:	1359385	Length:	746	Species:	Rattus norvegicus

Alignment Length:	684	Identity:	180/684 - (26%)
Similarity:	256/684 - (37%)	Gaps:	191/684 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   358 EPCKHGGTC--------ENTAPDK---YRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSN 411
            :||::||.|        |:.|.|.   |.|||..|:||..|:.|..|||:.||.: |.|:..:|:
  Rat    51 QPCRNGGVCTPRSVTDQEHPAVDAEPGYSCTCPAGVSGTDCQFVADPCASNPCHH-GNCSSSSSS 114

  Fly   412 RTQAQ-----------VYRTSHGRSNMGRPV--------RRSSSMRSL---------DHLRPEGQ 448
            .:.:.           :....:...|..:|:        ..|.:.|.|         |.:.|..|
  Rat   115 SSSSSSSSSSSDSYLCICNDGYEGLNCEQPLPSIPTSGWTESMAPRQLQPVPATQEPDIILPRSQ 179

  Fly   449 ALNGSSSPGLVSLGSLQL------------QQQLAPDFTCDCA-----AGWTGPTCEINIDECAG 496
            |        .|:|.:.|.            |.::.||..|..|     ||  |......:.:...
  Rat   180 A--------TVTLPTWQPKTGQKVVEMKWDQVEVVPDVACGNASSNNSAG--GRLVSFEVPQNTS 234

  Fly   497 GPCEHGGTCIDLI------GGFRCECPPEWHGDVCQVD---VNECEAPHSAGIAANALLTTTATA 552
            .......|.:.::      .||: :|        ..:|   |...:||... :....:||.....
  Rat   235 VKIRQDATALLILLWKVTATGFQ-QC--------SLIDGRSVTPLQAPGGL-VLLEEMLTLGPNH 289

  Fly   553 IIG---SNLSSTALLAALTSAVASTSLAIG-------PCINAKECRNQP--GSFACICKEGWGGV 605
            .||   .:::.:.:...||..|.:::...|       .|....:|..:|  .:|:|.|::.:.|.
  Rat   290 FIGFVNDSVAKSIVALRLTLVVKASTCVPGDGHSNDIECSGKGKCATKPSEATFSCTCEDQYIGT 354

  Fly   606 TCAENLDDCVGQ-CRNGATCIDL-----VNDYRCACASGFKGRDCETDIDECATSPCRNGGECVD 664
            .| |..|.|..: |:|.|:|||.     .:::.|.|..|:.|..|::.||.|...|||||..||.
  Rat   355 FC-EEFDACQRKPCQNEASCIDANEKQDGSNFTCLCLPGYTGELCQSKIDYCVLDPCRNGATCVS 418

  Fly   665 MVGKFNCICPLGYSGSLCEEAKENCTPSPCL-EGHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQ 728
            .:..|.|.|..||.||.|||..:.|..|||. .|.|......:.|.|.|...|..|.||...|:.
  Rat   419 SLSGFTCQCLEGYFGSACEEKVDPCMSSPCQNNGTCYVDGVHFTCSCSPGFTGPTCAQLVDFCAL 483

  Fly   729 PPCNEGCFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHGSCEMSDVGTF--CKCHVGHT 791
            .||                                       .||.|.  .|||.  |.|..|:.
  Rat   484 SPC---------------------------------------AHGMCR--SVGTSYKCLCDPGYH 507

  Fly   792 GTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMPGAP 856
            |.:||...|||...||.|...|.|....:.|.|::.:.|..|.     .|.
  Rat   508 GLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCE-----LYK-------------- 553

  Fly   857 DKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECS 921
                                   |.|....|.|||||:|......|:||.||:|.:|.|::|||.
  Rat   554 -----------------------DPCANISCLNGGTCDSEGLNGTCICAPGFTGEECDIDINECD 595

  Fly   922 PQPCQGGATCIDGIGGYSCICPPGRHGLRCEILL 955
            ..||....||:|...||:|.||.|..|..|||.|
  Rat   596 SNPCHHAGTCLDQPNGYTCHCPHGWVGANCEIHL 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011	15/40 (38%)
		EGF_CA	490..526	CDD:238011	4/41 (10%)
		EGF_CA	610..645	CDD:238011	12/40 (30%)
		EGF_CA	647..683	CDD:238011	17/35 (49%)
		EGF_CA	798..833	CDD:238011	11/34 (32%)
		EGF_CA	879..913	CDD:238011	15/33 (45%)
		EGF_CA	916..952	CDD:238011	15/35 (43%)
		VWC_out	<993..1053	CDD:214565
Dner	XP_017452337.1	EGF_CA	402..437	CDD:238011	17/34 (50%)
		EGF_CA	440..474	CDD:238011	10/33 (30%)
		EGF_CA	516..550	CDD:238011	11/33 (33%)
		EGF_CA	590..626	CDD:238011	15/35 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338547
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930