DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and dlb

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_571033.1	Gene:	dlb / 30141	ZFINID:	ZDB-GENE-980526-114	Length:	615	Species:	Danio rerio

Alignment Length:	742	Identity:	225/742 - (30%)
Similarity:	304/742 - (40%)	Gaps:	209/742 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 NLIALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGCSPCTTAFRLCL 131
            :|..|:.:.|:..::::|.|||::...|.|..     :|       |.|:     .|...||:||
Zfish     5 SLYCLLSVSLLQLVASSGVFELKVHSFSTTRR-----FC-------RRTR-----DCNIFFRICL 52

  Fly   132 KEYQTTEQGASISTGCSFGNATTKIL-GGSSFVLSDPGVGAIVLPFTFRWTKSFTLILQALDMYN 195
            |.   :|...|....|:||...|.:| ...|.:.|.   .||.:||.|:|..:|:||::|   :|
Zfish    53 KH---SEDVISAEPPCTFGTGQTSVLRADQSSIASS---AAIRVPFHFKWPGTFSLIIEA---WN 108

  Fly   196 TSYP--------DAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCTTF 252
            ...|        :...||...:....:....:|....|.|..:.:.|...|.|...|:...|:.:
Zfish   109 AESPKEHHDYTENQNNLISRLATRRRLAVGEDWSQDVHFGDQSELRYSYHVFCDEFYFGEACSDY 173

  Fly   253 CRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLCNE 317
            ||||||..|||.|...|.|.||.||||..|.:.||.:.|...||.|:.||||:||.||:||.|:|
Zfish   174 CRPRDDTLGHYTCDENGNKECLVGWQGDYCSDPICSSDCSERHGYCESPGECKCRLGWQGPSCSE 238

  Fly   318 CMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGL 382
            |:.||||.||:|: ..|:|||...|||:.|:||||:|..|:||.:|.||.||....|.|||..|.
Zfish   239 CVHYPGCLHGTCS-QPWQCVCKEGWGGLFCNQDLNYCTNHKPCANGATCTNTGQGSYTCTCRPGF 302

  Fly   383 SGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEG 447
            .|..||:..:.|...||:|||:|
Zfish   303 GGTNCELEINECDCNPCKNGGSC------------------------------------------ 325

  Fly   448 QALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCID-LIGG 511
                                ..|..|::|.|..|:.|..|||....||..||.:||||.: ..||
Zfish   326 --------------------NDLENDYSCTCPQGFYGKNCEIIAMTCADDPCFNGGTCEEKFTGG 370

  Fly   512 FRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSL 576
            :.|.|||.:.|..|:..::.|.  |.
Zfish   371 YVCRCPPTFTGSNCEKRLDRCS--HK--------------------------------------- 394

  Fly   577 AIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVG-QCRNGATCIDLVNDYRCACASGFK 640
               ||.|..||.:...|..|.|:.|:.|..|..|:|||.. .|:|..||.|.:|||.|.|..||.
Zfish   395 ---PCANGGECVDLGASALCRCRPGFSGSRCETNIDDCARYPCQNAGTCQDGINDYTCTCTLGFT 456

  Fly   641 GRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCE----EAKENCTP-----SP--- 693
            |::|....|.|.|:||.:||.|........|.|..|:.||.||    .:.|...|     ||
Zfish   457 GKNCSLRADACLTNPCLHGGTCFTHFSGPVCQCVPGFMGSTCEFPVQASLEKMAPRVGQTSPSAV 521

  Fly   694 ---CLEG-------------------HCLNTPEGYYC----------------HCPPDRAGKHCE 720
               |:.|                   |.|...:  .|                |.|.||   ...
Zfish   522 AVSCVLGVLAVFLGVCVGLVVLRRRRHRLRRQQ--LCDSVFNDLETVNNLDRQHYPYDR---DFS 581

  Fly   721 QLRPLCSQPPCN-EGCFANVSLATSAT 746
            |::      ||| ||   .:|||.|.|
Zfish   582 QVK------PCNTEG---RISLAASHT 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	22/78 (28%)
		DSL	220..282	CDD:279722	26/61 (43%)
		EGF_CA	350..388	CDD:238011	18/37 (49%)
		EGF_CA	490..526	CDD:238011	15/36 (42%)
		EGF_CA	610..645	CDD:238011	17/35 (49%)
		EGF_CA	647..683	CDD:238011	13/35 (37%)
		EGF_CA	798..833	CDD:238011
		EGF_CA	879..913	CDD:238011
		EGF_CA	916..952	CDD:238011
		VWC_out	<993..1053	CDD:214565
dlb	NP_571033.1	MNNL	21..75	CDD:284966	21/73 (29%)
		DSL	141..203	CDD:279722	26/61 (43%)
		EGF_CA	270..308	CDD:238011	18/37 (49%)
		EGF_CA	311..346	CDD:238011	13/96 (14%)
		EGF_CA	392..423	CDD:238011	11/74 (15%)
		EGF_CA	425..460	CDD:238011	17/34 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578055
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850