DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and dld

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_571030.2	Gene:	dld / 30138	ZFINID:	ZDB-GENE-990415-47	Length:	717	Species:	Danio rerio

Alignment Length:	673	Identity:	221/673 - (32%)
Similarity:	301/673 - (44%)	Gaps:	174/673 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LIALILILLVHKISAAGNFELEILEISNTNSHLLNGYCC-GMPAELRATKTIGCSPCTTAFRLCL 131
            :||::|.:::.:...:|.|||::.|..|......|..|| |..||     .:.|. |.|.||:||
Zfish     5 MIAVLLCVMISQGFCSGVFELKLQEFLNKKGVTGNANCCKGSAAE-----GLQCE-CKTFFRICL 63

  Fly   132 KEYQTTEQGASISTG--CSFGNATTKILGGSSFVL--SDPG---VGAIVLPFTFRWTKSFTLILQ 189
            |.||     |::|..  |::|.|.|.:||.:||.:  |.|.   ...|...|.|.|..:|:||::
Zfish    64 KHYQ-----ANVSPDPPCTYGGAVTPVLGSNSFQVPESFPDSSFTNPIPFAFGFTWPGTFSLIIE 123

  Fly   190 AL-----DMYNTSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTC 249
            ||     |..:|..||  |||...:....:....||.....:|....:.|..|..|...||...|
Zfish   124 ALHTDSTDDLSTENPD--RLISRMTTQRHLTVGEEWSQDLQVGGRTELKYSYRFVCDEHYYGEGC 186

  Fly   250 TTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPL 314
            :.|||||||.|||:.||..|:.:|.:||:|..|.|.||..|||..||.||:||||:||.|:.|..
Zfish   187 SVFCRPRDDTFGHFTCGERGEIICNSGWKGQYCTEPICLPGCDEDHGFCDKPGECKCRVGFSGKY 251

  Fly   315 CNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCA 379
            |::|:.||||.||:|. ..|:|.|...|||:.|:||||:|..|:||::|.||.||
Zfish   252 CDDCIRYPGCLHGTCQ-QPWQCNCQEGWGGLFCNQDLNYCTHHKPCQNGATCTNT---------- 305

  Fly   380 EGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLR 444

Zfish   306 ----------------------------------------------------------------- 305

  Fly   445 PEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLI 509
              ||             ||          :||.|..|:||.:|||.::||:|.||.:||:|.||.
Zfish   306 --GQ-------------GS----------YTCSCRPGFTGDSCEIEVNECSGSPCRNGGSCTDLE 345

  Fly   510 GGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVAST 574
            ..:.|.|||.::|..|::....|
Zfish   346 NTYSCTCPPGFYGRNCELSAMTC------------------------------------------ 368

  Fly   575 SLAIGPCINAKECRNQP-GSFACICKEGWGGVTCAENLDDCVGQ-CRNGATCIDLVNDYRCACAS 637
              |.|||.|..:|.:.| |.:.|.|..|:.|..|.:.:|.|... |.|.|.|:|||:.|.|.|..
Zfish   369 --ADGPCFNGGQCADNPEGGYFCQCPMGYAGFNCEKKIDHCSSNPCSNDAQCLDLVDSYLCQCPE 431

  Fly   638 GFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLEGHCLNT 702
            ||.|..||.:||||||.||:|||.|.|.:..:.|.||.||:|..|..|...|..:||..|...:.
Zfish   432 GFTGTHCEDNIDECATYPCQNGGTCQDGLSDYTCTCPPGYTGKNCTSAVNKCLHNPCHNGATCHE 496

  Fly   703 PEG-YYCHCPPDRAGKHCEQLRP 724
            .:| |.|.|.|...|::|:.|.|
Zfish   497 MDGRYVCACIPGYGGRNCQFLLP 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	30/80 (38%)
		DSL	220..282	CDD:279722	25/61 (41%)
		EGF_CA	350..388	CDD:238011	12/37 (32%)
		EGF_CA	490..526	CDD:238011	15/35 (43%)
		EGF_CA	610..645	CDD:238011	15/35 (43%)
		EGF_CA	647..683	CDD:238011	19/35 (54%)
		EGF_CA	798..833	CDD:238011
		EGF_CA	879..913	CDD:238011
		EGF_CA	916..952	CDD:238011
		VWC_out	<993..1053	CDD:214565
dld	NP_571030.2	MNNL	20..90	CDD:284966	30/80 (38%)
		DSL	157..219	CDD:128366	25/61 (41%)
		EGF_CA	286..324	CDD:238011	22/137 (16%)
		EGF_CA	327..362	CDD:238011	15/34 (44%)
		EGF_CA	<371..401	CDD:238011	11/29 (38%)
		EGF_CA	404..439	CDD:238011	15/34 (44%)
		EGF_CA	441..477	CDD:238011	19/35 (54%)
		EGF_CA	480..515	CDD:238011	10/34 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..693
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578049
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850