DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser and Fbln7

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_215832.6	Gene:	Fbln7 / 296145	RGDID:	1310131	Length:	439	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	106/461 - (22%)
Similarity:	160/461 - (34%)	Gaps:	153/461 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   414 QAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGL------VSLGSLQLQQQLAP 472
            :.|..|.:.|..||  ..|.::...::..:.|:...:   |.|.|      ...||..|... ..
  Rat    45 KGQETRFTEGIRNM--KSRLTALQNTVSKMTPDAPPV---SCPALDAPPNGKKFGSKYLVDH-EV 103

  Fly   473 DFTCD------------CAAG--WTG--PTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWH 521
            .|||:            |.|.  |||  |.|. :..||:..||.:||||::.:..:||.|||...
  Rat   104 HFTCNPGFQLVGPXSVVCLANGTWTGEQPRCR-DTSECSSQPCHNGGTCVEGVHHYRCICPPGKT 167

  Fly   522 GDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKE 586
            |:.||   ::.:|....|:|.::..:                                   .|..
  Rat   168 GNRCQ---HQTQAAAPGGVAGDSAYS-----------------------------------RAPR 194

  Fly   587 CRNQPGSFACICKEGW------GGVTCAENLDDC--VGQ------CRNGATCIDLVNDYRCACAS 637
            |........|.|:.|:      ||.:..:::::|  .||      |.:  .|::....|||.|.|
  Rat   195 CAQVEREQHCSCEAGFHLSGTAGGHSVCQDVNECEIYGQEGRPRLCMH--ACVNTPGSYRCTCPS 257

  Fly   638 GFK----GRDCETDIDECATSP---CRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCL 695
            |::    |:.|| |:|||| .|   |..|..|::..|.|.|:.|      .|.|...|.:.....
  Rat   258 GYRILADGKSCE-DVDECA-GPQHMCPRGTTCINTGGGFQCVNP------ECPEGSGNISYVKTS 314

  Fly   696 EGHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTRK 760
            ...|...|      ||.|  .:.|..|....|        |..:||.::..|..|....||
  Rat   315 PFQCERNP------CPMD--SRPCRHLPKTIS--------FHYLSLPSNLKTPITLFRMAT---- 359

  Fly   761 MAKPSGLPCSGHGSCEMSDVGTFCKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECM 825
                :.:|                    ||.|           ||..|.|.:..:..|.|..:..
  Rat   360 ----ASVP--------------------GHPG-----------PNSLRFGIVGGNSRGHFVMQRS 389

  Fly   826 SGWTGK 831
            ...||:
  Rat   390 DRQTGE 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011
		EGF_CA	490..526	CDD:238011	14/35 (40%)
		EGF_CA	610..645	CDD:238011	12/46 (26%)
		EGF_CA	647..683	CDD:238011	13/38 (34%)
		EGF_CA	798..833	CDD:238011	8/34 (24%)
		EGF_CA	879..913	CDD:238011
		EGF_CA	916..952	CDD:238011
		VWC_out	<993..1053	CDD:214565
Fbln7	XP_215832.6	CCP	81..135	CDD:153056	14/54 (26%)
		EGF_CA	136..172	CDD:238011	14/35 (40%)
		vWFA	<220..267	CDD:412136	12/48 (25%)
		cEGF	250..273	CDD:403760	10/23 (43%)
		EGF_CA	270..307	CDD:311536	15/43 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11395
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000