DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and Pear1

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001128431.1	Gene:	Pear1 / 295293	RGDID:	1305653	Length:	1033	Species:	Rattus norvegicus

Alignment Length:	1025	Identity:	244/1025 - (23%)
Similarity:	311/1025 - (30%)	Gaps:	442/1025 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 SDPGVGAIVLPFTFRWTKSFTLILQALDMYNTSYPDAE---------------RLIEETSYSGVI 214
            :||.|      .|| | :|||...:...:...|.|.||               .::..|.|..|:
  Rat    22 NDPNV------CTF-W-ESFTTTTKESHLRPFSLPPAESCDRPWEDPHTCAQPMVVYRTVYRQVV 78

  Fly   215 LPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQG 279
                            ::..|.|:||...||.::..  |.|
  Rat    79 ----------------KMDSRPRLQCCGGYYESSGA--CVP------------------------ 101

  Fly   280 VNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLC-NECMVYPGCKHGSC-------NGSAWKC 336
                  :|...|  |||:|..|..|:|.|||||..| :||.  ||.....|       |.|:
  Rat   102 ------LCAQEC--VHGRCVAPNRCQCAPGWRGDDCSSECA--PGMWGPQCDRLCLCGNSSS--- 153

  Fly   337 VCDTNWGGILCDQDLNFCGTHEPCK--------------HGGTCENTAPDKYRCTCAEGLSGEQC 387
             ||...|...|...|......:||.              :|.:|:   |....|.|..|.:|..|
  Rat   154 -CDPRSGVCFCPSGLQPPDCLQPCPDGHYGPACQFDCHCYGASCD---PRDGACFCPPGRTGPSC 214

  Fly   388 EIVEHPCA----------TRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDH 442
            .:   ||:          |.||:|||.
  Rat   215 NV---PCSQGTDGFFCPRTYPCQNGGV-------------------------------------- 238

  Fly   443 LRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGP-------CE 500
              |:|            |.||            |.|..||.|..|.:...|...||       |.
  Rat   239 --PQG------------SQGS------------CSCPPGWMGVICSLPCPEGFHGPNCTQECRCH 277

  Fly   501 HGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLA 565
            :||.|....|  :|.|.|.:.||.|:   .||....                 .|.:.:.|
  Rat   278 NGGLCDRFTG--QCHCAPGYIGDRCR---EECPVGR-----------------FGQDCAET---- 316

  Fly   566 ALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGATCIDLVND 630
                           |..|...|..|.:.||:|:.|:.|..|.|.|
  Rat   317 ---------------CDCAPGARCFPANGACLCEHGFTGDRCTERL------------------- 347

  Fly   631 YRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEA---------- 685
                |..|..|..|:   |.|...| .:...|..|.|:  |.|..|::|..|.|:
  Rat   348 ----CPDGRYGLSCQ---DPCTCDP-EHSLSCHPMHGE--CSCQPGWAGLHCNESCPQDTHGAGC 402

  Fly   686 KENCTPSPCLEGH-CLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTT 749
            :|:|.   ||.|. ||  .:...|.|.|...|.||..   ||  ||
  Rat   403 QEHCL---CLHGGVCL--ADSGLCRCAPGYTGPHCAN---LC--PP------------------- 438

  Fly   750 TTTTTATTTRKMAKPSGLPCSGHGSCE----MSDVGTFCKCHVGHTGTFCEHNLNECSPN----- 805
                         ...|:.||.|.|||    .|.|...|.|..|.....|.   ..|.|.
  Rat   439 -------------NTYGINCSSHCSCENAIACSPVDGTCICKEGWQRGNCS---VPCPPGTWGFS 487

  Fly   806 -----PCRNGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQ----------CQNGGTCMPGA 855
                 .|.:.|:|....|  .|.|..||.|..|.   ..|..||          |.:...|.|
  Rat   488 CNASCQCAHEGVCSPQTG--ACTCTPGWRGVHCQ---LPCPKGQFGEGCASVCDCDHSDGCDP-- 545

  Fly   856 PDKALQPHCRCAPGWTGLFC----------AEAIDQCRGQPCHNGGTC--ESGAGWFRCVCAQGF 908
                :..||||..||.|..|          |...:.|   .|.|||||  |:|    .||||.||
  Rat   546 ----VHGHCRCQAGWMGTRCHLPCPEGFWGANCSNAC---TCKNGGTCVPENG----NCVCAPGF 599

  Fly   909 SGPD----------------CRINVNECSPQPCQGGATCIDGIGGYSC--ICPPGRHGLRCEILL 955
            .||.                |:.| |..|..|..|..:|:.|..|..|  .||||..||:|
  Rat   600 RGPSCQRPCPPGRYGKRCVPCKCN-NHSSCHPSDGTCSCLAGWTGPDCSESCPPGHWGLKC---- 659

  Fly   956 SDPKSACQ-NASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWCGLPNCY 1019
            |.|   || :...|..|                   :|    .:|||..|.:.        |||.
  Rat   660 SQP---CQCHHGATCHP-------------------QD----GSCVCIPGRTG--------PNCS 690

  Fly  1020 KVDPLSKSSNLSGV-------CKQHEVCVPALSET--CLSSPCNVRGDCR 1060
            :..|    |.:.||       |...|:|.|   ||  |:..|.:....|:
  Rat   691 EGCP----SRMFGVNCSQLCQCDPGEMCHP---ETGACVCPPGHSGAHCK 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722	8/61 (13%)
		EGF_CA	350..388	CDD:238011	10/51 (20%)
		EGF_CA	490..526	CDD:238011	13/42 (31%)
		EGF_CA	610..645	CDD:238011	4/34 (12%)
		EGF_CA	647..683	CDD:238011	10/35 (29%)
		EGF_CA	798..833	CDD:238011	11/44 (25%)
		EGF_CA	879..913	CDD:238011	17/51 (33%)
		EGF_CA	916..952	CDD:238011	15/37 (41%)
		VWC_out	<993..1053	CDD:214565	18/68 (26%)
Pear1	NP_001128431.1	EMI	25..93	CDD:284877	18/91 (20%)
		EGF_CA	535..580	CDD:304395	13/53 (25%)
		Laminin_EGF	620..665	CDD:278482	20/52 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910