DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ser and Notch2

DIOPT Version :10

Sequence 1:NP_524527.3 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster
Sequence 2:NP_077334.2 Gene:Notch2 / 29492 RGDID:3188 Length:2471 Species:Rattus norvegicus


Alignment Length:976 Identity:287/976 - (29%)
Similarity:390/976 - (39%) Gaps:237/976 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   239 QCAVTYYNTTC------------------------TTFCRP---------RDDQFGHYACGSEGQ 270
            |||..:..|.|                        |..|.|         :.|:.....|.::|:
  Rat   557 QCATGFTGTLCDENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGR 621

  Fly   271 KLCL-NGWQ--------GVNCEEAICKAGCDP-VHGKC----DRPGECECRPGWRGPLC------ 315
            .:.| ||:|        |:|||........:| :||.|    :| ..|.|.||:.|..|      
  Rat   622 CIDLVNGYQCNCQPGTSGLNCEINFDDCASNPCLHGACVDGINR-YSCVCSPGFTGQRCNIDIDE 685

  Fly   316 ------------------------------------NECMVYPGCKHGSCNG--SAWKCVCDTNW 342
                                                |||:..| |.||:|.|  |.:||:||..|
  Rat   686 CASNPCRKGATCINDVNGFRCMCPEGPHHPSCYSQVNECLSSP-CIHGNCTGGLSGYKCLCDAGW 749

  Fly   343 GGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTL 407
            .||.|:.|.|.| ...||::||||.|.. :.|||||.:|..|..|::....||:.||.|.|||..
  Rat   750 VGINCEVDKNEC-LSNPCQNGGTCNNLV-NGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCLD 812

  Fly   408 KTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAP 472
            ..|.       .|.|               ..|.:.....|.:....||......::..:.....
  Rat   813 DVSG-------YTCH---------------CMLPYTGKNCQTVLAPCSPNPCENAAVCKEAPNFE 855

  Fly   473 DFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHS 537
            .|||.||.||.|..|.:::|||...||.:.|.|.:..|.:.|||||.:.|..|:.|:|:|.|   
  Rat   856 SFTCLCAPGWQGQRCTVDVDECVSKPCMNNGICHNTQGSYMCECPPGFSGMDCEEDINDCLA--- 917

  Fly   538 AGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGW 602
                                                     .||.|...|.::..:|:|:|..|:
  Rat   918 -----------------------------------------NPCQNGGSCVDKVNTFSCLCLPGF 941

  Fly   603 GGVTCAENLDDCVGQ-CRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMV 666
            .|..|..::::|:.: |:||.||.|.||.|.|.|.:||.|..||.:||||..|.|.|||.|||.:
  Rat   942 VGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCTCPAGFHGVHCENNIDECTESSCFNGGTCVDGI 1006

  Fly   667 GKFNCICPLGYSGSLCEEAKENCTPSPCL-EGHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPP 730
            ..|:|:||:|::|..|......|:.:||| .|.|::....|.|.||....||:|:.|..|||..|
  Rat  1007 NSFSCLCPVGFTGPFCLHDINECSSNPCLNSGTCVDGLGTYRCTCPLGYTGKNCQTLVNLCSPSP 1071

  Fly   731 C-NEGCFANVS-----LATSATTTTTTTTTATTTRKMAKPSGLP----CSGHGSCEMSDVGTFCK 785
            | |:|..|...     |...............:.:..|...|:|    |...|.|..:.....|:
  Rat  1072 CKNKGTCAQEKARPRCLCPPGWDGAYCDVLNVSCKAAALQKGVPVEHLCQHSGICINAGNTHHCQ 1136

  Fly   786 CHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGT 850
            |.:|:||::||..|:||:.|||::|..|.|..|.:.|||:.|:.|..|......|....||||||
  Rat  1137 CPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGT 1201

  Fly   851 CMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQP-CHNGGTCESGAGWFRCVCAQGFSGPDCR 914
            |:    |......|.|.||..||.|.|.||.|.|.| |.|||.|....|.:.|.|..||:|..|.
  Rat  1202 CI----DLVNHFKCSCPPGTRGLLCEENIDDCAGGPHCLNGGQCVDRIGGYSCRCLPGFAGERCE 1262

  Fly   915 INVNECSPQPC--QGGATCIDGIGGYSCICPPGRHGLRCEILLS-DPKSACQN------ASNT-- 968
            .::|||...||  :|...||.....|.|:|.....|..||..|. .|:..|.|      |||.  
  Rat  1263 GDINECLSNPCSSEGSLDCIQLKNNYQCVCRSAFTGRHCETFLDVCPQKPCLNGGTCAVASNVPD 1327

  Fly   969 -----ISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWCGLPNCYKVDPLSKSS 1028
                 ..|..:..|.|:              :|....|..| .:|.:...| |:|:         
  Rat  1328 GFICRCPPGFSGARCQS--------------SCGQVKCRRG-EQCVHTASG-PHCF--------- 1367

  Fly  1029 NLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSCWPNQAVVNENCARL 1093
                 |...:.|    ...|.|:||...|.|         .|.|.|...||..:......:|...
  Rat  1368 -----CLNRKDC----ESGCASNPCQHGGTC---------YPQRQPPYYSCRCSPPFWGSHCESY 1414

  Fly  1094 T 1094
            |
  Rat  1415 T 1415

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SerNP_524527.3 MNNL 83..238 CDD:462222
DSL 220..282 CDD:128366 16/84 (19%)
EGF_CA 350..388 CDD:238011 17/37 (46%)
EGF_CA 490..526 CDD:238011 14/35 (40%)
EGF_CA 610..645 CDD:238011 15/35 (43%)
EGF_CA 647..683 CDD:238011 18/35 (51%)
EGF_CA 690..720 CDD:238011 11/30 (37%)
EGF_CA 798..833 CDD:238011 15/34 (44%)
EGF_CA 879..913 CDD:238011 16/34 (47%)
EGF_CA 916..952 CDD:238011 12/37 (32%)
VWC_out <993..1053 CDD:214565 11/59 (19%)
Notch2NP_077334.2 EGF_CA 109..143 CDD:238011
EGF_CA 182..218 CDD:238011
EGF_CA 260..296 CDD:238011
EGF_CA 298..335 CDD:238011
EGF_CA 415..454 CDD:238011
EGF_CA 456..492 CDD:238011
EGF_CA 495..530 CDD:238011
EGF_CA 532..567 CDD:238011 4/9 (44%)
EGF_CA 570..604 CDD:238011 3/33 (9%)
EGF_CA 608..643 CDD:238011 9/34 (26%)
EGF_CA 645..679 CDD:238011 10/34 (29%)
EGF_CA 682..717 CDD:238011 0/34 (0%)
EGF_CA 757..793 CDD:238011 17/37 (46%)
EGF_CA 795..831 CDD:238011 12/57 (21%)
EGF_CA 873..909 CDD:238011 14/35 (40%)
EGF_CA 911..947 CDD:238011 13/79 (16%)
EGF_CA 949..985 CDD:238011 15/35 (43%)
EGF_CA 987..1022 CDD:238011 18/34 (53%)
EGF_CA 1025..1061 CDD:238011 12/35 (34%)
EGF_CA 1117..1147 CDD:238011 8/29 (28%)
EGF_CA 1151..1185 CDD:238011 14/33 (42%)
EGF_CA 1188..1223 CDD:238011 15/38 (39%)
EGF_CA 1225..1262 CDD:238011 16/36 (44%)
EGF_CA 1264..1302 CDD:238011 12/37 (32%)
EGF_CA <1312..1343 CDD:238011 7/30 (23%)
Notch 1423..1456 CDD:459658
Negative regulatory region (NRR). /evidence=ECO:0000250 1425..1677
Notch 1463..1497 CDD:459658
Notch 1501..1534 CDD:459658
NOD 1539..1594 CDD:462014
NODP 1618..1673 CDD:462229
JMTM_Notch2 1659..1740 CDD:411986
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1751..1788
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1794..1813
ANK repeat 1827..1874 CDD:293786
ANK 1 1827..1871
ANKYR <1851..2066 CDD:440430
ANK 2 1876..1905
ANK repeat 1877..1907 CDD:293786
ANK 3 1909..1939
ANK repeat 1943..1974 CDD:293786
ANK 4 1943..1972
ANK repeat 1976..2007 CDD:293786
ANK 5 1976..2005
ANK repeat 2009..2040 CDD:293786
ANK 6 2009..2038
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2097..2116
Atrophin-1 2105..>2422 CDD:460830
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2380..2471
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.