| Sequence 1: | NP_001287558.1 | Gene: | Ser / 43275 | FlyBaseID: | FBgn0004197 | Length: | 1407 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_077334.2 | Gene: | Notch2 / 29492 | RGDID: | 3188 | Length: | 2471 | Species: | Rattus norvegicus |
| Alignment Length: | 976 | Identity: | 287/976 - (29%) |
|---|---|---|---|
| Similarity: | 390/976 - (39%) | Gaps: | 237/976 - (24%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 239 QCAVTYYNTTC------------------------TTFCRP---------RDDQFGHYACGSEGQ 270
Fly 271 KLCL-NGWQ--------GVNCEEAICKAGCDP-VHGKC----DRPGECECRPGWRGPLC------ 315
Fly 316 ------------------------------------NECMVYPGCKHGSCNG--SAWKCVCDTNW 342
Fly 343 GGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTL 407
Fly 408 KTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAP 472
Fly 473 DFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHS 537
Fly 538 AGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGW 602
Fly 603 GGVTCAENLDDCVGQ-CRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMV 666
Fly 667 GKFNCICPLGYSGSLCEEAKENCTPSPCL-EGHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPP 730
Fly 731 C-NEGCFANVS-----LATSATTTTTTTTTATTTRKMAKPSGLP----CSGHGSCEMSDVGTFCK 785
Fly 786 CHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGT 850
Fly 851 CMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQP-CHNGGTCESGAGWFRCVCAQGFSGPDCR 914
Fly 915 INVNECSPQPC--QGGATCIDGIGGYSCICPPGRHGLRCEILLS-DPKSACQN------ASNT-- 968
Fly 969 -----ISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWCGLPNCYKVDPLSKSS 1028
Fly 1029 NLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSCWPNQAVVNENCARL 1093
Fly 1094 T 1094 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Ser | NP_001287558.1 | MNNL | 83..161 | CDD:284966 | |
| DSL | 220..282 | CDD:279722 | 16/84 (19%) | ||
| EGF_CA | 350..388 | CDD:238011 | 17/37 (46%) | ||
| EGF_CA | 490..526 | CDD:238011 | 14/35 (40%) | ||
| EGF_CA | 610..645 | CDD:238011 | 15/35 (43%) | ||
| EGF_CA | 647..683 | CDD:238011 | 18/35 (51%) | ||
| EGF_CA | 798..833 | CDD:238011 | 15/34 (44%) | ||
| EGF_CA | 879..913 | CDD:238011 | 16/34 (47%) | ||
| EGF_CA | 916..952 | CDD:238011 | 12/37 (32%) | ||
| VWC_out | <993..1053 | CDD:214565 | 11/59 (19%) | ||
| Notch2 | NP_077334.2 | EGF_CA | 109..143 | CDD:238011 | |
| EGF_CA | 182..218 | CDD:238011 | |||
| EGF_CA | 260..296 | CDD:238011 | |||
| EGF_CA | 298..335 | CDD:238011 | |||
| EGF_CA | 415..454 | CDD:238011 | |||
| EGF_CA | 456..492 | CDD:238011 | |||
| EGF_CA | 495..530 | CDD:238011 | |||
| EGF_CA | 532..567 | CDD:238011 | 4/9 (44%) | ||
| EGF_CA | 570..604 | CDD:238011 | 3/33 (9%) | ||
| EGF_CA | 608..643 | CDD:238011 | 9/34 (26%) | ||
| EGF_CA | 645..679 | CDD:238011 | 10/34 (29%) | ||
| EGF_CA | 682..717 | CDD:238011 | 0/34 (0%) | ||
| EGF_CA | 757..793 | CDD:238011 | 17/37 (46%) | ||
| EGF_CA | 795..831 | CDD:238011 | 12/57 (21%) | ||
| EGF_CA | 873..909 | CDD:238011 | 14/35 (40%) | ||
| EGF_CA | 911..947 | CDD:238011 | 13/79 (16%) | ||
| EGF_CA | 949..985 | CDD:238011 | 15/35 (43%) | ||
| EGF_CA | 987..1022 | CDD:238011 | 18/34 (53%) | ||
| EGF_CA | 1025..1061 | CDD:238011 | 12/35 (34%) | ||
| EGF_CA | 1117..1147 | CDD:238011 | 8/29 (28%) | ||
| EGF_CA | 1151..1185 | CDD:238011 | 14/33 (42%) | ||
| EGF_CA | 1188..1223 | CDD:238011 | 15/38 (39%) | ||
| EGF_CA | 1225..1262 | CDD:238011 | 16/36 (44%) | ||
| EGF_CA | 1264..1302 | CDD:238011 | 12/37 (32%) | ||
| EGF_CA | <1312..1343 | CDD:238011 | 7/30 (23%) | ||
| Notch | 1423..1456 | CDD:278494 | |||
| Negative regulatory region (NRR). /evidence=ECO:0000250 | 1425..1677 | ||||
| Notch | 1463..1497 | CDD:278494 | |||
| Notch | 1501..1534 | CDD:278494 | |||
| NOD | 1540..1591 | CDD:284282 | |||
| NODP | 1619..1673 | CDD:284987 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1751..1788 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1794..1813 | ||||
| Ank_2 | <1820..1907 | CDD:289560 | |||
| ANK repeat | 1827..1874 | CDD:293786 | |||
| ANK 1 | 1827..1871 | ||||
| ANK | 1872..1997 | CDD:238125 | |||
| ANK 2 | 1876..1905 | ||||
| ANK repeat | 1877..1907 | CDD:293786 | |||
| Ank_2 | 1881..1974 | CDD:289560 | |||
| ANK 3 | 1909..1939 | ||||
| ANK | 1938..2062 | CDD:238125 | |||
| ANK repeat | 1943..1974 | CDD:293786 | |||
| ANK 4 | 1943..1972 | ||||
| Ank_2 | 1948..2040 | CDD:289560 | |||
| ANK repeat | 1976..2007 | CDD:293786 | |||
| ANK 5 | 1976..2005 | ||||
| ANK repeat | 2009..2040 | CDD:293786 | |||
| ANK 6 | 2009..2038 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2097..2116 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2380..2471 | ||||
| DUF3454 | 2381..2439 | CDD:288764 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 50 | 1.000 | Domainoid score | I11395 |
| eggNOG | 1 | 0.900 | - | - | E33208_3BAFT | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.810 | |||||