DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and Jag1

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_062020.2	Gene:	Jag1 / 29146	RGDID:	2937	Length:	1219	Species:	Rattus norvegicus

Alignment Length:	1416	Identity:	477/1416 - (33%)
Similarity:	660/1416 - (46%)	Gaps:	345/1416 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LIALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCG---MPAELRATKTIGCSPCTTAFRL 129
            |:||:..|......|:|.||||||.:.|.|..|.||.|||   .|.:.:.|:    ..|.|.|::
  Rat    17 LLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTR----DECDTYFKV 77

  Fly   130 CLKEYQTTEQGASISTG--CSFGNATTKILGGSSFVL-----SDPGVGAIVLPFTFRWTKSFTLI 187
            ||||||     :.::.|  ||||:.:|.::||::|.|     :|.  ..|||||:|.|.:|:||:
  Rat    78 CLKEYQ-----SRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDR--NRIVLPFSFAWPRSYTLL 135

  Fly   188 LQALDMYN-TSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCTT 251
            ::|.|..| |..||:  :||:.|:||:|.||.:|:||......|...|::||.|...||...|..
  Rat   136 VEAWDSSNDTIQPDS--IIEKASHSGMINPSRQWQTLKQNTGIAHFEYQIRVTCDDHYYGFGCNK 198

  Fly   252 FCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLCN 316
            |||||||.||||||...|.|.|:.||.|..|.:|||:.||.|.||.|..||:|.|:.||:|..|:
  Rat   199 FCRPRDDFFGHYACDQNGNKTCMEGWMGPECNKAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCD 263

  Fly   317 ECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEG 381
            :|:.:|||.||:|| ..|:|:|:|||||.|||:|||:||||:||.:.|||.||.||||:|:|.||
  Rat   264 KCIPHPGCVHGTCN-EPWQCLCETNWGGQLCDKDLNYCGTHQPCLNRGTCSNTGPDKYQCSCPEG 327

  Fly   382 LSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPE 446
            .||..|||.||.|.:.||.|.|:|.            .||.|
  Rat   328 YSGPNCEIAEHACLSDPCHNRGSCK------------ETSSG----------------------- 357

  Fly   447 GQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGG 511
                                       |.|:|:.|||||||..|||:|:...|.|||||.||:.|
  Rat   358 ---------------------------FECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNG 395

  Fly   512 FRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSL 576
            |:|.|||:|.|..||:|.|||||.
  Rat   396 FKCVCPPQWTGKTCQLDANECEAK----------------------------------------- 419

  Fly   577 AIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGATCIDLVNDYRCACASGFKG 641
               ||:||:.|:|...|:.|.|..||.|..|..|::||:|||:|.|:|.||||.|||.|..|:.|
  Rat   420 ---PCVNARSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAG 481

  Fly   642 RDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLEG-HCLNTPEG 705
            ..||.||||||::||.|||.|.:.:.:|.|:||.|:||:||:...:.|.|:||..| .|.|....
  Rat   482 DHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASD 546

  Fly   706 YYCHCPPDRAGKHCEQLRPLCSQPPCN--EGCFANVSLATSATTTTTTTTTATTTRKMAKPSGL- 767
            |:|.||.|..||:|..|:..|...||.  :.|  .|::|::.|                 |.|:
  Rat   547 YFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSC--TVAMASNDT-----------------PEGVR 592

  Fly   768 -----PCSGHGSCEMSDVGTF-CKCHVGHTGTFCEHNLNECSPNPCRNGGICLDG---------D 817
                 .|..||.|:....|.| |.|:.|.|||:|..|:|:|..|||.|||.|:||         |
  Rat   593 YISSNVCGPHGKCKSESGGKFTCDCNKGFTGTYCHENINDCEGNPCTNGGTCIDGVNSYKCICSD 657

  Fly   818 G-----------------------------DFTCECMSGWTGKRCSERATGCYAGQCQNGGTC-- 851
            |                             ||.|:|.:||.||.|..|.:.|....|.|||||
  Rat   658 GWEGAHCENNINDCSQNPCHYGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYD 722

  Fly   852 --------MPG---------APDKALQPH----------------CRCAPGWTGLFCAEAIDQCR 883
                    .||         |.:.:..|:                |.|..||.|..|.:..:.|.
  Rat   723 EVDTFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGDSFTCVCKEGWEGPICTQNTNDCS 787

  Fly   884 GQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICPPGRHG 948
            ..||:|.|||..|..|:||.||.||:|||||||:|||...||..||||:|.|.||.||||||..|
  Rat   788 PHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYQCICPPGHSG 852

  Fly   949 LRCEILLSDPKSACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWC 1013
            .:|               :.:|..:.:...:    :.|.|...||: ||.|.|.||...|:.:||
  Rat   853 AKC---------------HEVSGRSCITMGR----VILDGAKWDDD-CNTCQCLNGRVACSKVWC 897

  Fly  1014 GLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSS 1078
            |...|    .|.|.   .|.|...:.|:|.|.:.|...||...|:||:....        |.|:.
  Rat   898 GPRPC----QLHKG---HGECPNGQSCIPVLDDQCFVRPCTGAGECRSSSLQ--------PVKTK 947

  Fly  1079 CWPNQAVVNENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGMLMVLCD 1143
            | .:.:...:|||.:|.....|.:..|.:.|.:||.:|.|   .::|..::.:.     :.:.|:
  Rat   948 C-TSDSYYQDNCANITFTFNKEMMSPGLTTEHICSELRNL---NILKNVSAEYS-----IYIACE 1003

  Fly  1144 LKTGTNDTVELTVSSSKLNDPQLPV--AVGLLGELLSFRQLNGIQRRKELELQHAKLAALTSIVE 1206
            .....|:.:.:.:|:..:.|...||  ....:.:|:|.|..|.              :.:.::.|
  Rat  1004 PSLSANNEIHVAISAEDIRDDGNPVKEITDKIIDLVSKRDGNS--------------SLIAAVAE 1054

  Fly  1207 VKLETARVADGSGHSLLIGVLCGVFIVLVGFSVFISLYWKQRLAYR-TSSGMNLTPSLDALRHEE 1270
            |:::...:.:.:  ..|:.:|..|..|.....:..:.||..|...| .||..:..|       |:
  Rat  1055 VRVQRRPLKNRT--DFLVPLLSSVLTVAWVCCLVTAFYWCVRKRRRKPSSHTHSAP-------ED 1110

  Fly  1271 EKSNNLQNEENLRRYTNPLKGSTSSLRAATGMELSLNPAP----ELAASAASSSALHRS------ 1325
            ..:||::  |.|.:..||::            :...|..|    |...|..|....|.|
  Rat  1111 NTTNNVR--EQLNQIKNPIE------------KHGANTVPIKDYENKNSKMSKIRTHNSEVEEDD 1161

  Fly  1326 ------------QPLFPPCDFERELDSSTGLKQAHKRSSQILLHKTQNSDM 1364
                        ||::...|.|.:..|.|..|..:      ..:|..|.|:
  Rat  1162 MDKHQQKVRFAKQPVYTLVDREEKAPSGTPTKHPN------WTNKQDNRDL 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	34/82 (41%)
		DSL	220..282	CDD:279722	30/61 (49%)
		EGF_CA	350..388	CDD:238011	24/37 (65%)
		EGF_CA	490..526	CDD:238011	20/35 (57%)
		EGF_CA	610..645	CDD:238011	19/34 (56%)
		EGF_CA	647..683	CDD:238011	20/35 (57%)
		EGF_CA	798..833	CDD:238011	22/72 (31%)
		EGF_CA	879..913	CDD:238011	17/33 (52%)
		EGF_CA	916..952	CDD:238011	21/35 (60%)
		VWC_out	<993..1053	CDD:214565	20/59 (34%)
Jag1	NP_062020.2	MNNL	32..107	CDD:400141	34/83 (41%)
		DSL	167..229	CDD:396134	30/61 (49%)
		Important for interaction with NOTCH1. /evidence=ECO:0000250	199..207		7/7 (100%)
		EGF_CA	296..334	CDD:238011	24/37 (65%)
		EGF	340..370	CDD:394967	16/91 (18%)
		EGF_CA	374..410	CDD:238011	20/35 (57%)
		EGF_CA	412..447	CDD:238011	18/78 (23%)
		EGF_CA	450..485	CDD:238011	19/34 (56%)
		EGF_CA	487..523	CDD:238011	20/35 (57%)
		EGF_CA	525..560	CDD:238011	14/34 (41%)
		EGF_CA	629..665	CDD:238011	14/35 (40%)
		EGF_CA	667..702	CDD:238011	8/34 (24%)
		EGF_CA	<714..740	CDD:238011	8/25 (32%)
		EGF	748..777	CDD:394967	5/28 (18%)
		EGF_CA	782..817	CDD:238011	17/34 (50%)
		EGF_CA	820..855	CDD:238011	21/34 (62%)
		VWC_out	863..930	CDD:214565	23/78 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1182..1219		7/31 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338548
Domainoid	1	1.000	123	1.000	Domainoid score	I5452
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H180
Inparanoid	1	1.050	688	1.000	Inparanoid score	I665
OMA	1	1.010	-	-		QHG45993
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	1	1.000	-	-		FOG0003067
OrthoInspector	1	1.000	-	-		otm44375
orthoMCL	1	0.900	-	-		OOG6_105778
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2046
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.670