DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ser and CRB2

DIOPT Version :9

Sequence 1:NP_001287558.1 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster
Sequence 2:NP_775960.4 Gene:CRB2 / 286204 HGNCID:18688 Length:1285 Species:Homo sapiens


Alignment Length:1414 Identity:304/1414 - (21%)
Similarity:403/1414 - (28%) Gaps:655/1414 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly   289 AGCDPVHGKCDRPGEC---ECRPGWRGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILC-DQ 349
            ||..|    .:.|..|   .|.||      .||..                   |..||..| ..
Human    31 AGTVP----SEPPSACASDPCAPG------TECQA-------------------TESGGYTCGPM 66

  Fly   350 DLNFCGTHEPCKHGGTCENTAPDK--YRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNR 412
            :...|.| :||.||..|....||.  :||.|..|..|.:||:....||:|||.:|.||       
Human    67 EPRGCAT-QPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATC------- 123

  Fly   413 TQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCD 477
                                                                   :.||..:.|.
Human   124 -------------------------------------------------------RNLADRYECH 133

  Fly   478 CAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEA-PHSAGIA 541
            |..|:.|.|||:.:||||..||.|||:|:|.:|.|||.|.|.:.|..||:|::||:: |.:.|..
Human   134 CPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGT 198

  Fly   542 ANALLT-----TTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEG 601
            .:.|:.     ...|...|::.....|           ..|..||.:...|....|||.|:|..|
Human   199 CHDLVNGFRCDCAGTGYEGTHCEREVL-----------ECASAPCEHNASCLEGLGSFRCLCWPG 252

  Fly   602 WGGVTCAENLDDCVGQ-CRNGATCIDLVN---------------------DYRCACASGFKGRDC 644
            :.|..|..:.|:|... |::|..|:...:                     .:.|.|..||:|.||
Human   253 YSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADC 317

  Fly   645 ETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLE-GHCLNTPEGYYC 708
            ..::||||:.||.|||.|.|:...|.|.||.||:|..|||..:.|...|||. |.|.:|..||.|
Human   318 GVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYIC 382

  Fly   709 HCPPDRAGKHCE-QLR-------PL----------------CSQPPCNEGCF------------- 736
            .||....|:.|. ||.       ||                |..||...|.|             
Human   383 RCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQNTTFSVMAGS 447

  Fly   737 ---ANV-------------------SLAT-------------SATTTTTTTTTATTTRKMAKP-- 764
               |:|                   :|||             :||...|..:.:||...:..|  
Human   448 PIQASVPAGGPLGLALRFRTTLPAGTLATRNDTKESLELALVAATLQATLWSYSTTVLVLRLPDL 512

  Fly   765 -------------------------SGLPC---------------------SGHGSCEMSDVGTF 783
                                     .|.|.                     :|..|.::.| .||
Human   513 ALNDGHWHQVEVVLHLATLELRLWHEGCPARLCVASGPVALASTASATPLPAGISSAQLGD-ATF 576

  Fly   784 CKCHV-----GH------------TGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGK 831
            ..|..     ||            .|  ||.. .:|.|.||.:||.|:|....|.|:|.....|.
Human   577 AGCLQDVRVDGHLLLPEDLGENVLLG--CERR-EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGP 638

  Fly   832 RCSERATGC----------------------------------------YAGQCQNGGTC----- 851
            .|::.....                                        :|.....|.|.     
Human   639 TCADEIPAATFGLGGAPSSASFLLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAGLTVFLSEG 703

  Fly   852 -----MPGAPDKALQPHCRCAPG---------------------------------------WTG 872
                 :||:|...|       ||                                       |.|
Human   704 RIRAEVPGSPAVVL-------PGRWDDGLRHLVMLSFGPDQLQDLGQHVHVGGRLLAADSQPWGG 761

  Fly   873 LF--CAEAI--------------------------------------DQCRGQPCHNGGTCESGA 897
            .|  |.:.:                                      |.|...||.|||||....
Human   762 PFRGCLQDLRLDGCHLPFFPLPLDNSSQPSELGGRQSWNLTAGCVSEDMCSPDPCFNGGTCLVTW 826

  Fly   898 GWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCIC-------PP----------- 944
            ..|.|.|...|:||.|...: .|..|||...|||.:...|:.|:.       ||           
Human   827 NDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVCVAEATFREGPPAAFSGHNASSG 890

  Fly   945 --------------------------------------------GRHGLRCEIL-LSDPKSACQN 964
                                                        |.|||...:| :..|:.| ..
Human   891 RLLGGLSLAFRTRDSEAWLLRAAAGALEGVWLAVRNGSLAGGVRGGHGLPGAVLPIPGPRVA-DG 954

  Fly   965 ASNTI-----SPYTALNRSQNWLD-----IALTGRTED--------------DENCNAC------ 999
            |.:.:     .|....:|...|||     :||.|...|              .||...|      
Human   955 AWHRVRLAMERPAATTSRWLLWLDGAATPVALRGLASDLGFLQGPGAVRILLAENFTGCLGRVAL 1019

  Fly  1000 ---------------------------------------VC------ENGTSR---------CTN 1010
                                                   ||      .:|..|         |..
Human  1020 GGLPLPLARPRPGAAPGAREHFASWPGTPAPILGCRGAPVCAPSPCLHDGACRDLFDAFACACGP 1084

  Fly  1011 LWCGLPNC-YKVDPLSKSSNLSGVCKQHE------VCVP----------------ALSETCL-SS 1051
            .|.| |.| ..|||...:....|.|..|.      .|.|                :|:.||| .|
Human  1085 GWEG-PRCEAHVDPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGS 1148

  Fly  1052 PC---NVRGDCRALE--PSRRVAPPRLPAKSSCWPNQAVVNENCARLTILLALERVGKGASVEGL 1111
            ||   :...:|..||  ..:|...|.||    |..|..:....|          |...|.| |.:
Human  1149 PCEGGSPAANCSCLEGLAGQRCQVPTLP----CEANPCLNGGTC----------RAAGGVS-ECI 1198

  Fly  1112 CSLVRVLLAAQLIKKPASTFGQDPGMLMVLCDLKTGTNDTVELTVSSSKLNDPQLPVAV------ 1170
            |:              |...||       .|::..|.         ...|..|.|.|||      
Human  1199 CN--------------ARFSGQ-------FCEVAKGL---------PLPLPFPLLEVAVPAACAC 1233

  Fly  1171 ------GLLGELLSF---RQLNGIQRRKELELQHAKLAALTSIVEVKLE 1210
                  |||..:|:.   ||..|.....:.|:..|:| .:.|:::|..|
Human  1234 LLLLLLGLLSGILAARKRRQSEGTYSPSQQEVAGARL-EMDSVLKVPPE 1281

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SerNP_001287558.1 MNNL 83..161 CDD:284966
DSL 220..282 CDD:279722
EGF_CA 350..388 CDD:238011 14/39 (36%)
EGF_CA 490..526 CDD:238011 18/35 (51%)
EGF_CA 610..645 CDD:238011 11/56 (20%)
EGF_CA 647..683 CDD:238011 18/35 (51%)
EGF_CA 798..833 CDD:238011 12/34 (35%)
EGF_CA 879..913 CDD:238011 15/71 (21%)
EGF_CA 916..952 CDD:238011 15/97 (15%)
VWC_out <993..1053 CDD:214565 25/143 (17%)
CRB2NP_775960.4 Required for maximum inhibition of APP amyloid-beta peptide secretion. /evidence=ECO:0000269|PubMed:20299451 1..350 115/421 (27%)
EGF_CA 108..144 CDD:238011 15/97 (15%)
EGF_CA 147..182 CDD:238011 18/34 (53%)
EGF_CA 184..221 CDD:238011 8/36 (22%)
EGF_CA 226..259 CDD:238011 11/32 (34%)
EGF_CA 321..356 CDD:238011 18/34 (53%)
EGF_CA 358..393 CDD:238011 13/34 (38%)
Laminin_G_2 465..588 CDD:280389 17/123 (14%)
LamG 653..773 CDD:238058 13/126 (10%)
EGF_CA 812..842 CDD:238011 13/29 (45%)
LamG 900..1024 CDD:304605 20/124 (16%)
EGF 1060..1090 CDD:278437 6/30 (20%)
Interaction with EPB41L5. /evidence=ECO:0000269|PubMed:17920587 1249..1285 9/34 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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