Sequence 1: | NP_001287558.1 | Gene: | Ser / 43275 | FlyBaseID: | FBgn0004197 | Length: | 1407 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_775960.4 | Gene: | CRB2 / 286204 | HGNCID: | 18688 | Length: | 1285 | Species: | Homo sapiens |
Alignment Length: | 1414 | Identity: | 304/1414 - (21%) |
---|---|---|---|
Similarity: | 403/1414 - (28%) | Gaps: | 655/1414 - (46%) |
- Green bases have known domain annotations that are detailed below.
Fly 289 AGCDPVHGKCDRPGEC---ECRPGWRGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILC-DQ 349
Fly 350 DLNFCGTHEPCKHGGTCENTAPDK--YRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNR 412
Fly 413 TQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCD 477
Fly 478 CAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEA-PHSAGIA 541
Fly 542 ANALLT-----TTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEG 601
Fly 602 WGGVTCAENLDDCVGQ-CRNGATCIDLVN---------------------DYRCACASGFKGRDC 644
Fly 645 ETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLE-GHCLNTPEGYYC 708
Fly 709 HCPPDRAGKHCE-QLR-------PL----------------CSQPPCNEGCF------------- 736
Fly 737 ---ANV-------------------SLAT-------------SATTTTTTTTTATTTRKMAKP-- 764
Fly 765 -------------------------SGLPC---------------------SGHGSCEMSDVGTF 783
Fly 784 CKCHV-----GH------------TGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGK 831
Fly 832 RCSERATGC----------------------------------------YAGQCQNGGTC----- 851
Fly 852 -----MPGAPDKALQPHCRCAPG---------------------------------------WTG 872
Fly 873 LF--CAEAI--------------------------------------DQCRGQPCHNGGTCESGA 897
Fly 898 GWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCIC-------PP----------- 944
Fly 945 --------------------------------------------GRHGLRCEIL-LSDPKSACQN 964
Fly 965 ASNTI-----SPYTALNRSQNWLD-----IALTGRTED--------------DENCNAC------ 999
Fly 1000 ---------------------------------------VC------ENGTSR---------CTN 1010
Fly 1011 LWCGLPNC-YKVDPLSKSSNLSGVCKQHE------VCVP----------------ALSETCL-SS 1051
Fly 1052 PC---NVRGDCRALE--PSRRVAPPRLPAKSSCWPNQAVVNENCARLTILLALERVGKGASVEGL 1111
Fly 1112 CSLVRVLLAAQLIKKPASTFGQDPGMLMVLCDLKTGTNDTVELTVSSSKLNDPQLPVAV------ 1170
Fly 1171 ------GLLGELLSF---RQLNGIQRRKELELQHAKLAALTSIVEVKLE 1210 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
Ser | NP_001287558.1 | MNNL | 83..161 | CDD:284966 | |
DSL | 220..282 | CDD:279722 | |||
EGF_CA | 350..388 | CDD:238011 | 14/39 (36%) | ||
EGF_CA | 490..526 | CDD:238011 | 18/35 (51%) | ||
EGF_CA | 610..645 | CDD:238011 | 11/56 (20%) | ||
EGF_CA | 647..683 | CDD:238011 | 18/35 (51%) | ||
EGF_CA | 798..833 | CDD:238011 | 12/34 (35%) | ||
EGF_CA | 879..913 | CDD:238011 | 15/71 (21%) | ||
EGF_CA | 916..952 | CDD:238011 | 15/97 (15%) | ||
VWC_out | <993..1053 | CDD:214565 | 25/143 (17%) | ||
CRB2 | NP_775960.4 | Required for maximum inhibition of APP amyloid-beta peptide secretion. /evidence=ECO:0000269|PubMed:20299451 | 1..350 | 115/421 (27%) | |
EGF_CA | 108..144 | CDD:238011 | 15/97 (15%) | ||
EGF_CA | 147..182 | CDD:238011 | 18/34 (53%) | ||
EGF_CA | 184..221 | CDD:238011 | 8/36 (22%) | ||
EGF_CA | 226..259 | CDD:238011 | 11/32 (34%) | ||
EGF_CA | 321..356 | CDD:238011 | 18/34 (53%) | ||
EGF_CA | 358..393 | CDD:238011 | 13/34 (38%) | ||
Laminin_G_2 | 465..588 | CDD:280389 | 17/123 (14%) | ||
LamG | 653..773 | CDD:238058 | 13/126 (10%) | ||
EGF_CA | 812..842 | CDD:238011 | 13/29 (45%) | ||
LamG | 900..1024 | CDD:304605 | 20/124 (16%) | ||
EGF | 1060..1090 | CDD:278437 | 6/30 (20%) | ||
Interaction with EPB41L5. /evidence=ECO:0000269|PubMed:17920587 | 1249..1285 | 9/34 (26%) | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E33208_3BAFT | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
2 | 1.810 |