DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser and F9

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_113728.1	Gene:	F9 / 24946	RGDID:	2589	Length:	462	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	95/502 - (18%)
Similarity:	139/502 - (27%)	Gaps:	244/502 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly   600 EGW----GGVTCAENLDDCVGQCRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGG 660
            |.|    .|..|..|      .|.||..|.|.:|.|.|.|.:||:||:||.|    ||...:||
  Rat    79 EFWKQYVDGDQCESN------PCLNGGICKDDINSYECWCQAGFEGRNCELD----ATCSIKNG- 132

  Fly   661 ECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLEGHCLNTPEGYYCHCPPDRAGKHCEQLRPL 725
                     .|       ...|:.:.:|.....|.||:.|...:            |.||...|.
  Rat   133 ---------RC-------KQFCKNSPDNKIICSCTEGYQLAEDQ------------KSCEPAVPF 169

  Fly   726 CSQPPCN--------------EGCFANVSLATSATTTTTTTTTATT--------------TR--- 759
                ||.              |..|:|.....|........|.:|.              ||
  Rat   170 ----PCGRVSVAYNSKKITRAETVFSNTDYGNSTELILDDITNSTILDNLTENSEPINDFTRVVG 230

  Fly   760 -KMAKPSGLP----CSGHGSCEMSDVGTFCKCHVGH-----TGTFC------------EHNLNEC 802
             :.|||..:|    .:|       ::..||...:.:     |...|            |||::|.
  Rat   231 GENAKPGQIPWQVILNG-------EIEAFCGGAIINEKWIVTAAHCLKPGDKIEVVAGEHNIDEK 288

  Fly   803 SPNPCRNG-------------------------------------GICLDGDGDFT-------CE 823
            .....|..                                     .||: .:.::|       ..
  Rat   289 EDTEQRRNVIRTIPHHQYNATINKYSHDIALLELDKPLILNSYVTPICV-ANKEYTNIFLKFGSG 352

  Fly   824 CMSGW-----TGKRCS----------ERATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGL 873
            .:|||     .|::.|          :||            ||:.......          :..:
  Rat   353 YVSGWGKVFNKGRQASILQYLRVPLVDRA------------TCLRSTKFSI----------YNNM 395

  Fly   874 FCAEAIDQCRGQPCHNGG--TCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIG 936
            |||         ....||  :||..:|           ||    :|.|..      |.:.:.||.
  Rat   396 FCA---------GYREGGKDSCEGDSG-----------GP----HVTEVE------GTSFLTGII 430

  Fly   937 GYSCICP-PGRHGLRCEILLSDPKSACQNASNTISPYTALNRSQNWL 982
            .:...|. .|::|:                      ||.::|..||:
  Rat   431 SWGEECAMKGKYGI----------------------YTKVSRYVNWI 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011
		EGF_CA	490..526	CDD:238011
		EGF_CA	610..645	CDD:238011	14/34 (41%)
		EGF_CA	647..683	CDD:238011	6/35 (17%)
		EGF_CA	798..833	CDD:238011	10/83 (12%)
		EGF_CA	879..913	CDD:238011	7/35 (20%)
		EGF_CA	916..952	CDD:238011	8/36 (22%)
		VWC_out	<993..1053	CDD:214565
F9	NP_113728.1	GLA	21..85	CDD:214503	2/5 (40%)
		EGF_CA	86..122	CDD:238011	16/41 (39%)
		FXa_inhibition	127..163	CDD:291342	10/64 (16%)
		Tryp_SPc	227..455	CDD:214473	49/309 (16%)
		Tryp_SPc	228..458	CDD:238113	49/310 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910