DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and Crb2

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001157038.1	Gene:	Crb2 / 241324	MGIID:	2679260	Length:	1282	Species:	Mus musculus

Alignment Length:	1372	Identity:	314/1372 - (22%)
Similarity:	409/1372 - (29%)	Gaps:	594/1372 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 DRPGECECRPGWRGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCD-QDLNFCGTHEPCKH 362
            :.|..|...|               |..|:      ||.. |..||..|: .:|..|.| :||.|
Mouse    41 ETPSVCASDP---------------CAPGT------KCQA-TESGGYTCEPSELGGCAT-QPCHH 82

  Fly   363 GGTCENTAPD--KYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRS 425
            |..|....||  .:||.|..|..|..||:....||:|||::||||
Mouse    83 GALCVPQGPDPNSFRCYCVPGFQGPHCELDIDECASRPCQHGGTC-------------------- 127

  Fly   426 NMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEIN 490
                                                      |.||..:.|.|..|:.|.|||..
Mouse   128 ------------------------------------------QNLADHYECHCPLGYAGVTCEAE 150

  Fly   491 IDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEA-PHSAGIAANALLT-----TT 549
            :|||:..||.|||:|:|.:|.:||.|.|.:.|..||:||:||:: |.:.|...:.|:.     ..
Mouse   151 VDECSSAPCLHGGSCLDGVGSYRCVCAPGYAGANCQLDVDECQSQPCAHGGVCHDLVNGFRCDCA 215

  Fly   550 ATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDC 614
            .|...|:......|           ..|..||.:...|.:...||.|:|..|:.|..|..:.|:|
Mouse   216 DTGYEGARCEQEVL-----------ECASAPCAHNASCLDGFRSFRCLCWPGFSGERCEVDEDEC 269

  Fly   615 V-GQCRNGATCIDLVN---------------------DYRCACASGFKGRDCETDIDECATSPCR 657
            . |.|:||..|:...:                     .:.|:|..||.|.||..|:||||:.||.
Mouse   270 ASGPCQNGGQCLQRSDPTLYGGVQAIFPGAFSFSHAAGFLCSCPLGFAGNDCSMDVDECASGPCL 334

  Fly   658 NGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLE-GHCLNTPEGYYCHCPPDRAGKHCE- 720
            |||.|.|:...|.|.|..||:|..|:|..:.|...|||. |.|.:|..||.|.||....|..|.
Mouse   335 NGGSCQDLPNGFQCYCQDGYTGLTCQEDMDECQSEPCLHGGTCSDTVAGYICQCPEAWGGHDCSV 399

  Fly   721 QLR-------PL----------------CSQPPCNEGCF----------------------ANVS 740
            ||.       ||                |..||...|.|                      |::.
Mouse   400 QLTGCQGHTCPLAATCIPTFKSGLHGYFCRCPPGTYGPFCGQNTTFSVVSGSSVWGLVPAAASLG 464

  Fly   741 LATSATTTTTTTTTAT--TTRK------------------------MAKPSGLPCSGH------- 772
            ||....||....|.||  .||.                        :..|......||
Mouse   465 LALRFRTTLLAGTLATLKDTRDSLELVLVGAVLQATLSRHGTAVLILTLPDLALNDGHWHQVEVT 529

  Fly   773 ---GSCEM-----------------------SDV--------------GTFCKCH-----VGH-- 790
               |:.|:                       :.|              |.|..|.     .||
Mouse   530 LHLGTLELRLWHEGCPGQLCVASGPVATGPTASVASGPPGSYSIYLGGGVFAGCFQDVRVEGHLL 594

  Fly   791 -----TGTF---CEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSER----------A 837
                 .||.   ||.. ..|.|.||.:||.|:|....|.|:|...:.|..|::.          |
Mouse   595 LPEELKGTVLLGCERR-EPCQPLPCAHGGACVDLWTHFRCDCPRPYRGATCTDEVPAATFGLGGA 658

  Fly   838 TGCYA------------------------------------------GQCQNGG-----TCMPGA 855
            |...:                                          ||.:..|     ..:||.
Mouse   659 TSSASFLLHQLGPNLTVSFFLRTREPAGLLLQFANDSVASLTVFLSEGQIRAEGLGHPAVVLPGR 723

  Fly   856 PDKALQPHC---------------------RCAPG----WTGLF--CAEAI-------------- 879
            .|..| ||.                     |..|.    |.|.|  |.:.:
Mouse   724 WDDGL-PHLVMLSFGPDQLQDLGQRLYVGGRFYPDDTQLWGGPFRGCLQDLQLNSIHLPFFSSPM 787

  Fly   880 ------------------------DQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNEC 920
                                    |.|...||.|||||......|.|.|::.|:||.| .....|
Mouse   788 ENSSWPSELEAGQSSNLTQGCVSEDTCNPNPCFNGGTCHVTWNDFYCTCSENFTGPTC-AQQRWC 851

  Fly   921 SPQPCQGGATCIDGIGGYSCIC-------PP----GRH------GLRCEILLSDPKSACQNASNT 968
            ..|||...|||.:...|:.|:.       ||    |.:      ||.......|.::....|.:.
Mouse   852 PRQPCLPPATCEEVPDGFVCVAEATFREGPPAVFTGHNVSSSLSGLTLAFRTRDSEAGLLRAVSA 916

  Fly   969 IS--------------------------------------------PYTALNRSQNWLD-----I 984
            ..                                            |..|.:|...|||     :
Mouse   917 AGAHSNIWLAVRNGSLAGDVAGSVLPAPGPRVADGAWHRVRLAREFPQAAASRWLLWLDGAATPV 981

  Fly   985 ALTGRTED--------------DENCNACV--------------CENGT-------------SRC 1008
            ||.|...|              .||...|:              ..:||             |..
Mouse   982 ALHGLGGDLGFLQGPGAVPLLLAENFTGCLGRVALGDFPLPLAPPRSGTVSGAREHFVAWPGSPA 1046

  Fly  1009 TNLWC-GLPNCYKVDPLSKSSNLSG----------VCKQHEVCVPA--------LSETCLSSPCN 1054
            .:|.| |.|.|      |.|..|.|          .|.    |.||        .::.|.|:||
Mouse  1047 VSLGCRGGPVC------SPSPCLHGGACRDLFDAFACS----CGPAWEGPRCEIRADPCRSTPC- 1100

  Fly  1055 VRGDCRALEPSRRV---APP-------RLPAKSSCWPNQAVVNENCARLTILLALERVGKGASVE 1109
            |||.|.| .|..|.   .||       |||.    .|....:|..|.            .||..|
Mouse  1101 VRGQCHA-RPDGRFECRCPPGFSGPRCRLPV----LPQGCNLNSTCK------------DGAPCE 1148

  Fly  1110 G-----LCSLVRVL--LAAQLIKKPASTFGQDPGMLMVLCDLKTGTNDTVELTVSSS-------- 1159
            |     .||....|  |..|.:.||...   .|.:....|.:.:|   ..|.|.|:.
Mouse  1149 GGPLGTNCSCQEGLAGLRCQSLDKPCEA---SPCLNGGTCRVASG---IFECTCSAGFSGQFCEV 1207

  Fly  1160 ------KLNDPQLPVAV------------GLLGELLSF---RQLNGIQRRKELELQHAKLAALTS 1203
                  .|..|.|.|||            |||..:|:.   ||..|.....:.|:..|:| .:.|
Mouse  1208 VKTLPLPLPFPLLEVAVPAACACLLLLLLGLLSGILAARKRRQSEGTYSPSQQEVAGARL-EMDS 1271

  Fly  1204 IVEVKLE 1210
            :::|..|
Mouse  1272 VLKVPPE 1278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011	15/39 (38%)
		EGF_CA	490..526	CDD:238011	16/35 (46%)
		EGF_CA	610..645	CDD:238011	13/56 (23%)
		EGF_CA	647..683	CDD:238011	18/35 (51%)
		EGF_CA	798..833	CDD:238011	12/34 (35%)
		EGF_CA	879..913	CDD:238011	15/71 (21%)
		EGF_CA	916..952	CDD:238011	14/52 (27%)
		VWC_out	<993..1053	CDD:214565	21/105 (20%)
Crb2	NP_001157038.1	EGF_CA	<79..110	CDD:238011	12/30 (40%)
		EGF_CA	112..148	CDD:238011	17/97 (18%)
		EGF_CA	151..186	CDD:238011	16/34 (47%)
		EGF_CA	188..225	CDD:238011	9/36 (25%)
		EGF_CA	230..263	CDD:238011	10/32 (31%)
		EGF_CA	324..360	CDD:238011	18/35 (51%)
		EGF_CA	362..397	CDD:238011	13/34 (38%)
		Laminin_G_2	469..592	CDD:280389	16/122 (13%)
		EGF	613..643	CDD:278437	12/29 (41%)
		LamG	666..776	CDD:238058	15/110 (14%)
		EGF	814..844	CDD:278437	13/29 (45%)
		Laminin_G_2	901..1018	CDD:280389	15/116 (13%)
		EGF_CA	1058..1089	CDD:238011	8/34 (24%)
		EGF_CA	1175..1206	CDD:238011	6/36 (17%)
		Interaction with EPB41L5. /evidence=ECO:0000250\|UniProtKB:Q5IJ48	1246..1282		9/34 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900