DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ser and CRB1

DIOPT Version :10

Sequence 1:NP_524527.3 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster
Sequence 2:XP_016856341.1 Gene:CRB1 / 23418 HGNCID:2343 Length:1451 Species:Homo sapiens


Alignment Length:1141 Identity:270/1141 - (23%)
Similarity:379/1141 - (33%) Gaps:445/1141 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   314 LCNECMVYPGCKHGSCNGSAWKCVCDTNWGGI--LCDQDLNFCGTHEPCKHGGTCENTAPDK-YR 375
            |.|.|.....||..|.:..   |.|......:  .||...:.|.:: ||:...||.||..:: :.
Human    35 LSNSCQNNSTCKDFSKDND---CSCSDTANNLDKDCDNMKDPCFSN-PCQGSATCVNTPGERSFL 95

  Fly   376 CTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSL 440
            |.|..|.||..||.....|....|::||.|       .|..:|           ||         
Human    96 CKCPPGYSGTICETTIGSCGKNSCQHGGIC-------HQDPIY-----------PV--------- 133

  Fly   441 DHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTC 505
                                               |.|.||:.|..|||:.||||..||::|..|
Human   134 -----------------------------------CICPAGYAGRFCEIDHDECASSPCQNGAVC 163

  Fly   506 IDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSA 570
            .|.|.|:.|.|.|.:.|..|.::|:||                                      
Human   164 QDGIDGYSCFCVPGYQGRHCDLEVDEC-------------------------------------- 190

  Fly   571 VASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQ-CRNGATCIDLVNDYRCA 634
                  |..||.|...|.|:.|.:.|||...:.||.|...:|:|..| |.|||||.|.:..|.|.
Human   191 ------ASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCD 249

  Fly   635 CASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLEGHC 699
            ||.||.|..||.:.||||:.||.:||.|||...:::|                |||.|       
Human   250 CAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSC----------------NCTGS------- 291

  Fly   700 LNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTRKMAKP 764
                 |:        .|.|||.|.|||...||:                                
Human   292 -----GF--------TGTHCETLMPLCWSKPCH-------------------------------- 311

  Fly   765 SGLPCSGHGSCEMSDVGTFCKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWT 829
                  .:.:||.|.....|.|..|:||..||.:||||:.|||::.|.|::...:.....::|..
Human   312 ------NNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLP 370

  Fly   830 GKRCSERATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCE 894
            .......|:| |.                     |.|.||:||:.|.|.:::|...||.||||||
Human   371 SSFSYHEASG-YV---------------------CICQPGFTGIHCEEDVNECSSNPCQNGGTCE 413

  Fly   895 SGAGWFRCVC------AQGFSGPDCRINVNECSPQPCQGGATCI----DGIGGYSCICPPGRHGL 949
            :..|.:.|.|      ...:.|.||...:..|:.|.|....|||    ||..|:||:||.|..|.
Human   414 NLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGS 478

  Fly   950 RCEIL-----------------LSDPKSACQNA--SNTISPYTAL----NR-------------- 977
            .|||.                 ::...|.|..|  ..|:.|...|    ||              
Human   479 LCEIATTLSFEGDGFLWVKSGSVTTKGSVCNIALRFQTVQPMALLLFRSNRDVFVKLELLSGYIH 543

  Fly   978 ------SQNWLDIALTGRTED-------------------DENC-NACVC------ENGTSRC-- 1008
                  :|:.:.:.::..|.|                   |::| ..|:.      |:..|.|  
Human   544 LSIQVNNQSKVLLFISHNTSDGEWHFVEVIFAEAVTLTLIDDSCKEKCIAKAPTPLESDQSICAF 608

  Fly  1009 -TNLWCGLP-----------NCY---------------KVD-------PLSKSSNL---SGVCKQ 1036
             .:...|||           |.|               |:|       .:|..|:|   :|    
Human   609 QNSFLGGLPVGMTSNGVALLNFYNMPSTPSFVGCLQDIKIDWNHITLENISSGSSLNVKAG---- 669

  Fly  1037 HEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSCWPNQAVVNENCARLTILLALER 1101
               ||  ..:.|.|.||..||.|..|..|.:           |..::.....||.|..:      
Human   670 ---CV--RKDWCESQPCQSRGRCINLWLSYQ-----------CDCHRPYEGPNCLREYV------ 712

  Fly  1102 VGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGMLMVLCDLKTGTNDTVELTVSSSKLNDPQL 1166
                                      |..||||.....|:..|.....||:.|::....|....|
Human   713 --------------------------AGRFGQDDSTGYVIFTLDESYGDTISLSMFVRTLQPSGL 751

  Fly  1167 PVAVGLLGELLSFRQLNGIQRRKELELQHAKLAALTS-----IVEVKLETARVADGSGHSLLIGV 1226
            .:|:.           |...:...:.|:..:||.||.     :|:..|.     ||:.|      
Human   752 LLALE-----------NSTYQYIRVWLERGRLAMLTPNSPKLVVKFVLN-----DGNVH------ 794

  Fly  1227 LCGVFIVLVGFSV---FISLYW-KQRLAYRTSSGMNLTPS----LDALRHEEEKSNN-------L 1276
                   |:...:   .|.||. .|.|.:.::|...:...    :..|..::|...|       :
Human   795 -------LISLKIKPYKIELYQSSQNLGFISASTWKIEKGDVIYIGGLPDKQETELNGGFFKGCI 852

  Fly  1277 Q----NEENLRRYTNPLKGSTSSLRAATGMELSLNP 1308
            |    |.:||..:.||...:            ||||
Human   853 QDVRLNNQNLEFFPNPTNNA------------SLNP 876

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SerNP_524527.3 MNNL 83..238 CDD:462222
DSL 220..282 CDD:128366
EGF_CA 350..388 CDD:238011 12/38 (32%)
EGF_CA 490..526 CDD:238011 15/35 (43%)
EGF_CA 610..645 CDD:238011 17/35 (49%)
EGF_CA 647..683 CDD:238011 12/35 (34%)
EGF_CA 690..720 CDD:238011 5/29 (17%)
EGF_CA 798..833 CDD:238011 10/34 (29%)
EGF_CA 879..913 CDD:238011 13/39 (33%)
EGF_CA 916..952 CDD:238011 15/39 (38%)
VWC_out <993..1053 CDD:214565 21/105 (20%)
CRB1XP_016856341.1 EGF_CA 72..108 CDD:238011 12/36 (33%)
EGF_CA 148..183 CDD:238011 15/34 (44%)
EGF_CA 187..222 CDD:238011 15/78 (19%)
EGF_CA 225..260 CDD:238011 17/34 (50%)
EGF_CA 262..299 CDD:238011 19/72 (26%)
EGF_CA <309..337 CDD:238011 10/65 (15%)
EGF_CA 339..395 CDD:238011 19/77 (25%)
EGF_CA 397..438 CDD:214542 13/40 (33%)
Laminin_G_2 514..649 CDD:460494 20/134 (15%)
EGF_CA 676..707 CDD:238011 10/41 (24%)
Laminin_G_2 743..860 CDD:460494 26/145 (18%)
EGF_CA <939..968 CDD:238011
Laminin_G_2 1025..1150 CDD:460494
EGF_CA <1191..1220 CDD:238011
EGF_CA 1222..1257 CDD:238011
EGF_CA 1259..1294 CDD:238011
EGF_CA 1342..1378 CDD:238011
Blue background indicates that the domain is not in the aligned region.

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