DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ser and FBN2

DIOPT Version :9

Sequence 1:NP_001287558.1 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster
Sequence 2:NP_001990.2 Gene:FBN2 / 2201 HGNCID:3604 Length:2912 Species:Homo sapiens


Alignment Length:1342 Identity:331/1342 - (24%)
Similarity:457/1342 - (34%) Gaps:492/1342 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 SLKSACNLIALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGC---SP 122
            |||..|.|                |.:....|: |.|...|...||.         |:|.   ||
Human   893 SLKGTCWL----------------NIQDSRCEV-NINGATLKSECCA---------TLGAAWGSP 931

  Fly   123 CTTAFRLCLKEYQTTEQGASISTGCSFGNATTKILGGSSFVLSD----PGVGAIVLPFTFRWTKS 183
            |               :...:.|.|..|.|  :|.|.:...:::    |||              
Human   932 C---------------ERCELDTACPRGLA--RIKGVTCEDVNECEVFPGV-------------- 965

  Fly   184 FTLILQALDMYNTSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRV-QCAVTYYNT 247
                          .|:...:..:.|:.   ...||..|||..|   |:...:|: ||.:.:...
Human   966 --------------CPNGRCVNSKGSFH---CECPEGLTLDGTG---RVCLDIRMEQCYLKWDED 1010

  Fly   248 TCTTFCRPRDDQFGHYACGSEGQKLCLNG--WQGVNCEEAICKAGCDPVHGKCDRPG----ECEC 306
            .|   ..|...:|...||      .|..|  | |..|||             |.:||    |..|
Human  1011 EC---IHPVPGKFRMDAC------CCAVGAAW-GTECEE-------------CPKPGTKEYETLC 1052

  Fly   307 RPGW----RGPL---------CNECMVYPG-CKHGSCNGS--AWKCVCDTNWGGILCDQDLNFCG 355
            ..|.    ||.:         .|||..:|| |.:|.|..:  ::||.|::   |...|.:...|.
Human  1053 PRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNS---GFALDMEERNCT 1114

  Fly   356 THEPCK------HGGTCENTAPDKYRCTCAEGL-SG----EQCEIVEHPCATRP--CRNGGTCTL 407
            ..:.|:      ..|.|.|| |..:.|.|.||. ||    :.|..::. |...|  || |||| :
Human  1115 DIDECRISPDLCGSGICVNT-PGSFECECFEGYESGFMMMKNCMDIDE-CERNPLLCR-GGTC-V 1175

  Fly   408 KTSNRTQAQV---YRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALN------GSSSPGLVSLGS 463
            .|....|...   :..|..|.:.......|.|    |:|...|:.:|      .|.:||      
Human  1176 NTEGSFQCDCPLGHELSPSREDCVDINECSLS----DNLCRNGKCVNMIGTYQCSCNPG------ 1230

  Fly   464 LQLQQQLAPD---------------------------FTCDCAAGWT----GPTCEINIDECAGG 497
                .|..||                           :.|.|:.|:.    |.:| .:||||...
Human  1231 ----YQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC-ADIDECENN 1290

  Fly   498 P--CEHGGTCIDLIGGFRCECPPEWHGDVCQ------VDVNECEAPHSAGIAANALLTTTATAII 554
            |  |: ||.|.::.|.:||.|   :.|.:..      :|||||:.  ::.|........|..:.|
Human  1291 PDICD-GGQCTNIPGEYRCLC---YDGFMASMDMKTCIDVNECDL--NSNICMFGECENTKGSFI 1349

  Fly   555 GSNLSSTALLAALTSAVASTSLAIGP--CINAKECRNQPGSFACICKEGW--GGVTCAENLDDC- 614
            .......::....|.........||.  |.....|.|.||||.|.|:|||  .|:.|.: ||:| 
Human  1350 CHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCID-LDECS 1413

  Fly   615 --VGQCRNGATCIDLVNDYRCACASGFKGR--DCETDIDECA--TSPCRNG-------------- 659
              ..||...|.|::....|||||:.||.|.  .| :|:||||  .:.|.||              
Human  1414 NGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTC-SDVDECAENINLCENGQCLNVPGAYRCECE 1477

  Fly   660 --------------------------GECVDMVGKFNCICPLGY----SGSLCEEAKENCTPSPC 694
                                      |.|.::.|.|:|||..||    :|..|.:..|...|..|
Human  1478 MGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINC 1542

  Fly   695 LEGHCLNTPEGYYCHCPPDRAGKHCEQLRPL-----------C---------SQPPCN------- 732
            :.|.|:|||..|.|:||||      .||.|.           |         ....||       
Human  1543 VNGLCVNTPGRYECNCPPD------FQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGV 1601

  Fly   733 --EGCFANVSLATSATTTTTTTTTATTTRKMAKPSG--------------------LP--CSGHG 773
              ..|..::..|......|.....:|....:. |.|                    ||  |.| |
Human  1602 SRSSCCCSLGKAWGNPCETCPPVNSTEYYTLC-PGGEGFRPNPITIILEDIDECQELPGLCQG-G 1664

  Fly   774 SCEMSDVGTF-CKCHVGH----TGTFCEHNLNECSPNPCRNG-GICLDGDGDFTCEC------MS 826
            :| ::..|:| |:|..|:    ....|| :::||..:|...| |.|.:..|::||.|      ::
Human  1665 NC-INTFGSFQCECPQGYYLSEDTRICE-DIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVN 1727

  Fly   827 GWTGKRCSE-RATGCYAGQCQNGGTCMPGAPDKALQPHCRCA----------------------- 867
            |  |..|.: |.:.||  :..||.||....|....:..|.|.                       
Human  1728 G--GHNCMDMRKSFCY--RSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFK 1788

  Fly   868 ------PGWT-GLFCAEA--IDQCRGQP--CHNGGTCESGAGWFRCVCAQGFSGPDCRI---NVN 918
                  ||:| .:...:|  ||:|:..|  |.| |.|.:..|.|||.|..|||..|..:   :::
Human  1789 TICGNIPGFTFDIHTGKAVDIDECKEIPGICAN-GVCINQIGSFRCECPTGFSYNDLLLVCEDID 1852

  Fly   919 ECS--PQPCQGGATCIDGIGGYSCICPPG----------------------RHGLRCEILLSDPK 959
            |||  ...||..|.||:..|.|.|.|..|                      .||| |..|....:
Human  1853 ECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGL-CVDLQGSYQ 1916

  Fly   960 SACQN--------------------------ASNTISPYTA-------LNRSQNWLDIALTGRTE 991
            ..|.|                          ..||:..|..       |..:.:.|||       
Human  1917 CICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDI------- 1974

  Fly   992 DDENCNAC---VCENGTSRCTN----LWCGLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCL 1049
              :.|::.   ||.||  ||.|    ..|.....|::.|..|:      |.....|| ||..:| 
Human  1975 --DECSSFFGQVCRNG--RCFNEIGSFKCLCNEGYELTPDGKN------CIDTNECV-ALPGSC- 2027

  Fly  1050 SSPCNVRGDCRALEPS-RRVAPPRLPAKSSCWPNQAVVNENC 1090
             ||    |.|:.||.| |.:.||....||          |||
Human  2028 -SP----GTCQNLEGSFRCICPPGYEVKS----------ENC 2054

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SerNP_001287558.1 MNNL 83..161 CDD:284966 18/80 (23%)
DSL 220..282 CDD:279722 17/64 (27%)
EGF_CA 350..388 CDD:238011 13/48 (27%)
EGF_CA 490..526 CDD:238011 14/37 (38%)
EGF_CA 610..645 CDD:238011 15/39 (38%)
EGF_CA 647..683 CDD:238011 18/81 (22%)
EGF_CA 798..833 CDD:238011 12/41 (29%)
EGF_CA 879..913 CDD:238011 16/35 (46%)
EGF_CA 916..952 CDD:238011 16/59 (27%)
VWC_out <993..1053 CDD:214565 19/66 (29%)
FBN2NP_001990.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..52
Interaction with MFAP4. /evidence=ECO:0000269|PubMed:26601954 149..359
TB 225..258 CDD:279073
EGF_CA 276..>306 CDD:214542
EGF_CA 318..358 CDD:284955
TB 375..412 CDD:279073
EGF_CA 535..565 CDD:214542
EGF_CA 575..616 CDD:214542
EGF_CA 617..649 CDD:238011
cEGF 638..661 CDD:289433
EGF_CA 658..698 CDD:214542
TB 715..751 CDD:279073
cEGF 790..813 CDD:289433
EGF_CA 810..845 CDD:238011
TB 907..>935 CDD:279073 11/52 (21%)
TB 1012..1047 CDD:279073 15/57 (26%)
EGF_CA 1115..1149 CDD:214542 10/34 (29%)
EGF_CA 1158..1190 CDD:214542 10/34 (29%)
EGF_CA 1200..1232 CDD:214542 9/45 (20%)
cEGF 1223..1245 CDD:289433 6/31 (19%)
FXa_inhibition 1246..1281 CDD:291342 4/34 (12%)
Plasmod_Pvs28 1293..1446 CDD:283826 49/159 (31%)
EGF_3 1371..1406 CDD:289699 15/34 (44%)
EGF_3 1412..1447 CDD:289699 13/34 (38%)
EGF_CA 1532..1563 CDD:214542 14/36 (39%)
TB 1593..1628 CDD:279073 5/34 (15%)
EGF_CA 1650..1683 CDD:238011 11/34 (32%)
cEGF 1672..1695 CDD:289433 6/23 (26%)
Interaction with MFAP4. /evidence=ECO:0000269|PubMed:26601954 1735..2171 91/358 (25%)
TB 1749..1786 CDD:279073 4/36 (11%)
EGF_CA 1808..1840 CDD:214542 14/32 (44%)
vWFA <1847..1888 CDD:294047 13/40 (33%)
vWFA <1887..1929 CDD:294047 7/42 (17%)
EGF_CA 1934..1968 CDD:214542 4/33 (12%)
EGF_CA 1973..2015 CDD:214542 14/58 (24%)
EGF_CA 2056..2096 CDD:214542
TB 2113..2150 CDD:279073
EGF_CA 2171..2212 CDD:214542
EGF_CA 2213..2252 CDD:214542
vWFA <2251..2290 CDD:294047
TB 2397..2432 CDD:279073
EGF_CA 2449..2490 CDD:214542
vWFA <2489..2529 CDD:294047
vWFA <2527..2563 CDD:294047
EGF_CA 2614..>2643 CDD:214542
Cadherin_repeat <2826..>2873 CDD:206637
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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