DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser and Y70G10A.2

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_499266.2	Gene:	Y70G10A.2 / 190572	WormBaseID:	WBGene00013498	Length:	1489	Species:	Caenorhabditis elegans

Alignment Length:	763	Identity:	144/763 - (18%)
Similarity:	235/763 - (30%)	Gaps:	228/763 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ATSSSLEST--IESADSLGMSKKTA---TKRQRPRHRVPKIAT--LPSTIRDCRSLKSACNLIAL 71
            ||.||.:||  ..|:.|.|.|.:|:   |:....:....|::|  .|.|.:...|.|::.:...|
Worm   357 ATDSSSKSTGSTSSSGSSGTSGRTSSSVTETSTTKQTTIKVSTKVSPQTSQRSSSDKTSISPSTL 421

  Fly    72 ------ILILLVHKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGCSPCTTAFRLC 130
                  ..|:.|..:|.|.:      ..|.:.|..|:.:    .:..|||.:|..|  ||.
Worm   422 TGSTSSTTIIPVTDLSTAQS------SSSTSASTKLSSF----SSTQRATHSISSS--TTG---- 470

  Fly   131 LKEYQTTEQGASISTGCSFGNATTKILGGSSFVLSDPGVGAIVLPFTFRWTKSFTLILQALDMYN 195
            :.|..:.....|.||..|...:|:.:.|...|...|....:...|.|.:.|:|............
Worm   471 ITETSSETSETSKSTTRSSKPSTSGLPGYEIFPPDDVFTRSSEPPGTTKTTESTMTTTAETSGDT 535

  Fly   196 TSYPDAERLIEET-----------------SYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVT 243
            |::...|.....|                 |.|..:|||.:..::.....|::         :..
Worm   536 TTFKSNENSATNTRSSTESTEPVTKPNTEKSSSTSVLPSDKTTSIPDTTENSK---------SSK 591

  Fly   244 YYNTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRP 308
            ..:||.||.           ..||..                                   :.:|
Worm   592 TSSTTTTTL-----------PSGSTS-----------------------------------DVKP 610

  Fly   309 GWRGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQD------------LNFCGTHEPCK 361
            .|           |.....|..||.......|    |..||.            |....|....|
Worm   611 SW-----------PATSKLSTQGSTSPASIPT----ISLDQPSSSQIAVSTTPILTAIPTASSQK 660

  Fly   362 HGGTCENTAP-DKYRCTCAEGLSGEQCEIVEHPCATRPCRNG---GT--CTLKTSNRTQAQVYRT 420
             ..|..||:| .:...:.:...|.......|.|.....|.:|   ||  |.|.....::...|::
Worm   661 -SSTSGNTSPATESSSSSSTSTSQSTSTTTEDPACKVQCPSGYLIGTSSCFLLVPASSKINSYQS 724

  Fly   421 SHG----------------RSNMG-RPVRRSSSMRSLDHLRPEGQALNGS--------------- 453
            :..                |.|.. |.::.|:.:|::|.:...|  :.|.
Worm   725 ALSYCKTTDKQSLASLDKIRDNADIRLIQESAGLRNIDWIYANG--IGGKKERFDKMADVYSIFN 787

  Fly   454 ----SSPGLVSLGSLQLQQQLA-----PDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLI 509
                |||..|::|..::.:.::     |.:            |  |..||   ..|......|..
Worm   788 QTLVSSPISVTVGISEIFENISALCVLPQY------------C--NSTEC---DVEKIFLAYDYF 835

  Fly   510 GGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVAST 574
            ..|:     |:.|.:         .|..:|..|         .:.|:..:.|.....|.:...:.
Worm   836 TSFK-----EYAGTL---------QPRRSGSVA---------CLYGNRKTFTVTCNELGAIYPNP 877

  Fly   575 S-LAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGATCIDLVNDYRCACASG 638
            | :..|..:..::.|:........||..:|..|         .:|:.......:|..|:|.|...
Worm   878 SNIDCGESVQERKIRDTTNEMVSSCKVCFGRGT---------KECQPVTNSDGVVQGYKCVCKEP 933

  Fly   639 FKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAK 686
            ||...|....:.|....|...|.|...:.:.:|.|..||:|..||:.|
Worm   934 FKMATCWRASNPCTPEACGKNGVCTSELAEVSCKCNWGYAGDRCEKEK 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	18/77 (23%)
		DSL	220..282	CDD:279722	7/61 (11%)
		EGF_CA	350..388	CDD:238011	8/50 (16%)
		EGF_CA	490..526	CDD:238011	8/35 (23%)
		EGF_CA	610..645	CDD:238011	7/34 (21%)
		EGF_CA	647..683	CDD:238011	9/35 (26%)
		EGF_CA	798..833	CDD:238011
		EGF_CA	879..913	CDD:238011
		EGF_CA	916..952	CDD:238011
		VWC_out	<993..1053	CDD:214565
Y70G10A.2	NP_499266.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158284
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930