DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and egas-2

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_507640.2	Gene:	egas-2 / 190561	WormBaseID:	WBGene00013487	Length:	919	Species:	Caenorhabditis elegans

Alignment Length:	708	Identity:	163/708 - (23%)
Similarity:	229/708 - (32%)	Gaps:	199/708 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 AGCDPVHGKCDRPGECECRPGWRGPLCNECMVYP-GCKHGSCNGSAWKCVCDTNWGGILCDQDLN 352
            |..:|.|| |...|.|...........|....|. ||...:|     .||..|..|...||..::
Worm    24 ASPNPPHG-CPNFGLCTDVTTTLVSSTNVSTTYEYGCAPENC-----YCVDGTTNGTEPCDTIVD 82

  Fly   353 FCGTHEPCKHGGTCE----NTAPDKYRCTCAEGLSGEQC-EIVEHPCATRPCRNGGTCTLKTSNR 412
            .|| .:||   |..|    .:..:.:.|.|..|.:|..| ..:...|||.|||:|.||....|:.
Worm    83 QCG-DDPC---GEPEYFLCTSKIESHTCACQAGYTGADCTSELGTACATSPCRSGATCVSSNSSA 143

  Fly   413 TQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCD 477
            |                                                          .:::|.
Worm   144 T----------------------------------------------------------TEYSCI 150

  Fly   478 CAAGWTGPTCEINIDECAGGPCEHGGTCIDLI--GGFRCECPPEWHGDVCQVDVNECEAPHSAGI 540
            |.....|..||.: :.||..||::.|.|..::  ..:.|.|.|:|.|..|:|
Worm   151 CTDQQFGTHCEYD-NLCASNPCQNSGNCTMVLENSNYLCTCSPDWQGRRCEV------------- 201

  Fly   541 AANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCIN---AKECRNQPGSFACICKEGW 602
             |:|:  :|.....|..|..|..:.|.|:.....||....|.|   .:.......::..:|
Worm   202 -ADAV--STPPVQDGCYLYDTGSIGACTTKFTENSLTSSKCNNYALEQSTDTVTMNYLTLC---- 259

  Fly   603 GGVTCAENLDDCVGQCRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMVG 667
                              ||.|  :|::......|.:...||:        ..|  ||:..:..|
Worm   260 ------------------GAWC--MVSEAPLCNTSWYMDGDCK--------KSC--GGDSAEYCG 294

  Fly   668 KFNCICPLGYSGSLCEEAKENCTPSPCL------EGHCLN----TPEGYYCHCPPDRAGKHCE-Q 721
            :.|..| :.|.....|.....||.:..|      :|.|:|    ...||.|.|.|......|| .
Worm   295 RLNSRC-IVYEAGTSETDANACTDNSTLCNANLGQGICINLSSDVTNGYQCICGPLWTDTDCETP 358

  Fly   722 LRPLCSQPPCNEG-CFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHGSCEMSDVGTFCK 785
            :...|:..||..| |..|....|..                                      |.
Worm   359 VASACTPSPCWNGICVLNEQYNTYT--------------------------------------CA 385

  Fly   786 CHVGHTGTFCEHNLNECSPNPCRNGGICLD-GDGDFTCECMSGWTGKRCSERATGCYAGQCQNGG 849
            |..|:.|..|::. :.|:.:.|..||.|.: ..|.:||.|:|.:.|..|.|.....||..|.| |
Worm   386 CDDGYFGDLCQYP-DVCTSSTCLYGGTCTETSSGGYTCSCLSQYFGTNCEEINRCNYADPCVN-G 448

  Fly   850 TCMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCR 914
            .|............|.|..||||..|...||.|...||....||......|.|.|..|.:|.:|.
Worm   449 DCQTTVDGITTNYTCTCDSGWTGENCDTMIDYCIPNPCSYNSTCSPYFKGFNCTCITGLTGANCS 513

  Fly   915 INVNECSP----------QPCQGG---ATCIDGIGGYSCICPPGRHGLRCE--ILLSD 957
            ..::.|.|          .||...   |.|...|.|::|.|........|:  :|:.|
Worm   514 TIIDLCVPYKDSTGKWIKSPCNSKDDLANCTIEINGFNCSCSDKWTDTLCDLNVLIKD 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011	11/42 (26%)
		EGF_CA	490..526	CDD:238011	11/37 (30%)
		EGF_CA	610..645	CDD:238011	6/34 (18%)
		EGF_CA	647..683	CDD:238011	7/35 (20%)
		EGF_CA	798..833	CDD:238011	11/35 (31%)
		EGF_CA	879..913	CDD:238011	12/33 (36%)
		EGF_CA	916..952	CDD:238011	10/48 (21%)
		VWC_out	<993..1053	CDD:214565
egas-2	NP_507640.2	ASC	<650..908	CDD:279230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000