DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and JAG1

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_000205.1	Gene:	JAG1 / 182	HGNCID:	6188	Length:	1218	Species:	Homo sapiens

Alignment Length:	1423	Identity:	476/1423 - (33%)
Similarity:	661/1423 - (46%)	Gaps:	344/1423 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 RSLKSACNLIALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCG---MPAELRATKTIGCS 121
            ||.:....|:||:..|......|:|.||||||.:.|.|..|.||.|||   .|.:.:.|:    .
Human     9 RSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTR----D 69

  Fly   122 PCTTAFRLCLKEYQTTEQGASISTG--CSFGNATTKILGGSSFVL-----SDPGVGAIVLPFTFR 179
            .|.|.|::||||||     :.::.|  ||||:.:|.::||::|.|     :|.  ..|||||:|.
Human    70 ECDTYFKVCLKEYQ-----SRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDR--NRIVLPFSFA 127

  Fly   180 WTKSFTLILQALDMYN-TSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVT 243
            |.:|:||:::|.|..| |..||:  :||:.|:||:|.||.:|:||......|...|::||.|...
Human   128 WPRSYTLLVEAWDSSNDTVQPDS--IIEKASHSGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDY 190

  Fly   244 YYNTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRP 308
            ||...|..|||||||.||||||...|.|.|:.||.|..|..|||:.||.|.||.|..||:|.|:.
Human   191 YYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQY 255

  Fly   309 GWRGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDK 373
            ||:|..|::|:.:|||.||.|| ..|:|:|:|||||.|||:|||:||||:||.:||||.||.|||
Human   256 GWQGLYCDKCIPHPGCVHGICN-EPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDK 319

  Fly   374 YRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMR 438
            |:|:|.||.||..|||.||.|.:.||.|.|:|.            .||.|
Human   320 YQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCK------------ETSLG--------------- 357

  Fly   439 SLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGG 503
                                               |.|:|:.|||||||..|||:|:...|.|||
Human   358 -----------------------------------FECECSPGWTGPTCSTNIDDCSPNNCSHGG 387

  Fly   504 TCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALT 568
            ||.||:.||:|.|||:|.|..||:|.|||||.
Human   388 TCQDLVNGFKCVCPPQWTGKTCQLDANECEAK--------------------------------- 419

  Fly   569 SAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGATCIDLVNDYRC 633
                       ||:|||.|:|...|:.|.|..||.|..|..|::||:|||:|.|:|.||||.|||
Human   420 -----------PCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRC 473

  Fly   634 ACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLEG- 697
            .|..|:.|..||.||||||::||.|||.|.:.:.:|.|:||.|:||:||:...:.|.|:||..|
Human   474 ICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGA 538

  Fly   698 HCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCN--EGCFANVSLATSATTTTTTTTTATTTRK 760
            .|.|....|:|.||.|..||:|..|:..|...||.  :.|  .|::|::.|
Human   539 QCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSC--TVAMASNDT-------------- 587

  Fly   761 MAKPSGL------PCSGHGSCEMSDVGTF-CKCHVGHTGTFCEHNLNECSPNPCRNGGICLDG-- 816
               |.|:      .|..||.|:....|.| |.|:.|.|||:|..|:|:|..|||||||.|:||
Human   588 ---PEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVN 649

  Fly   817 -------DG-----------------------------DFTCECMSGWTGKRCSERATGCYAGQC 845
                   ||                             ||.|:|.:||.||.|..|.:.|....|
Human   650 SYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATC 714

  Fly   846 QNGGTC----------MPG---------APDKALQPH----------------CRCAPGWTGLFC 875
            .|||||          .||         |.:.:..|:                |.|..||.|..|
Human   715 NNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPIC 779

  Fly   876 AEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSC 940
            |:..:.|...||:|.|||..|..|:||.||.||:|||||||:|||...||..||||:|.|.||.|
Human   780 AQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRC 844

  Fly   941 ICPPGRHGLRCEILLSDPKSACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGT 1005
            :||||..|.:|:.:...|   |      |:..:.:.....|           |::||.|.|.||.
Human   845 VCPPGHSGAKCQEVSGRP---C------ITMGSVIPDGAKW-----------DDDCNTCQCLNGR 889

  Fly  1006 SRCTNLWCGLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAP 1070
            ..|:.:|||...|.    |.|..:   .|...:.|:|.|.:.|...||...|:||:....
Human   890 IACSKVWCGPRPCL----LHKGHS---ECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQ----- 942

  Fly  1071 PRLPAKSSCWPNQAVVNENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDP 1135
               |.|:.| .:.:...:|||.:|.....|.:..|.:.|.:||.:|.|   .::|..::.:.
Human   943 ---PVKTKC-TSDSYYQDNCANITFTFNKEMMSPGLTTEHICSELRNL---NILKNVSAEYS--- 997

  Fly  1136 GMLMVLCDLKTGTNDTVELTVSSSKLNDPQLPV--AVGLLGELLSFRQLNGIQRRKELELQHAKL 1198
              :.:.|:.....|:.:.:.:|:..:.|...|:  ....:.:|:|.|..|.
Human   998 --IYIACEPSPSANNEIHVAISAEDIRDDGNPIKEITDKIIDLVSKRDGNS-------------- 1046

  Fly  1199 AALTSIVEVKLETARVADGSGHSLLIGVLCGVFIVLVGFSVFISLYWKQRLAYRTSSGMNLTPSL 1263
            :.:.::.||:::...:.:.:  ..|:.:|..|..|.....:..:.||..|...:..|..:..
Human  1047 SLIAAVAEVRVQRRPLKNRT--DFLVPLLSSVLTVAWICCLVTAFYWCLRKRRKPGSHTHSA--- 1106

  Fly  1264 DALRHEEEKSNNLQNEENLRRYTNPLKGSTSSLRAATGMELSLNPAP----ELAASAASSSALHR 1324
                .|:..:||::  |.|.:..||::            :...|..|    |...|..|....|.
Human  1107 ----SEDNTTNNVR--EQLNQIKNPIE------------KHGANTVPIKDYENKNSKMSKIRTHN 1153

  Fly  1325 S------------------QPLFPPCDFERELDSSTGLKQAHKRSSQILLHKTQNSDM 1364
            |                  ||.:...|.|.:..:.|..|..:      ..:|..|.|:
Human  1154 SEVEEDDMDKHQQKARFAKQPAYTLVDREEKPPNGTPTKHPN------WTNKQDNRDL 1205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	34/82 (41%)
		DSL	220..282	CDD:279722	30/61 (49%)
		EGF_CA	350..388	CDD:238011	25/37 (68%)
		EGF_CA	490..526	CDD:238011	20/35 (57%)
		EGF_CA	610..645	CDD:238011	19/34 (56%)
		EGF_CA	647..683	CDD:238011	20/35 (57%)
		EGF_CA	798..833	CDD:238011	23/72 (32%)
		EGF_CA	879..913	CDD:238011	17/33 (52%)
		EGF_CA	916..952	CDD:238011	20/35 (57%)
		VWC_out	<993..1053	CDD:214565	19/59 (32%)
JAG1	NP_000205.1	MNNL	32..106	CDD:284966	34/82 (41%)
		DSL	167..229	CDD:279722	30/61 (49%)
		Important for interaction with NOTCH1. /evidence=ECO:0000269\|PubMed:18660822	199..207		7/7 (100%)
		EGF_CA	296..334	CDD:238011	25/37 (68%)
		EGF	340..370	CDD:278437	16/91 (18%)
		EGF_CA	374..410	CDD:238011	20/35 (57%)
		EGF_CA	412..447	CDD:238011	19/78 (24%)
		EGF_CA	450..485	CDD:238011	19/34 (56%)
		EGF_CA	487..523	CDD:238011	20/35 (57%)
		EGF_CA	525..560	CDD:238011	14/34 (41%)
		EGF_CA	629..665	CDD:238011	15/35 (43%)
		EGF_CA	667..702	CDD:238011	8/34 (24%)
		EGF	748..777	CDD:278437	5/28 (18%)
		EGF_CA	782..817	CDD:238011	17/34 (50%)
		EGF_CA	820..856	CDD:238011	20/35 (57%)
		VWC_out	863..930	CDD:214565	22/90 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1152..1218		11/60 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144852
Domainoid	1	1.000	108	1.000	Domainoid score	I6432
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H180
Inparanoid	1	1.050	720	1.000	Inparanoid score	I634
Isobase	1	0.950	-	0	Normalized mean entropy	S3686
OMA	1	1.010	-	-		QHG45993
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	1	1.000	-	-		FOG0003067
OrthoInspector	1	1.000	-	-		otm40250
orthoMCL	1	0.900	-	-		OOG6_105778
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2046
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.620