DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and Notch3

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_017172782.1	Gene:	Notch3 / 18131	MGIID:	99460	Length:	2330	Species:	Mus musculus

Alignment Length:	1214	Identity:	323/1214 - (26%)
Similarity:	432/1214 - (35%)	Gaps:	441/1214 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 HYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVH-GKCDRPG-------------ECECRPGWRG 312
            |.....|...|||.||.|..|:..      ||.| |.|...|             .|.|..|::|
Mouse    57 HQQPSLEAACLCLPGWVGERCQLE------DPCHSGPCAGRGVCQSSVVAGTARFSCRCLRGFQG 115

  Fly   313 PLCNE---CMVYPGCKHGS-CN---GSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTA 370
            |.|::   |:..| |.||: |:   ...:.|.|...:.|..|..|::.|.:...|:|||||.||
Mouse   116 PDCSQPDPCVSRP-CVHGAPCSVGPDGRFACACPPGYQGQSCQSDIDECRSGTTCRHGGTCLNT- 178

  Fly   371 PDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSS 435
            |..:||.|..|.:|..||....|||..||||||||                          |:||
Mouse   179 PGSFRCQCPLGYTGLLCENPVVPCAPSPCRNGGTC--------------------------RQSS 217

  Fly   436 SMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCE 500
            .:                                   .:.|.|..|:.|..||:|:|:|.|..|.
Mouse   218 DV-----------------------------------TYDCACLPGFEGQNCEVNVDDCPGHRCL 247

  Fly   501 HGGTCIDLIGGFRCECPPEWHGDVCQVDVNECE----APHSAGIAANAL---------------- 545
            :||||:|.:..:.|:|||||.|..|..||:||:    |.|:.|...|.|
Mouse   248 NGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNLLGGHSCVCVNGWTGESC 312

  Fly   546 ---LTTTATAII--GSN-------------LSSTALLAALTSAVAST------------------ 574
               :...|||:.  |:.             :..|.||..|..|..|.
Mouse   313 SQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVSGRAI 377

  Fly   575 -------------------SLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCV-GQCR 619
                               |:...||.:...|.|..|||.|.|..|:.|..|..::::|: |.||
Mouse   378 CTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCR 442

  Fly   620 NGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEE 684
            |.|||:|.:..:.|.|.:||.|..||.|||||.:|||.|||.|.|.|..|:|.||.|:|||:|:.
Mouse   443 NQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSMCQL 507

  Fly   685 AKENCTPSPCLEG-HCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEG-CFANVSLATSATT 747
            ..:.|..:||..| .|::.|:||.|.|.....|..||:....||..||:.| |...::..:.|..
Mouse   508 DVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCERNVDDCSPDPCHHGRCVDGIASFSCACA 572

  Fly   748 TTTTTTTATTTRKMAKPSGLPCSGHG--------------------SCEM------SDVGTF--- 783
            ...|.....:  ::.:....||...|                    :||:      |:..||
Mouse   573 PGYTGIRCES--QVDECRSQPCRYGGKCLDLVDKYLCRCPPGTTGVNCEVNIDDCASNPCTFGVC 635

  Fly   784 --------CKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGD----------------------- 817
                    |.|..|.||..|...:|||:.:||..||.|:||:
Mouse   636 RDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFHCLCPPGSLPPLCLPANHPC 700

  Fly   818 --------------GDFTCECMSGWTGKRCSERAT--GCYAGQCQNGGTC--------------M 852
                          |.|.|.|..||:|.|||:...  .|.:..||.||||              .
Mouse   701 AHKPCSHGVCHDAPGGFRCVCEPGWSGPRCSQSLAPDACESQPCQAGGTCTSDGIGFRCTCAPGF 765

  Fly   853 PGAPDKALQP----------HCR----------CAPGW--------------------------- 870
            .|...:.|.|          ||.          |.|||
Mouse   766 QGHQCEVLSPCTPSLCEHGGHCESDPDRLTVCSCPPGWQGPRCQQDVDECAGASPCGPHGTCTNL 830

  Fly   871 ------------TGLFCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQ 923
                        ||.||.:.||.|...||.:||:|:.|.|.|.|.|..||:||.|..:|:||...
Mouse   831 PGNFRCICHRGYTGPFCDQDIDDCDPNPCLHGGSCQDGVGSFSCSCLDGFAGPRCARDVDECLSS 895

  Fly   924 PCQGGATCIDGIGGYSCICPPGRHGLRCEILLSD-PKSACQNAS---NTISPYTALNRSQNWLDI 984
            || |..||.|.:..::|.||||..|..|||.|.| ..|:|.|..   :.:|.::.|.|.
Mouse   896 PC-GPGTCTDHVASFTCACPPGYGGFHCEIDLPDCSPSSCFNGGTCVDGVSSFSCLCRP------ 953

  Fly   985 ALTG---RTEDDE----------NCN------ACVCENG--TSRCTNL--WCGLPNC-------- 1018
            ..||   :.|.|.          .||      .|.|..|  .|:|.|.  ||....|
Mouse   954 GYTGTHCQYEADPCFSRPCLHGGICNPTHPGFECTCREGFTGSQCQNPVDWCSQAPCQNGGRCVQ 1018

  Fly  1019 ---YKVDPLSKSSNLSGV-------------------CK-------------------------Q 1036
               |.:.|...|..|..:                   |:                         :
Mouse  1019 TGAYCICPPGWSGRLCDIQSLPCTEAAAQMGVRLEQLCQEGGKCIDKGRSHYCVCPEGRTGSHCE 1083

  Fly  1037 HEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSCWPN-QAVVNENCARLTILLALE 1100
            |||      :.|.:.||...|.||..........|...|..||..| ....::.|.
Mouse  1084 HEV------DPCTAQPCQHGGTCRGYMGGYVCECPAGYAGDSCEDNIDECASQPCQ--------- 1133

  Fly  1101 RVGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGMLMVLCDL 1144
              ..|:.::        |:|..|...|       ||.|.|||::
Mouse  1134 --NGGSCID--------LVARYLCSCP-------PGTLGVLCEI 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722	8/19 (42%)
		EGF_CA	350..388	CDD:238011	16/37 (43%)
		EGF_CA	490..526	CDD:238011	17/35 (49%)
		EGF_CA	610..645	CDD:238011	14/35 (40%)
		EGF_CA	647..683	CDD:238011	22/35 (63%)
		EGF_CA	798..833	CDD:238011	17/71 (24%)
		EGF_CA	879..913	CDD:238011	17/33 (52%)
		EGF_CA	916..952	CDD:238011	15/35 (43%)
		VWC_out	<993..1053	CDD:214565	21/134 (16%)
Notch3	XP_017172782.1	EGF_CA	159..196	CDD:238011	16/37 (43%)
		EGF_CA	237..273	CDD:238011	17/35 (49%)
		EGF_CA	275..312	CDD:238011	9/36 (25%)
		EGF_CA	315..350	CDD:238011	6/34 (18%)
		EGF_CA	392..430	CDD:238011	12/37 (32%)
		EGF_CA	432..468	CDD:238011	14/35 (40%)
		EGF_CA	470..506	CDD:238011	22/35 (63%)
		EGF_CA	508..544	CDD:238011	11/35 (31%)
		EGF_CA	546..581	CDD:238011	8/34 (24%)
		EGF_CA	584..619	CDD:238011	3/34 (9%)
		EGF_CA	621..655	CDD:238011	8/33 (24%)
		EGF_CA	659..>687	CDD:238011	10/27 (37%)
		EGF_CA	697..730	CDD:238011	7/32 (22%)
		EGF_CA	737..771	CDD:238011	8/33 (24%)
		EGF_CA	811..847	CDD:238011	2/35 (6%)
		EGF_CA	850..885	CDD:238011	17/34 (50%)
		EGF_CA	888..923	CDD:238011	15/35 (43%)
		EGF_CA	930..961	CDD:238011	8/36 (22%)
		EGF_CA	965..999	CDD:238011	7/33 (21%)
		EGF_CA	1086..1121	CDD:238011	10/40 (25%)
		EGF_CA	1123..1159	CDD:238011	12/61 (20%)
		EGF_CA	1172..1204	CDD:238011
		NL	1381..1418	CDD:197463
		NL	1422..1459	CDD:197463
		Notch	1475..1501	CDD:365847
		NOD	1506..1558	CDD:369091
		NODP	1579..1634	CDD:369464
		ANKYR	<1786..1906	CDD:223738
		ANK repeat	1801..1849	CDD:293786
		ANK repeat	1851..1882	CDD:293786
		ANKYR	1871..2037	CDD:223738
		ANK repeat	1884..1916	CDD:293786
		ANK repeat	1918..1949	CDD:293786
		ANK repeat	1951..1982	CDD:293786
		ANK repeat	1984..2015	CDD:293786
		PHA03247	<2040..2327	CDD:223021
		DUF3454	2224..2286	CDD:371809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810