| Sequence 1: | NP_001287558.1 | Gene: | Ser / 43275 | FlyBaseID: | FBgn0004197 | Length: | 1407 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_035058.2 | Gene: | Notch2 / 18129 | MGIID: | 97364 | Length: | 2473 | Species: | Mus musculus |
| Alignment Length: | 968 | Identity: | 283/968 - (29%) |
|---|---|---|---|
| Similarity: | 392/968 - (40%) | Gaps: | 223/968 - (23%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 208 TSYSGVIL--------PSPEWKTLDHIGRNARITYRVRVQC--AVTYYNTTCT-----TFCRPRD 257
Fly 258 DQFGHYACGSEGQKLCL-NGWQ--------GVNCEEAICKAGCDP-VHGKC----DRPGECECRP 308
Fly 309 GWRGPLC------------------------------------------NECMVYPGCKHGSCNG 331
Fly 332 --SAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPC 394
Fly 395 ATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLV 459
Fly 460 SLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDV 524
Fly 525 CQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRN 589
Fly 590 QPGSFACICKEGWGGVTCAENLDDCVGQ-CRNGATCIDLVNDYRCACASGFKGRDCETDIDECAT 653
Fly 654 SPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLE-GHCLNTPEGYYCHCPPDRAGK 717
Fly 718 HCEQLRPLCSQPPC-NEG----------CFANVSLATSATTTTTTTTTATTTRKMAKPSGLP--- 768
Fly 769 -CSGHGSCEMSDVGTFCKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKR 832
Fly 833 CSERATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQP-CHNGGTCESG 896
Fly 897 AGWFRCVCAQGFSGPDCRINVNECSPQPC--QGGATCIDGIGGYSCICPPGRHGLRCEILLS-DP 958
Fly 959 KSACQNASNTISPYTALNRSQNWLDIALTG--RTEDDENCNACVCENGTSRCTNLWCGLPNCYKV 1021
Fly 1022 DPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSC 1079 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Ser | NP_001287558.1 | MNNL | 83..161 | CDD:284966 | |
| DSL | 220..282 | CDD:279722 | 15/77 (19%) | ||
| EGF_CA | 350..388 | CDD:238011 | 17/37 (46%) | ||
| EGF_CA | 490..526 | CDD:238011 | 14/35 (40%) | ||
| EGF_CA | 610..645 | CDD:238011 | 15/35 (43%) | ||
| EGF_CA | 647..683 | CDD:238011 | 18/35 (51%) | ||
| EGF_CA | 798..833 | CDD:238011 | 15/34 (44%) | ||
| EGF_CA | 879..913 | CDD:238011 | 16/34 (47%) | ||
| EGF_CA | 916..952 | CDD:238011 | 12/37 (32%) | ||
| VWC_out | <993..1053 | CDD:214565 | 11/59 (19%) | ||
| Notch2 | NP_035058.2 | EGF_CA | 109..143 | CDD:238011 | |
| EGF_CA | 182..218 | CDD:238011 | |||
| EGF_CA | 260..296 | CDD:238011 | |||
| EGF_CA | 298..335 | CDD:238011 | |||
| EGF_CA | 415..454 | CDD:238011 | |||
| EGF_CA | 456..492 | CDD:238011 | |||
| EGF_CA | 495..530 | CDD:238011 | |||
| EGF_CA | 532..567 | CDD:238011 | 2/6 (33%) | ||
| EGF_CA | 570..604 | CDD:238011 | 8/49 (16%) | ||
| EGF_CA | 608..643 | CDD:238011 | 9/34 (26%) | ||
| EGF_CA | 645..679 | CDD:238011 | 10/34 (29%) | ||
| EGF_CA | 682..717 | CDD:238011 | 0/34 (0%) | ||
| EGF_CA | 757..793 | CDD:238011 | 17/37 (46%) | ||
| EGF_CA | 795..831 | CDD:238011 | 12/57 (21%) | ||
| EGF_CA | 873..909 | CDD:238011 | 14/35 (40%) | ||
| EGF_CA | 911..947 | CDD:238011 | 13/79 (16%) | ||
| EGF_CA | 949..985 | CDD:238011 | 15/35 (43%) | ||
| EGF_CA | 987..1022 | CDD:238011 | 18/34 (53%) | ||
| EGF_CA | 1025..1061 | CDD:238011 | 12/35 (34%) | ||
| EGF_CA | 1117..1147 | CDD:238011 | 8/29 (28%) | ||
| EGF_CA | 1151..1185 | CDD:238011 | 14/33 (42%) | ||
| EGF_CA | 1188..1223 | CDD:238011 | 15/38 (39%) | ||
| EGF_CA | 1225..1262 | CDD:238011 | 16/36 (44%) | ||
| EGF_CA | 1264..1302 | CDD:238011 | 12/37 (32%) | ||
| EGF_CA | <1312..1343 | CDD:238011 | 5/33 (15%) | ||
| Notch | 1423..1456 | CDD:333809 | |||
| Negative regulatory region (NRR). /evidence=ECO:0000250 | 1425..1679 | ||||
| NL | 1459..1496 | CDD:197463 | |||
| Notch | 1501..1534 | CDD:333809 | |||
| NOD | 1540..1591 | CDD:311024 | |||
| NODP | 1621..1675 | CDD:311559 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1755..1778 | ||||
| ANKYR | <1820..1932 | CDD:223738 | |||
| ANK repeat | 1828..1875 | CDD:293786 | |||
| ANK 1 | 1828..1872 | ||||
| ANK 2 | 1877..1906 | ||||
| ANK repeat | 1878..1908 | CDD:293786 | |||
| ANKYR | 1880..2067 | CDD:223738 | |||
| ANK 3 | 1910..1940 | ||||
| ANK repeat | 1944..1975 | CDD:293786 | |||
| ANK 4 | 1944..1973 | ||||
| Ank_2 | 1949..2041 | CDD:338493 | |||
| ANK repeat | 1977..2008 | CDD:293786 | |||
| ANK 5 | 1977..2006 | ||||
| ANK repeat | 2010..2041 | CDD:293786 | |||
| ANK 6 | 2010..2039 | ||||
| GGN | <2070..>2390 | CDD:317988 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2098..2117 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2122..2169 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2382..2473 | ||||
| DUF3454 | 2385..2441 | CDD:314760 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E33208_3BAFT | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.810 | |||||