DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ser and Notch1

DIOPT Version :9

Sequence 1:NP_001287558.1 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster
Sequence 2:NP_032740.3 Gene:Notch1 / 18128 MGIID:97363 Length:2531 Species:Mus musculus


Alignment Length:1073 Identity:308/1073 - (28%)
Similarity:440/1073 - (41%) Gaps:245/1073 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   224 DHIGRNARITYRVRVQCAVTYYNTTC--------TTFCRPRD----DQFGHYACGSEGQKLCLNG 276
            :|.|:..........||...|....|        :..|: .|    ||.|.:.|      :|:.|
Mouse   424 EHAGKCLNTLGSFECQCLQGYTGPRCEIDVNECISNPCQ-NDATCLDQIGEFQC------ICMPG 481

  Fly   277 WQGVNCEEAICKAGCDPV--HGKC-DRPGE--CECRPGWRGPLC----NECMVYPGCKHGS-C-- 329
            ::||.||....:....|.  :|.| |:..|  |:|..|:.|.||    :||...| ||:|: |  
Mouse   482 YEGVYCEINTDECASSPCLHNGHCMDKINEFQCQCPKGFNGHLCQYDVDECASTP-CKNGAKCLD 545

  Fly   330 NGSAWKCVCDTNWGGILCDQDLNFC--------------------------GTH----------E 358
            ..:.:.|||...:.|..|:.|::.|                          |.|          :
Mouse   546 GPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCQPGYTGHHCETNINECHSQ 610

  Fly   359 PCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQA--QVYRTS 421
            ||:|||||:: ..:.|.|.|.:|.:|..|||....||:.|| :.|||..|......|  ..|..|
Mouse   611 PCRHGGTCQD-RDNSYLCLCLKGTTGPNCEINLDDCASNPC-DSGTCLDKIDGYECACEPGYTGS 673

  Fly   422 HGRSNM----GRPVRRSSSMRSLDHLR------PEG----------------QALNGSSSPGLVS 460
            ....|:    |.|.....:..  |.:.      |||                ..::|:...||  
Mouse   674 MCNVNIDECAGSPCHNGGTCE--DGIAGFTCRCPEGYHDPTCLSEVNECNSNPCIHGACRDGL-- 734

  Fly   461 LGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVC 525
                       ..:.||||.||:|..|:||.:||...||.:||||.|:..|:.|.|...:.|..|
Mouse   735 -----------NGYKCDCAPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNC 788

  Fly   526 QVDVNECEAPHSAGIAANALLT--TTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECR 588
            |.::|||        |:|..|.  |....:.|...:........|..|.....|..||.|:..|:
Mouse   789 QTNINEC--------ASNPCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKNSGVCK 845

  Fly   589 NQPG--SFACICKEGWGGVTCAENLDDCV-GQCRNGATCIDLVNDYRCACASGFKGRDCETDIDE 650
            ....  ||:|:|..||.|.||..::::|| ..||:||:|.:....|||.|.:|:.||:||:|||:
Mouse   846 ESEDYESFSCVCPTGWQGQTCEVDINECVKSPCRHGASCQNTNGSYRCLCQAGYTGRNCESDIDD 910

  Fly   651 CATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLEG-HCLNTPEGYYCHCPPDR 714
            |..:||.|||.|.|.:....|.|..|:.|:.|||....|..:||..| :|.:..:.|.|.||...
Mouse   911 CRPNPCHNGGSCTDGINTAFCDCLPGFQGAFCEEDINECASNPCQNGANCTDCVDSYTCTCPVGF 975

  Fly   715 AGKHCEQLRPLCSQPPCNEG--CFANVSLATSATTTTTTTTTATTTR-KMAKPSGLPCSGHGSCE 776
            .|.|||...|.|::..|..|  |...::   |.|.......|.:..: .:.:....||...|:|:
Mouse   976 NGIHCENNTPDCTESSCFNGGTCVDGIN---SFTCLCPPGFTGSYCQYDVNECDSRPCLHGGTCQ 1037

  Fly   777 MSDVGTF-CKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGC 840
            .| .||: |.|..|:||..|::.:..|...||:|||.|...:..:.|||.|||||..|...:..|
Mouse  1038 DS-YGTYKCTCPQGYTGLNCQNLVRWCDSAPCKNGGRCWQTNTQYHCECRSGWTGVNCDVLSVSC 1101

  Fly   841 -YAGQ---------CQNGGTCMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCES 895
             .|.|         ||:||.|:    |:..:.:|.|..|:||.:|.:.:|:|...||.||.||..
Mouse  1102 EVAAQKRGIDVTLLCQHGGLCV----DEGDKHYCHCQAGYTGSYCEDEVDECSPNPCQNGATCTD 1162

  Fly   896 GAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICPPGRHGLRCEILLSDPKS 960
            ..|.|.|.|..|:.|.:|...:|||..||||.|.||||....|.|.||.|..|:.|||.:.|   
Mouse  1163 YLGGFSCKCVAGYHGSNCSEEINECLSQPCQNGGTCIDLTNSYKCSCPRGTQGVHCEINVDD--- 1224

  Fly   961 ACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWCGLPNCYKVDPLS 1025
             |.      .|....:||....            |...||.:.|...||                
Mouse  1225 -CH------PPLDPASRSPKCF------------NNGTCVDQVGGYTCT---------------- 1254

  Fly  1026 KSSNLSGVCKQ---HEVCVPALSETCLSSPCNVRG-------------DCRALEPSRRVAPPRLP 1074
                    |..   .|.|...::| |||:||:.||             :|||....||       
Mouse  1255 --------CPPGFVGERCEGDVNE-CLSNPCDPRGTQNCVQRVNDFHCECRAGHTGRR------- 1303

  Fly  1075 AKSSCWPNQAVVNENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGMLM 1139
                |   ::|:| .|.           ||.....|:|::........:.:.||...|       
Mouse  1304 ----C---ESVIN-GCR-----------GKPCKNGGVCAVASNTARGFICRCPAGFEG------- 1342

  Fly  1140 VLCDLKTGTNDTVELTVSSSKLNDPQLPVAVGL 1172
            ..|:....|..::......:.::.|:.|..:.|
Mouse  1343 ATCENDARTCGSLRCLNGGTCISGPRSPTCLCL 1375

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SerNP_001287558.1 MNNL 83..161 CDD:284966
DSL 220..282 CDD:279722 16/69 (23%)
EGF_CA 350..388 CDD:238011 16/73 (22%)
EGF_CA 490..526 CDD:238011 14/35 (40%)
EGF_CA 610..645 CDD:238011 14/35 (40%)
EGF_CA 647..683 CDD:238011 15/35 (43%)
EGF_CA 798..833 CDD:238011 15/34 (44%)
EGF_CA 879..913 CDD:238011 14/33 (42%)
EGF_CA 916..952 CDD:238011 18/35 (51%)
VWC_out <993..1053 CDD:214565 13/62 (21%)
Notch1NP_032740.3 EGF_CA 142..175 CDD:238011
EGF_CA 178..216 CDD:238011
EGF_CA 257..293 CDD:238011
EGF_CA 295..332 CDD:238011
EGF_CA 335..370 CDD:238011
EGF_CA 412..450 CDD:238011 5/25 (20%)
Interaction with DLL4. /evidence=ECO:0000250|UniProtKB:Q07008 420..421
Interaction with DLL4. /evidence=ECO:0000250|UniProtKB:Q07008 448..452 1/3 (33%)
EGF_CA 452..488 CDD:238011 10/42 (24%)
EGF_CA 490..526 CDD:238011 10/35 (29%)
EGF_CA 528..564 CDD:238011 11/36 (31%)
EGF_CA 566..601 CDD:238011 4/34 (12%)
EGF_CA 603..639 CDD:238011 12/36 (33%)
EGF_CA 641..675 CDD:238011 11/34 (32%)
EGF_CA 678..713 CDD:238011 7/36 (19%)
EGF_CA 717..750 CDD:238011 10/45 (22%)
EGF_CA 755..789 CDD:238011 13/33 (39%)
EGF_CA 791..827 CDD:238011 9/43 (21%)
EGF_CA 869..905 CDD:238011 14/35 (40%)
EGF_CA 907..943 CDD:238011 15/35 (43%)
EGF_CA 945..981 CDD:238011 11/35 (31%)
EGF_CA 988..1019 CDD:238011 6/33 (18%)
EGF_CA 1021..1057 CDD:238011 12/36 (33%)
EGF_CA 1146..1180 CDD:238011 14/33 (42%)
EGF_CA 1184..1219 CDD:238011 18/34 (53%)
EGF_CA 1221..1265 CDD:238011 13/89 (15%)
EGF_CA 1267..1305 CDD:238011 14/52 (27%)
NL 1442..1479 CDD:197463
LNR 1 1449..1489
Notch 1487..1522 CDD:278494
LNR 2 1490..1531
Notch 1525..1561 CDD:278494
LNR 3 1532..1571
NOD 1567..1618 CDD:284282
NODP 1662..1719 CDD:284987
Interaction with PSEN1. /evidence=ECO:0000250|UniProtKB:P46531 1718..1750
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1770..1798
Ank_2 <1863..1948 CDD:289560
ANK repeat 1870..1915 CDD:293786
ANK 1912..2024 CDD:238125
ANK repeat 1917..1948 CDD:293786
ANK 1 1917..1946
Ank_2 1922..2015 CDD:289560
HIF1AN-binding 1937..1945
ANK repeat 1950..1981 CDD:293786
ANK 2 1950..1980
ANK 1979..2103 CDD:238125
ANK repeat 1984..2015 CDD:293786
ANK 3 1984..2013
Ank_2 1989..2081 CDD:289560
HIF1AN-binding 2004..2012
ANK repeat 2017..2081 CDD:293786
ANK 4 2017..2046
ANK 5 2050..2079
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2140..2185
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2382..2428
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2440..2531
DUF3454 2454..2516 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 64 1.000 Domainoid score I10116
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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