DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser and apx-1

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_503882.2	Gene:	apx-1 / 178759	WormBaseID:	WBGene00000168	Length:	515	Species:	Caenorhabditis elegans

Alignment Length:	463	Identity:	107/463 - (23%)
Similarity:	170/463 - (36%)	Gaps:	139/463 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 NLIALILILLVHKISAAGNFELEILEISNTNSHLLN-----GYCCGMPAELRATKTIGCSPCTTA 126
            :|:..|.:.::.  ||.|:..:|:| ||:..:.|:.     .:.|..|.:|...:.:       .
Worm     6 SLLTTIFLCIIS--SATGSGTIELL-ISSPQTVLVEPTVCANFECAAPDDLSLARKV-------Q 60

  Fly   127 FRLCLKEYQTTEQGASISTGCSFGNATTKILGGSSFVLSDPGVGAIVLPFTFRWTKSFTLILQ-- 189
            .|:.|:          ..||...|.|..:|  .....:.:|             |.:..|.||
Worm    61 RRVPLR----------FGTGQYHGEARERI--DLHLKIIEP-------------TSNEILALQHH 100

  Fly   190 --ALDM-YNTSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCTT 251
              |.|. :|:..|    ::.|||                  |...:|.::|..|:..|:...|..
Worm   101 RPAADTEWNSDAP----IVIETS------------------RGFNVTVQLRNLCSSNYHGKRCNR 143

  Fly   252 FCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLCN 316
            :|......  |:.|.:.|.:.|..||.|.:|...||..||.. .|:|..|.:|.|..|:.|..|.
Worm   144 YCIANAKL--HWECSTHGVRRCSAGWSGEDCSNPICAGGCSN-RGRCVAPNQCSCADGFNGTRCE 205

  Fly   317 ECMVYPGCKHGSC-NGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTC--ENTAPDKYRCTC 378
            :|:...||.:|.| |.:...|.|...:.|..||.|:..|...:||.:||.|  ::::...|:|.|
Worm   206 QCLPRAGCVNGDCVNETPNTCKCRDGFIGDRCDIDIKICSLEKPCANGGICSIDSSSSTGYKCHC 270

  Fly   379 AEGLSGEQCE--IVEHPC-ATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSL 440
            .....|.||:  :.:..| |...|:|||.|
Worm   271 PFEFVGSQCKTPLSKVRCSAEHVCKNGGAC----------------------------------- 300

  Fly   441 DHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEI-NIDECAGGPCEHGGT 504
                              :|:....:|        |.|..|::|..||| |..:|:...|..|.|
Worm   301 ------------------ISMDDTNIQ--------CKCRRGFSGKFCEIGNHGDCSAMRCSAGET 339

  Fly   505 CIDLIGGF 512
            | .:.|.|
Worm   340 C-QISGDF 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	16/82 (20%)
		DSL	220..282	CDD:279722	14/61 (23%)
		EGF_CA	350..388	CDD:238011	12/39 (31%)
		EGF_CA	490..526	CDD:238011	8/23 (35%)
		EGF_CA	610..645	CDD:238011
		EGF_CA	647..683	CDD:238011
		EGF_CA	798..833	CDD:238011
		EGF_CA	879..913	CDD:238011
		EGF_CA	916..952	CDD:238011
		VWC_out	<993..1053	CDD:214565
apx-1	NP_503882.2	DSL	108..172	CDD:302925	19/87 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I7005
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.880