DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser and glp-1

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_499014.1	Gene:	glp-1 / 176286	WormBaseID:	WBGene00001609	Length:	1295	Species:	Caenorhabditis elegans

Alignment Length:	769	Identity:	200/769 - (26%)
Similarity:	285/769 - (37%)	Gaps:	208/769 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   563 LLAALTSAVASTSLAIGPC-------INAKECRNQP--GSFACICKEGWGGVTCAENLDDCVGQC 618
            :|.|..:.:|| .|..|.|       :|.| |.|..  .::.|.||:|:||..|..   :|...|
Worm     6 ILLAFFAPIAS-QLMGGECGREGACSVNGK-CYNGKLIETYWCRCKKGFGGAFCER---ECDLDC 65

  Fly   619 RNGATCI-DLVND------YRC------------ACASGFKGRDCET----DIDECATSPCRNGG 660
            :.|..|| |:..:      ..|            .|..|:.|.||:|    .::.|.:.|| |.|
Worm    66 KRGEKCIYDVYGENPTCICQDCEDETPPTERTQKGCEEGYGGPDCKTPLFSGVNPCDSDPC-NNG 129

  Fly   661 ECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLEGH-CLNTPEGYYCHCPPDRAGKHCEQLRP 724
            .|....|.|.|||..||.||.|||..::|..:.|.||. |:|:...|||.||..::|::||:...
Worm   130 LCYPFYGGFQCICNNGYGGSYCEEGIDHCAQNECAEGSTCVNSVYNYYCDCPIGKSGRYCERTEC 194

  Fly   725 LCSQPPCNEG-CFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHGSCEMSDVGTFCKCHV 788
            ......||.| |..|                                     ...|....|.|..
Worm   195 ALMGNICNHGRCIPN-------------------------------------RDEDKNFRCVCDS 222

  Fly   789 GHTGTFCEHNLNEC-SPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCM 852
            |:.|.||..:.||| ....|.|...|.:..|||||.|..|:.||.|.|....|....|||.|.|
Worm   223 GYEGEFCNKDKNECLIEETCVNNSTCFNLHGDFTCTCKPGYAGKYCEEAIDMCKDYVCQNDGYC- 286

  Fly   853 PGAPDKALQPHCRCAPGWTGLFCAEAIDQCRG---------QP--------CHNGGTCESGAGWF 900
              |.|....|.|.|..|:||..|........|         :|        |:|.|.|.:|.
Worm   287 --AHDSNQMPICYCEQGFTGQRCEIECPSGFGGIHCDLPLQRPHCSRSNGTCYNDGRCINGF--- 346

  Fly   901 RCVCAQGFSGPDCRIN--------VNECSPQPCQGGATCID-GIGGYSCICPPGRHGLRCE-ILL 955
             |||...:.|..|.||        :..|...||...||||| ...||||.||.|.:||.|| .||
Worm   347 -CVCEPDYIGDRCEINRKDFKFPDIQSCKYNPCVNNATCIDLKNSGYSCHCPLGFYGLNCEQHLL 410

  Fly   956 SDPKS-----ACQNASNTISPYTALNRSQNWLDIALTGRTEDDENC------NACVCEN-GTSRC 1008
            ..|.:     .|:..:..|........|.::.:|      :|.:.|      |..||:| |...|
Worm   411 CTPTTCANGGTCEGVNGVIRCNCPNGFSGDYCEI------KDRQLCSRHPCKNGGVCKNTGYCEC 469

  Fly  1009 TNLWCGLPNCYKVDPLSKSSN--LSGVCKQHEVCVPALSETCLSSPCNVR------GDCRALEPS 1065
            ...:.| |.|.:|..:.||..  :..:|:|.: |:...|....:..||:.      |||..  ..
Worm   470 QYGYTG-PTCEEVLVIEKSKETVIRDLCEQRK-CMDLASNGICNPECNLEECNFDGGDCSG--GQ 530

  Fly  1066 RRVAPPRLPAKSSCWPNQAVVNENCARLTILL-------------------ALERVGKGASVEGL 1111
            |..:..:.||:.:......|.|:.|.....|.                   .:||.|     :|:
Worm   531 RPFSKCQYPARCADQFANGVCNQECNNEECLYDGLDCQSELFRCPAHIRKHCIERRG-----DGV 590

  Fly  1112 CSLVRVLLAAQLIKKPASTFGQDPGMLMVLCDLKTGTNDTVELTVSSSKLNDPQLPVAVGLLGEL 1176
            |:|....:..          |.|.|      |...||...:        |:|.::.|.:    :.
Worm   591 CNLECSFIGC----------GFDGG------DCNNGTEAII--------LSDIRIKVQI----DP 627

  Fly  1177 LSFRQLNG-------IQRRKELELQHAKLAALT-------SIVEVKLETARVAD 1216
            :.|:...|       ...|..:.:|..:|..|.       .:..|::.::::.|
Worm   628 IEFQATGGETLMQISANLRATVRIQRDELGPLVFRWDGEHEMERVEMNSSKLED 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011
		EGF_CA	490..526	CDD:238011
		EGF_CA	610..645	CDD:238011	11/53 (21%)
		EGF_CA	647..683	CDD:238011	15/35 (43%)
		EGF_CA	798..833	CDD:238011	15/35 (43%)
		EGF_CA	879..913	CDD:238011	11/50 (22%)
		EGF_CA	916..952	CDD:238011	18/44 (41%)
		VWC_out	<993..1053	CDD:214565	17/68 (25%)
glp-1	NP_499014.1	EGF_CA	118..152	CDD:238011	15/34 (44%)
		EGF_CA	155..190	CDD:238011	12/34 (35%)
		EGF_CA	232..269	CDD:238011	15/36 (42%)
		EGF_CA	369..406	CDD:238011	17/36 (47%)
		EGF_CA	451..479	CDD:238011	8/28 (29%)
		NL	489..526	CDD:197463	7/37 (19%)
		Notch	533..568	CDD:278494	6/34 (18%)
		Notch	573..608	CDD:278494	10/55 (18%)
		NOD	612..661	CDD:284282	9/60 (15%)
		NODP	698..755	CDD:284987
		ANK repeat	921..959	CDD:293786
		ANK	926..1054	CDD:238125
		Ank_5	949..1002	CDD:290568
		ANK	956..1127	CDD:238125
		ANK repeat	961..992	CDD:293786
		ANK repeat	994..1028	CDD:293786
		Ank_2	999..1105	CDD:289560
		ANK repeat	1030..1061	CDD:293786
		ANK repeat	1071..1105	CDD:293786
		Ank_2	1079..1171	CDD:289560
		ANK repeat	1107..1138	CDD:293786
		ANK repeat	1140..1170	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810