DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and lin-12

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_499007.1	Gene:	lin-12 / 176282	WormBaseID:	WBGene00003001	Length:	1429	Species:	Caenorhabditis elegans

Alignment Length:	1309	Identity:	292/1309 - (22%)
Similarity:	429/1309 - (32%)	Gaps:	501/1309 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 GSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVE 391
            |||.|.                    .||.:..| |.|....| ...|.|.|.||..||.|   |
Worm    22 GSCLGL--------------------ICGRNGHC-HAGPVNGT-QTSYWCRCDEGFGGEYC---E 61

  Fly   392 HPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSP 456
            ..|....|.....|......|.:..|.:...                           :||:|
Worm    62 QQCDVSKCGADEKCVFDKDYRMETCVCKDCD---------------------------INGNS-- 97

  Fly   457 GLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWH 521
                        .|.|    .|.:|:.|..|:.. ..|....|.:||.||......:|.||..:.
Worm    98 ------------LLKP----SCPSGYGGDDCKTQ-GWCYPSVCMNGGQCIGAGNRAKCACPDGFK 145

  Fly   522 GDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKE 586
            |:.|::||||||...:|                                          |.|...
Worm   146 GERCELDVNECEENKNA------------------------------------------CGNRST 168

  Fly   587 CRNQPGSFACICKEGWGGVTC---------------------AENLDDCVGQCRNGATCIDLVND 630
            |.|..|::.|:|.:|:....|                     |::.|.....|:||..| |..:.
Worm   169 CMNTLGTYICVCPQGFLPPDCLKPGNTSTVEFKQPVCFLEISADHPDGRSMYCQNGGFC-DKASS 232

  Fly   631 YRCACASGFKGRDCE--TDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSP 693
             :|.|..|:.|..||  ...|.||::||.: |.|:...|.|.|||..|||||.|:|.|:||..:.
Worm   233 -KCQCPPGYHGSTCELLEKEDSCASNPCSH-GVCISFSGGFQCICDDGYSGSYCQEGKDNCVNNK 295

  Fly   694 CLEG-HCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPP--CNEGCFANVSLATSATTTTTTTTTA 755
            |..| .|:|....|:|.|||:|.|.:||::.  ||..|  ||
Worm   296 CEAGSKCINGVNSYFCDCPPERTGPYCEKMD--CSAIPDICN----------------------- 335

  Fly   756 TTTRKMAKPSGLPCSGHGSC---EMSDVGTFCKCHVGHTGTFCEHNLNEC-SPNPCRNGGICLDG 816
                            ||:|   .:|:....|:|..|:.|..||.:.||| |.|.|.|.|.|::.
Worm   336 ----------------HGTCIDSPLSEKAFECQCEPGYEGILCEQDKNECLSENMCLNNGTCVNL 384

  Fly   817 DGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGLFCAE---- 877
            .|.|.|:|..|:.||.|.|....|....|:|.||||..:..   .|.|:|..|:.|..|.:
Worm   385 PGSFRCDCARGFGGKWCDEPLNMCQDFHCENDGTCMHTSDH---SPVCQCKNGFIGKRCEKECPI 446

  Fly   878 -----------AIDQC--RGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRIN---------VNEC 920
                       .|..|  :|..|.|||.|.||.    |||...|:|..|.:|         .|.|
Worm   447 GFGGVRCDLRLEIGICSRQGGKCFNGGKCLSGF----CVCPPDFTGNQCEVNRKNGKSSLSENLC 507

  Fly   921 SPQPCQGGATCID-------------GIGG---------------------------YSCICPPG 945
            ...||...|||||             |..|                           :||.||||
Worm   508 LSDPCMNNATCIDVDAHIGYACICKQGFEGDICERHKDLCLENPCSNGGVCHQHRESFSCDCPPG 572

  Fly   946 RHGLRC--EILLSDPKSACQNASNTISPYTALNRSQNWL---------------DIALTGRTEDD 993
            .:|..|  |.:....||.|||..      ..:|..:...               .|.|||.||.|
Worm   573 FYGNGCEQEKMFRCLKSTCQNGG------VCINEEEKGRKCECSYGFSGARCEEKINLTGFTEKD 631

  Fly   994 E----------------------NCNACVCENGTSRCTNLWCGLPNCYKVDPLSKS--SNL---- 1030
            .                      :||...|:.....|:.         |.:|.||.  .|:
Worm   632 SLLRSVCEKRKCSERANDGNCDADCNYAACKFDGGDCSG---------KREPFSKCRYGNMCADF 687

  Fly  1031 --SGVCKQ----HEV------CVPA-------LSETCLS--------SPCNVR------GDC--- 1059
              :|||.|    .|.      |:||       :.|.|.|        ..||..      |||
Worm   688 FANGVCNQACNNEECLYDGMDCLPAVVRCPVKIREHCASRFANGICDPECNTNGCGFDGGDCDNE 752

  Fly  1060 --RALEPSRRVAPPRLPAKSSCWPNQAVVNENCARLTILLALERVGKGASV---EGLCSLVRVLL 1119
              ..:..:.|:.....|.:......|::: |..:.|.:.:.::|..:|..|   .|...:.||.:
Worm   753 TNATIITNIRITVQMDPKEFQVTGGQSLM-EISSALRVTVRIQRDEEGPLVFQWNGESEMDRVKM 816

  Fly  1120 --------------AAQLIKKPASTFGQDPGMLMVL-----CDLKTG---------TNDTVELTV 1156
                          .::.||:.|:..    |:::.|     ||  ||         ..|::...:
Worm   817 NERQLTEQHVLSTSISRKIKRSATNI----GVVVYLEVQENCD--TGKCLYKDAQSVVDSISARL 875

  Fly  1157 SSSKLNDPQLPVAVGLLGE---------LLSFRQLNGIQRRKELELQHAKLAALTSIVEVKLETA 1212
            :...::...:|::..|:.|         .||:..|
Worm   876 AKKGIDSFGIPISEALVAEPRKSGNNTGFLSWNAL------------------------------ 910

  Fly  1213 RVADGSGHSLLIGVLCGVFIVLVGFSVFISLYWKQRLAYRTSSGMNLTPSLDALRHEEEKSNNLQ 1277
                     ||||..|.:.:|::..........::|.....|..|   |.::   :||:...|.|
Worm   911 ---------LLIGAGCLIVMVVLMLGALPGNRTRKRRMINASVWM---PPME---NEEKNRKNHQ 960

  Fly  1278 N-------------EENLRRYTNPLK-----------GSTSSLRA---ATGMELSLNPAPE---- 1311
            :             :..::|..|.|:           |:.:....   .|.:::...|.||
Worm   961 SITSSQHSLLEASYDGYIKRQRNELQHYSLYPNPQGYGNGNDFLGDFNHTNLQIPTEPEPESPIK 1025

  Fly  1312 LAASAASSSALHRSQPLFPPCDFERE----LDSSTGLKQAH--------KRSSQILLHKTQNSDM 1364
            |...||.|.|:  ::|:      .||    :|........|        ::|..:::|:.:....
Worm  1026 LHTEAAGSYAI--TEPI------TRESVNIIDPRHNRTVLHWIASNSSAEKSEDLIVHEAKECIA 1082

  Fly  1365 RKNTVGSLD 1373
            ....|.::|
Worm  1083 AGADVNAMD 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011	13/37 (35%)
		EGF_CA	490..526	CDD:238011	10/35 (29%)
		EGF_CA	610..645	CDD:238011	10/34 (29%)
		EGF_CA	647..683	CDD:238011	17/35 (49%)
		EGF_CA	798..833	CDD:238011	16/35 (46%)
		EGF_CA	879..913	CDD:238011	15/35 (43%)
		EGF_CA	916..952	CDD:238011	20/86 (23%)
		VWC_out	<993..1053	CDD:214565	21/114 (18%)
lin-12	NP_499007.1	EGF_CA	152..189	CDD:238011	15/78 (19%)
		EGF_CA	252..285	CDD:238011	17/33 (52%)
		EGF_CA	293..323	CDD:238011	11/29 (38%)
		EGF_CA	365..401	CDD:238011	16/35 (46%)
		EGF_CA	505..541	CDD:238011	11/35 (31%)
		EGF_CA	545..579	CDD:238011	7/33 (21%)
		NL	635..668	CDD:197463	3/32 (9%)
		Notch	675..709	CDD:278494	8/33 (24%)
		Notch	722..750	CDD:278494	7/27 (26%)
		NOD	754..804	CDD:284282	8/50 (16%)
		NODP	842..898	CDD:284987	10/61 (16%)
		ANK	1046..1186	CDD:238125	6/46 (13%)
		ANK repeat	1052..1091	CDD:293786	4/38 (11%)
		Ank_4	1053..1113	CDD:290365	5/39 (13%)
		ANK repeat	1093..1124	CDD:293786
		Ank_4	1094..1147	CDD:290365
		ANK repeat	1126..1160	CDD:293786
		ANK	1160..1292	CDD:238125
		ANK repeat	1162..1201	CDD:293786
		Ank_2	1167..1271	CDD:289560
		ANK repeat	1203..1238	CDD:293786
		ANK repeat	1240..1271	CDD:293786
		Pap_E4	1306..>1373	CDD:280813
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810