DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and Crb1

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_573502.2	Gene:	Crb1 / 170788	MGIID:	2136343	Length:	1405	Species:	Mus musculus

Alignment Length:	1521	Identity:	286/1521 - (18%)
Similarity:	387/1521 - (25%)	Gaps:	800/1521 - (52%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 NTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGV--NCEEAICKAGCDPVHG--KCDR-PGE-- 303
            |:||..|  |:|:.     |       ||:....:  :||:........|..|  .|.: |||
Mouse    42 NSTCKHF--PQDNN-----C-------CLDTANNLDKDCEDLKDPCFSSPCQGIATCVKIPGEGN 92

  Fly   304 --CECRPGWRGPLC----NECMVYPG---CKHGSCNGSAWK------CVCDTNWGGILCDQDLNF 353
              |:|.||:.|..|    |.|    |   |:||   |:..|      |:|...:.|..|:.|.|.
Mouse    93 FLCQCPPGYSGLNCETATNSC----GGNLCQHG---GTCRKDPEHPVCICPPGYAGRFCETDHNE 150

  Fly   354 CGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVY 418
            |.: .||.:|..|:: ..:.|.|.|..|..|..|::....|.:.||:|...|.
Mouse   151 CAS-SPCHNGAMCQD-GINGYSCFCVPGYQGRHCDLEVDECVSDPCKNEAVCL------------ 201

  Fly   419 RTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWT 483
                  :.:||                                            :||.|...::
Mouse   202 ------NEIGR--------------------------------------------YTCVCPQEFS 216

  Fly   484 GPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTT 548
            |..||:.||||...||.||.||.|..||:.|:|.|.:.|:.|::.|||||:.
Mouse   217 GVNCELEIDECRSQPCLHGATCQDAPGGYSCDCAPGFLGEHCELSVNECESQ------------- 268

  Fly   549 TATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICK-EGWGGVTCAENLD 612
                                           ||::...|.:...|:.|.|. .|:.|:.|...:.
Mouse   269 -------------------------------PCLHGGLCVDGRNSYHCDCTGSGFTGMHCESLIP 302

  Fly   613 DCVGQ-CRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDM----------- 665
            .|..: |.|.|||.|.|:.|.|.|..|:.|..|||||:||:::||:..||||::
Mouse   303 LCWSKPCHNDATCEDTVDSYICHCRPGYTGALCETDINECSSNPCQFWGECVELSSEGLYGNTAG 367

  Fly   666 -------VGK--FNCICPLGYSGSLCEEAKENCTPSPCLE-GHCLNTPEGYYCHCPPD------R 714
                   ||.  :.|||..|::|..|||..:.|...|||. |.|.|.|..|.||||.|      .
Mouse   368 LPSSFSYVGASGYVCICQPGFTGIHCEEDVDECLLHPCLNGGTCENLPGNYACHCPFDDTSRTFY 432

  Fly   715 AGKHCEQL-----------------------------------RPLCSQ---------------- 728
            .|::|.::                                   .|||..
Mouse   433 GGENCSEILLGCTHHQCLNNGKCIPHFQNGQHGFTCQCLSGYAGPLCETVTTLSFGSNGFLWVTS 497

  Fly   729 -------PPCN-----------------------------EGC-------------FANVSLATS 744
                   |.||                             .||             ..::|..||
Mouse   498 GSHTGIGPECNISLRFHTVQPNALLLIRGNKDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTS 562

  Fly   745 -------ATTTTTTTTTATT--------TRKMAKP------------------------------ 764
                   ..|...|.|.|..        |.|.:.|
Mouse   563 DGEWHFVEVTIAETLTLALVGGSCKEKCTTKSSVPVENHQSICALQDSFLGGLPMGTANNSVSVL 627

  Fly   765 -------------------------------SGL-----------------PCSGHGSCEMSDVG 781
                                           |||                 ||...|.|.....|
Mouse   628 NIYNVPSTPSFVGCLQDIRFDLNHITLENVSSGLSSNVKAGCLGKDWCESQPCQNRGRCINLWQG 692

  Fly   782 TFCKCHVGHTGTFC--------------------------------------------------- 795
            ..|:|...:||:.|
Mouse   693 YQCECDRPYTGSNCLKEYVAGRFGQDDSTGYAAFSVNDNYGQNFSLSMFVRTRQPLGLLLALENS 757

  Fly   796 ---------EH-------------------------------------------NL--------- 799
                     ||                                           ||
Mouse   758 TYQYVSVWLEHGSLALQTPGSPKFMVNFFLSDGNVHLISLRIKPNEIELYQSSQNLGFISVPTWT 822

  Fly   800 ----------------------------------------------------------------- 799

Mouse   823 IRRGDVIFIGGLPDREKTEVYGGFFKGCVQDVRLNSQTLEFFPNSTNNAYDDPILVNVTQGCPGD 887

  Fly   800 NECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGCY------AGQCQ---NGGTCMPGA 855
            |.|..|||.|||:|.....||:|.|.:...|:.| |:...|.      ..:||   .|..|:..|
Mouse   888 NTCKSNPCHNGGVCHSLWDDFSCSCPTNTAGRAC-EQVQWCQLSPCPPTAECQLLPQGFECIANA 951

  Fly   856 PDKALQP-------------------------------HCRCAP--------------------- 868
            ....|..                               |....|
Mouse   952 VFSGLSREILFRSNGNITRELTNITFAFRTHDTNVMILHAEKEPEFLNISIQDARLFFQLRSGNS 1016

  Fly   869 ---------------GW-------------TGLFCAEAIDQ------------------------ 881
                           .|             |..:..|..||
Mouse  1017 FYTLHLMGSQLVNDGTWHQVTFSMIDPVAQTSRWQMEVNDQTPFVISEVATGSLNFLKDNTDIYV 1081

  Fly   882 ------------------------------------------------------------CRGQP 886
                                                                        |...|
Mouse  1082 GDQSVDNPKGLQGCLSTIEIGGIYLSYFENLHGFPGKPQEEQFLKVSTNMVLTGCLPSNACHSSP 1146

  Fly   887 CHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICPPGRHGLRC 951
            |.:||.||.....:||.|..|:||..|.||::||...||..| .|.||:..|.|.|.||..|:.|
Mouse  1147 CLHGGNCEDSYSSYRCACLSGWSGTHCEINIDECFSSPCIHG-NCSDGVAAYHCRCEPGYTGVNC 1210

  Fly   952 EILLSDPKS-ACQNASNTISP---YTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLW 1012
            |:.:.:.|| .|.|.:..:..   |:.|....      .|||........:.||.|.....|
Mouse  1211 EVDVDNCKSHQCANGATCVPEAHGYSCLCFGN------FTGRFCRHSRLPSTVCGNEKRNFT--- 1266

  Fly  1013 CGLPNCYKVDPLSKSSNLSGVCKQHE-----VCVPALS--------ETCLSSPCNVRGDCRALEP 1064
                 ||.          .|.|...:     :|.|..:        ..|.|.||...|.||
Mouse  1267 -----CYN----------GGSCSMFQEDWQCMCWPGFTGEWCEEDINECASDPCINGGLCR---- 1312

  Fly  1065 SRRVAPPRLPAKSSCWPNQAVVNENC----ARLTILLALERVGKGASVEGLCSLVRVLLAAQLIK 1125
                   .|..:..|..:.|...|.|    |...:|.....||.|.     .:|..:||.|
Mouse  1313 -------DLVNRFLCICDVAFAGERCELDLADDRLLGIFTAVGSGT-----LALFFILLLA---- 1361

  Fly  1126 KPASTFGQDPGMLMVLCDLKTGTNDT 1151
                      |:..::...|..|..|
Mouse  1362 ----------GVASLIASNKRATQGT 1377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722	9/37 (24%)
		EGF_CA	350..388	CDD:238011	12/37 (32%)
		EGF_CA	490..526	CDD:238011	17/35 (49%)
		EGF_CA	610..645	CDD:238011	13/35 (37%)
		EGF_CA	647..683	CDD:238011	17/55 (31%)
		EGF_CA	798..833	CDD:238011	16/108 (15%)
		EGF_CA	879..913	CDD:238011	15/117 (13%)
		EGF_CA	916..952	CDD:238011	15/35 (43%)
		VWC_out	<993..1053	CDD:214565	12/72 (17%)
Crb1	NP_573502.2	EGF	113..143	CDD:394967	10/36 (28%)
		EGF_CA	147..182	CDD:238011	12/36 (33%)
		EGF_CA	186..221	CDD:238011	11/96 (11%)
		EGF_CA	224..259	CDD:238011	17/34 (50%)
		EGF_CA	262..298	CDD:238011	13/79 (16%)
		EGF_CA	<308..336	CDD:238011	12/27 (44%)
		EGF_CA	338..394	CDD:238011	17/55 (31%)
		EGF_CA	396..437	CDD:214542	15/40 (38%)
		Laminin_G_2	513..648	CDD:396680	12/134 (9%)
		EGF_CA	675..706	CDD:238011	9/30 (30%)
		Laminin_G_2	742..859	CDD:396680	4/116 (3%)
		EGF_CA	888..922	CDD:238011	15/34 (44%)
		Laminin_G_2	979..1104	CDD:396680	7/124 (6%)
		EGF_CA	1140..1174	CDD:238011	13/33 (39%)
		EGF_CA	1176..1211	CDD:238011	15/35 (43%)
		EGF_CA	1213..1248	CDD:238011	9/40 (23%)
		EGF_CA	1296..1332	CDD:238011	11/46 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900