DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and Jag2

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_011242300.1	Gene:	Jag2 / 16450	MGIID:	1098270	Length:	1254	Species:	Mus musculus

Alignment Length:	1388	Identity:	490/1388 - (35%)
Similarity:	635/1388 - (45%)	Gaps:	346/1388 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 IALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGC--SPCTTAFRLCL 131
            :.|:|:|.|......|.|||::..:.|.|..||:|.||  ..:.|.|:..||  ..|.|..|:||
Mouse    13 LLLLLVLCVQATRPMGYFELQLSALRNVNGELLSGACC--DGDGRTTRAGGCGRDECDTYVRVCL 75

  Fly   132 KEYQTTEQGASIS-TG-CSFGNATTKILGGSSFVL-------------------SDPGVGAIVLP 175
            ||||     |.:: || ||:|...|.:|||:||.|                   .|||:  :|:|
Mouse    76 KEYQ-----AKVTPTGPCSYGYGATPVLGGNSFYLPPAGAAGDRARARSRTGGHQDPGL--VVIP 133

  Fly   176 FTFRWTKSFTLILQALDMYNTSYPDA-------ERLIEETSYSGVILPSPEWKTLDHIGRNARIT 233
            |.|.|.:|||||::|.|..|.:.|||       |.|||..|::|:|.|...||:|...|..|.:.
Mouse   134 FQFAWPRSFTLIVEAWDWDNDTTPDANSAAPKEELLIERVSHAGMINPEDRWKSLHFSGHVAHLE 198

  Fly   234 YRVRVQCAVTYYNTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKC 298
            .::||:|...||:.||..|||||:|.||||.|...|.|.|::||.|..|:||:||.||:.:||.|
Mouse   199 LQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGC 263

  Fly   299 DRPGECECRPGWRGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHG 363
            ..||||.|..||:|..|:||:.||||.|||| ...|.|.|:|||||:|||:|||:||:|.||.:|
Mouse   264 TVPGECRCSYGWQGKFCDECVPYPGCVHGSC-VEPWHCDCETNWGGLLCDKDLNYCGSHHPCVNG 327

  Fly   364 GTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMG 428
            |||.|..||:|.|.|.:|..|:.||..||.||:.||.|||:|
Mouse   328 GTCINAEPDQYLCACPDGYLGKNCERAEHACASNPCANGGSC----------------------- 369

  Fly   429 RPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDE 493
                         |..|.|                          |.|.|.:||.||||.::|||
Mouse   370 -------------HEVPSG--------------------------FECHCPSGWNGPTCALDIDE 395

  Fly   494 CAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNL 558
            ||..||..||||:|.:.||.|.||.:|.|..||:|.||||..
Mouse   396 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGK----------------------- 437

  Fly   559 SSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGAT 623
                                 ||:||..|:|..|.:.|.|..||.|:.|..|::||.|||::|.|
Mouse   438 ---------------------PCLNAFSCKNLIGGYYCDCLPGWKGINCQININDCHGQCQHGGT 481

  Fly   624 CIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKEN 688
            |.||||.|:|.|..||.||.||.:.|:||:||||.||.|.|:|..|.|.||.|.||..||...:.
Mouse   482 CKDLVNGYQCVCPRGFGGRHCELEYDKCASSPCRRGGICEDLVDGFRCHCPRGLSGLHCEVDMDL 546

  Fly   689 CTPSPCLEG-HCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCN--EGC-FANVSLATSATTTT 749
            |.|||||.| .|.|....|||.||.|..||:|...|..|....|.  :|| |...|.|....
Mouse   547 CEPSPCLNGARCYNLEGDYYCACPEDFGGKNCSVPRDTCPGGACRVIDGCGFEAGSRARGVA--- 608

  Fly   750 TTTTTATTTRKMAKPSGLPCSGHGSCEMSDVGTF-CKCHVGHTGTFCEHNLNECSPNPCRNGGIC 813
                          |||: |..||.|.....|.| |.|..|.|||:|..|:::|...||||||.|
Mouse   609 --------------PSGI-CGPHGHCVSLPGGNFSCICDSGFTGTYCHENIDDCMGQPCRNGGTC 658

  Fly   814 LD--------------GD------------------------GDFTCECMSGWTGKRCSERATGC 840
            :|              |:                        .||.|.|..||.||.|..|...|
Mouse   659 IDEVDSFRCFCPSGWEGELCDINPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC 723

  Fly   841 YAGQCQNGGTCM-----------PG--------APDKALQPH----------------CRCAPGW 870
            .|..|.|||||.           ||        |.:.:..|:                |.|..||
Mouse   724 DAYTCSNGGTCYDSGDTFRCACPPGWKGSTCTIAKNSSCVPNPCVNGGTCVGSGDSFSCICRDGW 788

  Fly   871 TGLFCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGI 935
            .|..|....:.|...||:|||.|..|..||||.||.||:|||||||::||...||..||||:|.|
Mouse   789 EGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEI 853

  Fly   936 GGYSCICPPGRHGLRCE--ILLSDPKSACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNA 998
            .||.|.|||||.|.||:  ::.:.|   |.:...:. |:     ..:|:           |:||:
Mouse   854 NGYRCSCPPGRSGPRCQEVVIFTRP---CWSRGMSF-PH-----GSSWM-----------EDCNS 898

  Fly   999 CVCENGTSRCTNLWCGLPNCYKVDPLS-KSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRAL 1062
            |.|.:|...|:.:|||...|.    || :.|:.|..|...:.|.......||..||...|:|.|.
Mouse   899 CRCLDGHRDCSKVWCGWKPCL----LSGQPSDPSAQCPPGQQCQEKAVGQCLQPPCENWGECTAE 959

  Fly  1063 EPSRRVAPPRLPAKSSCWPNQAVVNENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKP 1127
            ||        ||..:.|.|..:.::.||||||:....::|.:|.:|..:||.:|.|        |
Mouse   960 EP--------LPPSTPCQPRSSHLDNNCARLTLRFNRDQVPQGTTVGAICSGIRAL--------P 1008

  Fly  1128 ASTFGQDPGMLMVLCDLKTGTNDTVELTVSSSKLNDPQLPVAVGLLGELLSFRQLNGIQRRKELE 1192
            |:.......:|::|||..:.....||:.||.|...|  ||             ..:.||     .
Mouse  1009 ATRAAAHDRLLLLLCDRASSGASAVEVAVSFSPARD--LP-------------DSSLIQ-----S 1053

  Fly  1193 LQHAKLAALT---------SIVEVKLETARVADGSGHSLLIGVLCGVFIVLVGFSVFISLYWKQR 1248
            ..||.:||:|         ::.|||:||. |..||...||:.|||.||.||....|.|.::|.::
Mouse  1054 TAHAIVAAITQRGNSSLLLAVTEVKVETV-VMGGSSTGLLVPVLCSVFSVLWLACVVICVWWTRK 1117

  Fly  1249 LAYRTSSGMNLTPSLDALRHEEEKSNNLQNEENLRRYTNPLKGSTSSLRAATGMEL--------- 1304
                              |.:|.:.:.|..:|:......||....:.:....|..|
Mouse  1118 ------------------RRKERERSRLPRDESANNQWAPLNPIRNPIERPGGSGLGTGGHKDIL 1164

  Fly  1305 ----SLNPAPELAASAASSSALH 1323
                :..|.|..|..|....|.|
Mouse  1165 YQCKNFTPPPRRAGEALPGPAGH 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	34/81 (42%)
		DSL	220..282	CDD:279722	29/61 (48%)
		EGF_CA	350..388	CDD:238011	20/37 (54%)
		EGF_CA	490..526	CDD:238011	19/35 (54%)
		EGF_CA	610..645	CDD:238011	20/34 (59%)
		EGF_CA	647..683	CDD:238011	19/35 (54%)
		EGF_CA	798..833	CDD:238011	19/72 (26%)
		EGF_CA	879..913	CDD:238011	18/33 (55%)
		EGF_CA	916..952	CDD:238011	21/35 (60%)
		VWC_out	<993..1053	CDD:214565	19/60 (32%)
Jag2	XP_011242300.1	MNNL	28..103	CDD:369454	34/81 (42%)
		DSL	185..247	CDD:366627	29/61 (48%)
		EGF_CA	314..352	CDD:238011	20/37 (54%)
		EGF	358..388	CDD:333761	17/91 (19%)
		EGF_CA	392..428	CDD:238011	19/35 (54%)
		EGF_CA	430..466	CDD:238011	17/79 (22%)
		EGF_CA	468..503	CDD:238011	20/34 (59%)
		EGF_CA	507..541	CDD:238011	19/33 (58%)
		EGF_CA	543..578	CDD:238011	17/34 (50%)
		EGF_CA	643..678	CDD:238011	11/34 (32%)
		EGF_CA	683..716	CDD:238011	8/32 (25%)
		EGF	723..753	CDD:333761	10/29 (34%)
		EGF_CA	764..794	CDD:238011	6/29 (21%)
		EGF_CA	<804..831	CDD:238011	17/26 (65%)
		EGF_CA	834..870	CDD:238011	21/35 (60%)
		VWC_out	879..950	CDD:214565	22/91 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834956
Domainoid	1	1.000	123	1.000	Domainoid score	I5569
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	722	1.000	Inparanoid score	I628
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45993
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	1	1.000	-	-		FOG0003067
OrthoInspector	1	1.000	-	-		otm42318
orthoMCL	1	0.900	-	-		OOG6_105778
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4751
SonicParanoid	1	1.000	-	-		X2046
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.700