DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ser and Jag1

DIOPT Version :9

Sequence 1:NP_001287558.1 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster
Sequence 2:NP_038850.1 Gene:Jag1 / 16449 MGIID:1095416 Length:1218 Species:Mus musculus


Alignment Length:1415 Identity:476/1415 - (33%)
Similarity:662/1415 - (46%) Gaps:344/1415 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 LIALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCG---MPAELRATKTIGCSPCTTAFRL 129
            |:||:..|......|:|.||||||.:.|.|..|.||.|||   .|.:.:.|:    ..|.|.|::
Mouse    17 LLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGVRNPGDRKCTR----DECDTYFKV 77

  Fly   130 CLKEYQTTEQGASISTG--CSFGNATTKILGGSSFVL-----SDPGVGAIVLPFTFRWTKSFTLI 187
            ||||||     :.::.|  ||||:.:|.::||::|.|     :|.  ..|||||:|.|.:|:||:
Mouse    78 CLKEYQ-----SRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDR--NRIVLPFSFAWPRSYTLL 135

  Fly   188 LQALDMYN-TSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCTT 251
            ::|.|..| |..||:  :||:.|:||:|.||.:|:||......|...|::||.|...||...|..
Mouse   136 VEAWDSSNDTIQPDS--IIEKASHSGMINPSRQWQTLKQNTGIAHFEYQIRVTCDDHYYGFGCNK 198

  Fly   252 FCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLCN 316
            |||||||.||||||...|.|.|:.||.|.:|.:|||:.||.|.||.|..||:|.|:.||:|..|:
Mouse   199 FCRPRDDFFGHYACDQNGNKTCMEGWMGPDCNKAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCD 263

  Fly   317 ECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEG 381
            :|:.:|||.||:|| ..|:|:|:|||||.|||:|||:||||:||.:.|||.||.||||:|:|.||
Mouse   264 KCIPHPGCVHGTCN-EPWQCLCETNWGGQLCDKDLNYCGTHQPCLNRGTCSNTGPDKYQCSCPEG 327

  Fly   382 LSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPE 446
            .||..|||.||.|.:.||.|.|:|.            .||.|                       
Mouse   328 YSGPNCEIAEHACLSDPCHNRGSCK------------ETSSG----------------------- 357

  Fly   447 GQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGG 511
                                       |.|:|:.|||||||..|||:|:...|.|||||.||:.|
Mouse   358 ---------------------------FECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNG 395

  Fly   512 FRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSL 576
            |:|.|||:|.|..||:|.|||||.                                         
Mouse   396 FKCVCPPQWTGKTCQLDANECEAK----------------------------------------- 419

  Fly   577 AIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGATCIDLVNDYRCACASGFKG 641
               ||:||:.|:|...|:.|.|..||.|..|..|::||:|||:|.|:|.||||.|||.|..|:.|
Mouse   420 ---PCVNARSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAG 481

  Fly   642 RDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLEG-HCLNTPEG 705
            ..||.||||||::||.|||.|.:.:.:|.|:||.|:||:||:...:.|.|:||..| .|.|....
Mouse   482 DHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASD 546

  Fly   706 YYCHCPPDRAGKHCEQLRPLCSQPPCN--EGCFANVSLATSATTTTTTTTTATTTRKMAKPSGL- 767
            |:|.||.|..||:|..|:..|....|.  :.|  .|::|::.|                 |.|: 
Mouse   547 YFCKCPEDYEGKNCSHLKDHCRTTTCEVIDSC--TVAMASNDT-----------------PEGVR 592

  Fly   768 -----PCSGHGSCEMSDVGTF-CKCHVGHTGTFCEHNLNECSPNPCRNGGICLDG---------D 817
                 .|..||.|:....|.| |.|:.|.|||:|..|:|:|..|||:|||.|:||         |
Mouse   593 YISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCKNGGTCIDGVNSYKCICSD 657

  Fly   818 G-----------------------------DFTCECMSGWTGKRCSERATGCYAGQCQNGGTC-- 851
            |                             ||.|:|.:||.||.|..|.:.|....|.|||||  
Mouse   658 GWEGAHCENNINDCSQNPCHYGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYD 722

  Fly   852 --------MPG---------APDKALQPH----------------CRCAPGWTGLFCAEAIDQCR 883
                    .||         |.:.:..|:                |.|..||.|..|.:..:.|.
Mouse   723 EVDTFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGDSFTCVCKEGWEGPICTQNTNDCS 787

  Fly   884 GQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICPPGRHG 948
            ..||:|.|||..|..|:||.||.||:|||||||:|||...||..||||:|.|.||.||||||..|
Mouse   788 PHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYQCICPPGHSG 852

  Fly   949 LRCEILLSDPKSACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWC 1013
            .:|               :.:|..:.:...:    :.|.|...||: ||.|.|.||...|:.:||
Mouse   853 AKC---------------HEVSGRSCITMGR----VILDGAKWDDD-CNTCQCLNGRVACSKVWC 897

  Fly  1014 GLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSS 1078
            |...|    .|.||.|   .|...:.|:|.|.:.|...||...|:||:....        |.|:.
Mouse   898 GPRPC----RLHKSHN---ECPSGQSCIPVLDDQCFVRPCTGVGECRSSSLQ--------PVKTK 947

  Fly  1079 CWPNQAVVNENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGMLMVLCD 1143
            | .:.:...:|||.:|.....|.:..|.:.|.:||.:|.|   .::|..::.:.     :.:.|:
Mouse   948 C-TSDSYYQDNCANITFTFNKEMMSPGLTTEHICSELRNL---NILKNVSAEYS-----IYIACE 1003

  Fly  1144 LKTGTNDTVELTVSSSKLNDPQLPV--AVGLLGELLSFRQLNGIQRRKELELQHAKLAALTSIVE 1206
            .....|:.:.:.:|:..:.|...||  ....:.:|:|.|..|.              :.:.::.|
Mouse  1004 PSLSANNEIHVAISAEDIRDDGNPVKEITDKIIDLVSKRDGNS--------------SLIAAVAE 1054

  Fly  1207 VKLETARVADGSGHSLLIGVLCGVFIVLVGFSVFISLYWKQRLAYRTSSGMNLTPSLDALRHEEE 1271
            |:::...:.:.:  ..|:.:|..|..|.....:..:.||..|...:.||..:..|       |:.
Mouse  1055 VRVQRRPLKNRT--DFLVPLLSSVLTVAWVCCLVTAFYWCVRKRRKPSSHTHSAP-------EDN 1110

  Fly  1272 KSNNLQNEENLRRYTNPLKGSTSSLRAATGMELSLNPAP----ELAASAASSSALHRS------- 1325
            .:||::  |.|.:..||::            :...|..|    |...|..|....|.|       
Mouse  1111 TTNNVR--EQLNQIKNPIE------------KHGANTVPIKDYENKNSKMSKIRTHNSEVEEDDM 1161

  Fly  1326 -----------QPLFPPCDFERELDSSTGLKQAHKRSSQILLHKTQNSDM 1364
                       ||::...|.|.:..|.|..|..:      ..:|..|.|:
Mouse  1162 DKHQQKVRFAKQPVYTLVDREEKAPSGTPTKHPN------WTNKQDNRDL 1205

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SerNP_001287558.1 MNNL 83..161 CDD:284966 34/82 (41%)
DSL 220..282 CDD:279722 30/61 (49%)
EGF_CA 350..388 CDD:238011 24/37 (65%)
EGF_CA 490..526 CDD:238011 20/35 (57%)
EGF_CA 610..645 CDD:238011 19/34 (56%)
EGF_CA 647..683 CDD:238011 20/35 (57%)
EGF_CA 798..833 CDD:238011 22/72 (31%)
EGF_CA 879..913 CDD:238011 17/33 (52%)
EGF_CA 916..952 CDD:238011 21/35 (60%)
VWC_out <993..1053 CDD:214565 21/59 (36%)
Jag1NP_038850.1 MNNL 32..106 CDD:284966 34/82 (41%)
DSL 167..229 CDD:279722 30/61 (49%)
Important for interaction with NOTCH1. /evidence=ECO:0000250 199..207 7/7 (100%)
EGF_CA 296..334 CDD:238011 24/37 (65%)
EGF 340..370 CDD:278437 16/91 (18%)
EGF_CA 374..410 CDD:238011 20/35 (57%)
EGF_CA 412..447 CDD:238011 18/78 (23%)
EGF_CA 450..485 CDD:238011 19/34 (56%)
EGF_CA 487..523 CDD:238011 20/35 (57%)
EGF_CA 525..560 CDD:238011 14/34 (41%)
EGF_CA 629..665 CDD:238011 14/35 (40%)
EGF_CA 667..702 CDD:238011 8/34 (24%)
EGF_CA <714..740 CDD:238011 8/25 (32%)
EGF 748..777 CDD:278437 5/28 (18%)
EGF_CA 782..817 CDD:238011 17/34 (50%)
EGF_CA 820..855 CDD:238011 21/34 (62%)
VWC_out 863..930 CDD:214565 24/78 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1181..1218 7/31 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167834958
Domainoid 1 1.000 123 1.000 Domainoid score I5569
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H180
Inparanoid 1 1.050 722 1.000 Inparanoid score I628
Isobase 1 0.950 - 0 Normalized mean entropy S3686
OMA 1 1.010 - - QHG45993
OrthoDB 1 1.010 - - D197806at33208
OrthoFinder 1 1.000 - - FOG0003067
OrthoInspector 1 1.000 - - otm42318
orthoMCL 1 0.900 - - OOG6_105778
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2046
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.620

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