DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ser and jag2b

DIOPT Version :10

Sequence 1:NP_524527.3 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster
Sequence 2:NP_571937.1 Gene:jag2b / 140422 ZFINID:ZDB-GENE-011128-3 Length:1254 Species:Danio rerio


Alignment Length:1441 Identity:483/1441 - (33%)
Similarity:660/1441 - (45%) Gaps:333/1441 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 IALILILLVHKIS-AAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGC--SPCTTAFRLC 130
            ||.:|:.:..|:| ::|.|||:::.:.|.|..|.:|.||.   ..|.::...|  ..|.|.|::|
Zfish    13 IACLLLTMWTKVSQSSGYFELQLIAVENVNGELWDGECCD---STRNSQDQRCVRDECDTYFKVC 74

  Fly   131 LKEYQ----TTEQGASISTGCSFGNATTKILGGSSFVL----------SDPGVGAIVLPFTFRWT 181
            |||||    ||.|       |:||:.:|.:|||:.|..          ||  ||.|::||.|.|.
Zfish    75 LKEYQSEVTTTGQ-------CTFGSGSTDVLGGNIFSFKTAKNSPSKTSD--VGKIIIPFHFAWP 130

  Fly   182 KSFTLILQALDMYNTSYPDA-ERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYY 245
            :|:||||:|.|..|::..:. |.|||...::.::.|...|:::.|.|..|.|.||:||:|...||
Zfish   131 RSYTLILEAWDWDNSTQNNGEENLIERHIHASMVNPGDHWQSIRHPGITAHIEYRIRVRCDENYY 195

  Fly   246 NTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGW 310
            .:.|...||||||.||||.|...|..:||:||.|.:|..||||.||:.:||.|..||||:|..||
Zfish   196 GSKCNKQCRPRDDYFGHYRCDPSGNIVCLDGWMGEDCRTAICKQGCNLIHGGCAVPGECKCNYGW 260

  Fly   311 RGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYR 375
            :|..|:||:.||||.||:| ...|:|.|:.||||:|||:|||:||||.||.:||||.|:.||:|.
Zfish   261 QGQFCDECLPYPGCLHGTC-VMPWQCTCEKNWGGLLCDKDLNYCGTHHPCVNGGTCMNSEPDEYN 324

  Fly   376 CTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSL 440
            |.|.||.||:.|||.||.|.:.||.|||||                                   
Zfish   325 CACPEGYSGKNCEIAEHACVSNPCANGGTC----------------------------------- 354

  Fly   441 DHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTC 505
             |..|.|                          |.|.|..||.||||..::||||..||..||||
Zfish   355 -HEVPTG--------------------------FECHCPPGWEGPTCAKDMDECASSPCAQGGTC 392

  Fly   506 IDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSA 570
            |||..||.|.|||:|.|..||:|.|||                     :|.              
Zfish   393 IDLENGFECVCPPQWVGKTCQIDANEC---------------------MGK-------------- 422

  Fly   571 VASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGATCIDLVN-DYRCA 634
                     ||:||..|:|..|.:.|.|.:||.|..|..||:.|.|||:|||||.:||: .|.|.
Zfish   423 ---------PCVNAHSCKNMIGGYHCDCFQGWAGQNCDINLNGCHGQCQNGATCKELVHGGYHCQ 478

  Fly   635 CASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCE-EAKEN---CTPSPCL 695
            |.:||.|..||...::||:.||:|||.|..::..|.|.||..|:|.||| |:..:   |.|:||.
Zfish   479 CPAGFVGLHCEVSRNKCASGPCQNGGRCHVILDSFVCECPSNYAGMLCEVESLSHPNPCEPNPCQ 543

  Fly   696 E-GHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTR 759
            . ..|.:.|..:||.||.|..||.||..:..|...||        .:..|.|....:.::....|
Zfish   544 NTALCYSLPGDFYCACPEDYEGKTCENRKDHCKMTPC--------QVIDSCTIAVASNSSDGGVR 600

  Fly   760 KMAKPSGLPCSGHGSCEMSDVGTF-CKCHVGHTGTFCEHNLNECSPNPCRNGGICLDG------- 816
            .:   :...|..||.|.....|.| |.|.:|.|||:|..|:|:|..|||||||.|:||       
Zfish   601 HI---NSNVCGPHGRCISQPGGNFTCTCELGFTGTYCHENVNDCVSNPCRNGGTCIDGISSFQCF 662

  Fly   817 --DG-----------------------------DFTCECMSGWTGKRCSERATGCYAGQCQNGGT 850
              ||                             ||.|||.:||.||.|..|.:.|.:..|.||||
Zfish   663 CPDGWEGDLCSINVNECSRSPCKNGGHCVDLVNDFYCECANGWKGKTCHSRESQCDSSTCSNGGT 727

  Fly   851 CM-----------PG--------------APDKALQP----------HCRCAPGWTGLFCAEAID 880
            |.           ||              |....|..          .|.|..||.|..||:..:
Zfish   728 CYDHGDAFRCACPPGWEGSTCNTAKNSTCASGPCLNGGTCVGGGDTFTCICKDGWEGATCAQNTN 792

  Fly   881 QCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICPPG 945
            .|...||:|||.|..|..||||.||.||:|||||||::||...||..||||:|.|.|:.|:||.|
Zfish   793 DCNPHPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGFRCVCPLG 857

  Fly   946 RHGLRCEILLSDPKSACQNASNTISPYTALN--RSQNWLDIALTGRTEDDENCNACVCENGTSRC 1008
            |.|.:|:..:...|: |.        |..|.  ....|           :|.||.|.|.||...|
Zfish   858 RTGPQCQEFIGIGKT-CH--------YAGLQFPHGSRW-----------EEECNTCQCVNGKVEC 902

  Fly  1009 TNLWCGLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRL 1073
            |.:.||...|  :.|.:....|. .|.....|:.....||||.||:..|.|.:.|     .||.|
Zfish   903 TKVVCGRKPC--LLPGTPGRELH-YCPGGRECLEHNFLTCLSPPCHQWGFCSSPE-----TPPTL 959

  Fly  1074 PAKSSCWPNQAVVNENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGML 1138
            ..|  |.||...::::|||:|::...:::..|.:||.:||.:|.:.|.:.:.|...        |
Zfish   960 QTK--CEPNSVYLDKSCARITLIFNRDKLPTGTTVENVCSELRYMPATRSLAKDHK--------L 1014

  Fly  1139 MVLCDLKTGTNDTVELTVSSSKLNDP---QLPVAVGLLGELLSFRQLNGIQRRKELELQHAKLAA 1200
            :|||||.....|.||:.:|......|   |:..|...:...||.|..:.:               
Zfish  1015 LVLCDLSYKNQDAVEVAISFQHDEQPSHSQIQEAASTIVSTLSKRHNSTV--------------- 1064

  Fly  1201 LTSIVEVKLE---TARVADGSGHSLLIGVLCGVFIVLVGFSVFISLYWKQRLAYRTSSGMNLTPS 1262
            :.:::|||:|   |::..|     .|:.|||.|..||..|.|.:.::|.::              
Zfish  1065 MLAVIEVKVEMPVTSQPVD-----YLVPVLCVVLCVLWVFCVIVCVWWTRK-------------- 1110

  Fly  1263 LDALRHEEEKSNNLQNEENLRRYTNPLKGST----SSLRAATGMELSLNPAPELAASAASSSALH 1323
               .|.|.|:...:..||::.....||:..|    ...|.|......|..:|:...::.......
Zfish  1111 ---RRKERERRERVPVEESVNNQWEPLRPVTRPQHKDNRDAQFERTKLMGSPDRTCNSGDDEEDM 1172

  Fly  1324 RSQPLFPPCDFERELDSSTGLK---QAHKRSSQILLHKTQNSDM--RKNTVGSLDSPRK-----D 1378
            ....|    :...|...:.|.|   |.:.:|:.    :|:|..:  .::|.||.....|     .
Zfish  1173 EEDEL----ELVEEWCGTEGGKHPVQKYSKSAA----RTKNGLICTTRSTSGSSSPSLKAAYWTG 1229

  Fly  1379 FGKRSINCKSM 1389
            |..:..|||::
Zfish  1230 FSPKDNNCKNV 1240

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SerNP_524527.3 MNNL 83..238 CDD:462222 61/171 (36%)
DSL 220..282 CDD:128366 30/61 (49%)
EGF_CA 350..388 CDD:238011 23/37 (62%)
EGF_CA 490..526 CDD:238011 21/35 (60%)
EGF_CA 610..645 CDD:238011 19/35 (54%)
EGF_CA 647..683 CDD:238011 15/35 (43%)
EGF_CA 690..720 CDD:238011 12/30 (40%)
EGF_CA 798..833 CDD:238011 24/72 (33%)
EGF_CA 879..913 CDD:238011 18/33 (55%)
EGF_CA 916..952 CDD:238011 18/35 (51%)
VWC_out <993..1053 CDD:214565 20/59 (34%)
jag2bNP_571937.1 EGF_CA 493..527 CDD:238011 15/33 (45%)
EGF_CA 535..569 CDD:238011 13/33 (39%)
EGF_CA 637..672 CDD:238011 15/34 (44%)
EGF_CA 675..710 CDD:238011 9/34 (26%)
EGF_CA 718..748 CDD:238011 8/29 (28%)
EGF 756..786 CDD:394967 7/29 (24%)
EGF_CA 790..825 CDD:238011 18/34 (53%)
EGF_CA 828..864 CDD:238011 18/35 (51%)
VWC_out 873..944 CDD:214565 24/92 (26%)
MNNL 28..188 CDD:462222 61/171 (36%)
DSL 170..232 CDD:128366 30/61 (49%)
EGF_CA 299..337 CDD:238011 23/37 (62%)
EGF_CA <346..374 CDD:238011 17/89 (19%)
EGF_CA 377..413 CDD:238011 21/35 (60%)
EGF_CA 415..450 CDD:238011 17/78 (22%)
EGF_CA 458..489 CDD:238011 16/30 (53%)

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