DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and jag2b

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_571937.1	Gene:	jag2b / 140422	ZFINID:	ZDB-GENE-011128-3	Length:	1254	Species:	Danio rerio

Alignment Length:	1441	Identity:	483/1441 - (33%)
Similarity:	660/1441 - (45%)	Gaps:	333/1441 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 IALILILLVHKIS-AAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGC--SPCTTAFRLC 130
            ||.:|:.:..|:| ::|.|||:::.:.|.|..|.:|.||.   ..|.::...|  ..|.|.|::|
Zfish    13 IACLLLTMWTKVSQSSGYFELQLIAVENVNGELWDGECCD---STRNSQDQRCVRDECDTYFKVC 74

  Fly   131 LKEYQ----TTEQGASISTGCSFGNATTKILGGSSFVL----------SDPGVGAIVLPFTFRWT 181
            |||||    ||.|       |:||:.:|.:|||:.|..          ||  ||.|::||.|.|.
Zfish    75 LKEYQSEVTTTGQ-------CTFGSGSTDVLGGNIFSFKTAKNSPSKTSD--VGKIIIPFHFAWP 130

  Fly   182 KSFTLILQALDMYNTSYPDA-ERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYY 245
            :|:||||:|.|..|::..:. |.|||...::.::.|...|:::.|.|..|.|.||:||:|...||
Zfish   131 RSYTLILEAWDWDNSTQNNGEENLIERHIHASMVNPGDHWQSIRHPGITAHIEYRIRVRCDENYY 195

  Fly   246 NTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGW 310
            .:.|...||||||.||||.|...|..:||:||.|.:|..||||.||:.:||.|..||||:|..||
Zfish   196 GSKCNKQCRPRDDYFGHYRCDPSGNIVCLDGWMGEDCRTAICKQGCNLIHGGCAVPGECKCNYGW 260

  Fly   311 RGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYR 375
            :|..|:||:.||||.||:| ...|:|.|:.||||:|||:|||:||||.||.:||||.|:.||:|.
Zfish   261 QGQFCDECLPYPGCLHGTC-VMPWQCTCEKNWGGLLCDKDLNYCGTHHPCVNGGTCMNSEPDEYN 324

  Fly   376 CTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSL 440
            |.|.||.||:.|||.||.|.:.||.|||||
Zfish   325 CACPEGYSGKNCEIAEHACVSNPCANGGTC----------------------------------- 354

  Fly   441 DHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTC 505
             |..|.|                          |.|.|..||.||||..::||||..||..||||
Zfish   355 -HEVPTG--------------------------FECHCPPGWEGPTCAKDMDECASSPCAQGGTC 392

  Fly   506 IDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSA 570
            |||..||.|.|||:|.|..||:|.|||                     :|.
Zfish   393 IDLENGFECVCPPQWVGKTCQIDANEC---------------------MGK-------------- 422

  Fly   571 VASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGATCIDLVN-DYRCA 634
                     ||:||..|:|..|.:.|.|.:||.|..|..||:.|.|||:|||||.:||: .|.|.
Zfish   423 ---------PCVNAHSCKNMIGGYHCDCFQGWAGQNCDINLNGCHGQCQNGATCKELVHGGYHCQ 478

  Fly   635 CASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCE-EAKEN---CTPSPCL 695
            |.:||.|..||...::||:.||:|||.|..::..|.|.||..|:|.||| |:..:   |.|:||.
Zfish   479 CPAGFVGLHCEVSRNKCASGPCQNGGRCHVILDSFVCECPSNYAGMLCEVESLSHPNPCEPNPCQ 543

  Fly   696 E-GHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTR 759
            . ..|.:.|..:||.||.|..||.||..:..|...||        .:..|.|....:.::....|
Zfish   544 NTALCYSLPGDFYCACPEDYEGKTCENRKDHCKMTPC--------QVIDSCTIAVASNSSDGGVR 600

  Fly   760 KMAKPSGLPCSGHGSCEMSDVGTF-CKCHVGHTGTFCEHNLNECSPNPCRNGGICLDG------- 816
            .:   :...|..||.|.....|.| |.|.:|.|||:|..|:|:|..|||||||.|:||
Zfish   601 HI---NSNVCGPHGRCISQPGGNFTCTCELGFTGTYCHENVNDCVSNPCRNGGTCIDGISSFQCF 662

  Fly   817 --DG-----------------------------DFTCECMSGWTGKRCSERATGCYAGQCQNGGT 850
              ||                             ||.|||.:||.||.|..|.:.|.:..|.||||
Zfish   663 CPDGWEGDLCSINVNECSRSPCKNGGHCVDLVNDFYCECANGWKGKTCHSRESQCDSSTCSNGGT 727

  Fly   851 CM-----------PG--------------APDKALQP----------HCRCAPGWTGLFCAEAID 880
            |.           ||              |....|..          .|.|..||.|..||:..:
Zfish   728 CYDHGDAFRCACPPGWEGSTCNTAKNSTCASGPCLNGGTCVGGGDTFTCICKDGWEGATCAQNTN 792

  Fly   881 QCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICPPG 945
            .|...||:|||.|..|..||||.||.||:|||||||::||...||..||||:|.|.|:.|:||.|
Zfish   793 DCNPHPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGFRCVCPLG 857

  Fly   946 RHGLRCEILLSDPKSACQNASNTISPYTALN--RSQNWLDIALTGRTEDDENCNACVCENGTSRC 1008
            |.|.:|:..:...|: |.        |..|.  ....|           :|.||.|.|.||...|
Zfish   858 RTGPQCQEFIGIGKT-CH--------YAGLQFPHGSRW-----------EEECNTCQCVNGKVEC 902

  Fly  1009 TNLWCGLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRL 1073
            |.:.||...|  :.|.:....|. .|.....|:.....||||.||:..|.|.:.|     .||.|
Zfish   903 TKVVCGRKPC--LLPGTPGRELH-YCPGGRECLEHNFLTCLSPPCHQWGFCSSPE-----TPPTL 959

  Fly  1074 PAKSSCWPNQAVVNENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGML 1138
            ..|  |.||...::::|||:|::...:::..|.:||.:||.:|.:.|.:.:.|...        |
Zfish   960 QTK--CEPNSVYLDKSCARITLIFNRDKLPTGTTVENVCSELRYMPATRSLAKDHK--------L 1014

  Fly  1139 MVLCDLKTGTNDTVELTVSSSKLNDP---QLPVAVGLLGELLSFRQLNGIQRRKELELQHAKLAA 1200
            :|||||.....|.||:.:|......|   |:..|...:...||.|..:.:
Zfish  1015 LVLCDLSYKNQDAVEVAISFQHDEQPSHSQIQEAASTIVSTLSKRHNSTV--------------- 1064

  Fly  1201 LTSIVEVKLE---TARVADGSGHSLLIGVLCGVFIVLVGFSVFISLYWKQRLAYRTSSGMNLTPS 1262
            :.:::|||:|   |::..|     .|:.|||.|..||..|.|.:.::|.::
Zfish  1065 MLAVIEVKVEMPVTSQPVD-----YLVPVLCVVLCVLWVFCVIVCVWWTRK-------------- 1110

  Fly  1263 LDALRHEEEKSNNLQNEENLRRYTNPLKGST----SSLRAATGMELSLNPAPELAASAASSSALH 1323
               .|.|.|:...:..||::.....||:..|    ...|.|......|..:|:...::.......
Zfish  1111 ---RRKERERRERVPVEESVNNQWEPLRPVTRPQHKDNRDAQFERTKLMGSPDRTCNSGDDEEDM 1172

  Fly  1324 RSQPLFPPCDFERELDSSTGLK---QAHKRSSQILLHKTQNSDM--RKNTVGSLDSPRK-----D 1378
            ....|    :...|...:.|.|   |.:.:|:.    :|:|..:  .::|.||.....|     .
Zfish  1173 EEDEL----ELVEEWCGTEGGKHPVQKYSKSAA----RTKNGLICTTRSTSGSSSPSLKAAYWTG 1229

  Fly  1379 FGKRSINCKSM 1389
            |..:..|||::
Zfish  1230 FSPKDNNCKNV 1240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	31/83 (37%)
		DSL	220..282	CDD:279722	30/61 (49%)
		EGF_CA	350..388	CDD:238011	23/37 (62%)
		EGF_CA	490..526	CDD:238011	21/35 (60%)
		EGF_CA	610..645	CDD:238011	19/35 (54%)
		EGF_CA	647..683	CDD:238011	15/35 (43%)
		EGF_CA	798..833	CDD:238011	24/72 (33%)
		EGF_CA	879..913	CDD:238011	18/33 (55%)
		EGF_CA	916..952	CDD:238011	18/35 (51%)
		VWC_out	<993..1053	CDD:214565	20/59 (34%)
jag2b	NP_571937.1	MNNL	28..101	CDD:284966	30/82 (37%)
		DSL	170..232	CDD:279722	30/61 (49%)
		EGF_CA	299..337	CDD:238011	23/37 (62%)
		EGF_CA	<346..374	CDD:238011	17/89 (19%)
		EGF_CA	377..413	CDD:238011	21/35 (60%)
		EGF_CA	415..450	CDD:238011	17/78 (22%)
		EGF_CA	458..489	CDD:238011	16/30 (53%)
		EGF_CA	493..527	CDD:238011	15/33 (45%)
		EGF_CA	535..569	CDD:238011	13/33 (39%)
		EGF_CA	637..672	CDD:238011	15/34 (44%)
		EGF_CA	675..710	CDD:238011	9/34 (26%)
		EGF	756..786	CDD:278437	7/29 (24%)
		EGF_CA	790..825	CDD:238011	18/34 (53%)
		EGF_CA	828..864	CDD:238011	18/35 (51%)
		VWC_out	873..944	CDD:214565	24/92 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578046
Domainoid	1	1.000	128	1.000	Domainoid score	I5260
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	709	1.000	Inparanoid score	I633
OMA	1	1.010	-	-		QHG45993
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	1	1.000	-	-		FOG0003067
OrthoInspector	1	1.000	-	-		otm24795
orthoMCL	1	0.900	-	-		OOG6_105778
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2046
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.670