DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and jag1a

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_005168261.1	Gene:	jag1a / 140421	ZFINID:	ZDB-GENE-011128-2	Length:	1253	Species:	Danio rerio

Alignment Length:	1448	Identity:	475/1448 - (32%)
Similarity:	656/1448 - (45%)	Gaps:	363/1448 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SACNLIALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCG---MPAELRATKTIGCSPCTT 125
            :|.:...|:..|.:....|:|:||:::|.:.|.|..|.||.||.   .|||    ::.....|.|
Zfish    10 AALSAHVLLRCLWMRVCEASGHFEMQVLSMQNVNGELQNGACCDGARDPAE----RSCAADQCDT 70

  Fly   126 AFRLCLKEYQTTEQGASISTG--CSFGNATTKILGGSSFVL------SDPGVGAIVLPFTFRWTK 182
            .||:||||||     :.:|:|  ||:|:.:|.::||::|.:      :|.  ..|||||:|.|.:
Zfish    71 FFRVCLKEYQ-----SRVSSGGPCSYGSGSTPVIGGNTFSVKPLDQTNDK--TRIVLPFSFAWPR 128

  Fly   183 SFTLILQALDMYNTSYPDA--ERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYY 245
            |:|||::|||..|.|...:  .::||:...||:|.|:.:|:.|.|.|..|:..|::||.|...|:
Zfish   129 SYTLIVEALDFNNDSSTGSINGQVIEKAVQSGMINPNRQWQVLKHNGPVAQFQYQIRVTCDEHYF 193

  Fly   246 NTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGW 310
            ...|..|||||||.||||.|...|.|.||.||.|..|..||||.||...||.|..||.|.|..||
Zfish   194 GFGCNKFCRPRDDFFGHYTCDHNGNKTCLEGWAGPECNTAICKQGCSIEHGSCKVPGNCRCLYGW 258

  Fly   311 RGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYR 375
            :|..|::|:.:|||.||:|. ..|:|:|||||||.|||:|||.|||.:||.:||||.||.||||.
Zfish   259 QGEYCDQCIPHPGCVHGTCI-EPWQCLCDTNWGGQLCDKDLNTCGTLQPCLNGGTCSNTGPDKYH 322

  Fly   376 CTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSL 440
            |.|.||.||:.||..::.|.:.||.|||.|.                 .|::|
Zfish   323 CACPEGYSGQNCERADNACLSEPCLNGGLCV-----------------ESSLG------------ 358

  Fly   441 DHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTC 505
                                             |.|.||||||||:|.||.|:|:..||.|.|.|
Zfish   359 ---------------------------------FECQCAAGWTGPSCNINEDDCSPNPCNHSGVC 390

  Fly   506 IDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSA 570
            :||:.||:|.||.:|.|..|.:|.||||.
Zfish   391 VDLVDGFKCICPVQWTGKTCLIDANECEE------------------------------------ 419

  Fly   571 VASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGATCIDLVNDYRCAC 635
                    .||:||..|||..|.:.|.|..||.|..|..|::||.|||.||..|.||||.|||.|
Zfish   420 --------SPCVNAHSCRNLIGGYFCECLPGWTGQNCDINVNDCHGQCLNGGLCKDLVNGYRCVC 476

  Fly   636 ASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLEG-HC 699
            |:||.|..||.|:||||:.||.|||.|.|.:..|.|:||.|:||:.|:...:.|...||..| .|
Zfish   477 AAGFAGDRCERDVDECASRPCLNGGRCQDTLNGFQCLCPPGFSGATCQLDLDYCESGPCQNGAQC 541

  Fly   700 LNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTRKMAKP 764
            .:....|||.||.|..||:|.||:..|...||        .:..|.|....:.:|         |
Zfish   542 FSLASDYYCKCPEDYEGKNCSQLKDHCLITPC--------QVIDSCTVAVVSNST---------P 589

  Fly   765 SGL------PCSGHGSCEMSD--VGTF-CKCHVGHTGTFCEHNLNECSPNPCRNGGICLD----- 815
            .||      .|..||.|....  .|.| |.|..|.|||:|..|:|:|..:||.:||.|:|
Zfish   590 GGLRLISSSVCGPHGRCRSHSHAGGHFSCDCQDGFTGTYCHENINDCESSPCLSGGTCIDKINAY 654

  Fly   816 ----GDG-----------------------------DFTCECMSGWTGKRCSERATGCYAGQCQN 847
                .||                             ||.|||.:||.||.|..|.:.|....|.|
Zfish   655 QCICADGWEGPNCETNIDDCRTNPCRDRGVCRDLVNDFYCECENGWKGKTCHSRESQCDEDTCNN 719

  Fly   848 GGT-----------CMPG--------APDKALQPH----------------CRCAPGWTGLFCAE 877
            |||           |.||        |.:.:..|:                |.|..||.|..|::
Zfish   720 GGTCSDEGDSFKCLCSPGWEGATCNIAKNSSCLPNPCENGATCVVTGDGFTCVCKEGWEGPTCSQ 784

  Fly   878 AIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCIC 942
            ..:.|..|||:|.|||..|..|:||.||.||:|||||||:|||...||..|:||:|.|.||.|:|
Zfish   785 NSNDCNPQPCYNSGTCVDGDNWYRCECASGFAGPDCRININECQSSPCAFGSTCVDEINGYRCLC 849

  Fly   943 PPGRHGLRCEILLSDPKSACQNASNTISPYTALNRSQNWLDIALTGRTEDD-----ENCNACVCE 1002
            ||||.|.||:.:...|   |                      .:.||...|     |:||.|.|.
Zfish   850 PPGRTGPRCQEVTGRP---C----------------------VIGGRIAVDGAKWAEDCNTCYCH 889

  Fly  1003 NGTSRCTNLWCGLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRR 1067
            .|...||.|:||...|..:      .:..|.|...::|||...|.|...||:.:|:|       .
Zfish   890 KGIVTCTKLFCGPKACRML------GSGRGDCPTGQMCVPVRDEQCFVKPCSSQGEC-------F 941

  Fly  1068 VAPPRLPAKSSCWP-------NQAVVNENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIK 1125
            |.|  ..::..||.       .....:.:||.:|.....:.:.:|.:||.:|..:|.|   .:.|
Zfish   942 VKP--CSSQGECWSAHRPTVRTHCQPDSHCANVTFTFNKDTMPQGVTVEQVCRELRHL---YVTK 1001

  Fly  1126 KPASTFGQDPGMLMVLCDLKTGTNDTVELTVSSSKLNDPQLPVAVGLLGELLSFRQLNGIQRR-- 1188
            ...|.|.     :.|.|:|.:..::.:.:.:..::                      |||..|
Zfish  1002 NVTSEFS-----ISVSCELSSAASNEIHVAIHVTE----------------------NGIHGRVP 1039

  Fly  1189 -KE-------LELQH-AKLAALTSIVEVKLETARVADGSGH---SLLIGVLCGVFIVLVGFSVFI 1241
             ||       |..:| |..:.:.||.||:::..:..:.:..   .||:.|:..::::.:. |||:
Zfish  1040 VKEITDNIIDLVSKHSANSSVIGSIAEVRVQRKQPQNPNVDYMVPLLVSVVTAIWVLALA-SVFL 1103

  Fly  1242 SLYW------KQRLAYRTSSGMNLTPSLDALRHEEEKSNNLQNEENLRRYTNPLKGSTSSLRAAT 1300
               |      ||     :||...:.|:......||..:||.:  |:|.:..|.::.:.|: .:..
Zfish  1104 ---WCIRHHRKQ-----SSSATAINPTSPFSTPEENTANNAR--EHLNQIKNHIEKNASN-GSLP 1157

  Fly  1301 GMELSLNPA-----------PELAASAASSSALHRSQPLFPPCDFERELDSS-TGLKQ----AHK 1349
            |.||..:..           ||..||..........||.:...|.:..|.|: |.:|:    .:|
Zfish  1158 GKELHCDDKNTVNAKIRTQFPESDASRRLQKTRFPHQPAYMLVDRDDRLSSNGTDIKKHPQWTNK 1222

  Fly  1350 RSSQIL--LHKTQNSDMR 1365
            |.::.|  .|:..:|..|
Zfish  1223 RDNRDLESQHRVPDSQHR 1240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	32/82 (39%)
		DSL	220..282	CDD:279722	30/61 (49%)
		EGF_CA	350..388	CDD:238011	24/37 (65%)
		EGF_CA	490..526	CDD:238011	17/35 (49%)
		EGF_CA	610..645	CDD:238011	21/34 (62%)
		EGF_CA	647..683	CDD:238011	19/35 (54%)
		EGF_CA	798..833	CDD:238011	20/72 (28%)
		EGF_CA	879..913	CDD:238011	18/33 (55%)
		EGF_CA	916..952	CDD:238011	21/35 (60%)
		VWC_out	<993..1053	CDD:214565	20/64 (31%)
jag1a	XP_005168261.1	MNNL	29..103	CDD:284966	32/82 (39%)
		DSL	168..230	CDD:279722	30/61 (49%)
		EGF_CA	297..335	CDD:238011	24/37 (65%)
		EGF	341..370	CDD:278437	17/90 (19%)
		EGF_CA	375..410	CDD:238011	17/34 (50%)
		EGF_CA	413..448	CDD:238011	18/78 (23%)
		EGF_CA	451..486	CDD:238011	21/34 (62%)
		EGF_CA	488..524	CDD:238011	19/35 (54%)
		EGF_CA	526..561	CDD:238011	13/34 (38%)
		EGF_CA	632..668	CDD:238011	11/35 (31%)
		EGF_CA	670..705	CDD:238011	9/34 (26%)
		EGF	712..742	CDD:278437	9/29 (31%)
		EGF	751..781	CDD:278437	6/29 (21%)
		EGF_CA	787..820	CDD:238011	18/32 (56%)
		EGF_CA	823..859	CDD:238011	21/35 (60%)
		VWC_out	866..934	CDD:214565	23/95 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578057
Domainoid	1	1.000	101	1.000	Domainoid score	I6876
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	709	1.000	Inparanoid score	I633
OMA	1	1.010	-	-		QHG45993
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	1	1.000	-	-		FOG0003067
OrthoInspector	1	1.000	-	-		otm24795
orthoMCL	1	0.900	-	-		OOG6_105778
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2046
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.670