DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser and FBLN7

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_011508887.1	Gene:	FBLN7 / 129804	HGNCID:	26740	Length:	453	Species:	Homo sapiens

Alignment Length:	412	Identity:	101/412 - (24%)
Similarity:	146/412 - (35%)	Gaps:	127/412 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   428 GRPVRRSSSMRSLDHLRPEGQALNGS-----------SSPGLVS------LGSLQLQQQLAPDFT 475
            |:..|.:..:|   |::....||..|           |.|.|.:      .||..|... ...||
Human    46 GQETRFAEGIR---HMKSRLAALQNSVGRVGPDALPVSCPALNTPADGRKFGSKYLVDH-EVHFT 106

  Fly   476 CD------------CAAG--WTG--PTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDV 524
            |:            |...  |||  |.|. .|.||:..||::||||::.:..:||.|||...|:.
Human   107 CNPGFRLVGPSSVVCLPNGTWTGEQPHCR-GISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNR 170

  Fly   525 CQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRN 589
            ||         |.|..||      ...::.|.:..|                      .|..|..
Human   171 CQ---------HQAQTAA------PEGSVAGDSAFS----------------------RAPRCAQ 198

  Fly   590 QPGSFACICKEGW-----GGVTCAENLDDC--VGQ------CRNGATCIDLVNDYRCACASGFK- 640
            ...:..|.|:.|:     .|.:..:::::|  .||      |.:  .|::....|||.|..|::
Human   199 VERAQHCSCEAGFHLSGAAGDSVCQDVNECELYGQEGRPRLCMH--ACVNTPGSYRCTCPGGYRT 261

  Fly   641 ---GRDCETDIDEC-ATSP-CRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLEGHCL 700
               |:.|| |:||| ...| |..|..|::..|.|.|:.|      .|.|...|.:........|.
Human   262 LADGKSCE-DVDECVGLQPVCPQGTTCINTGGSFQCVSP------ECPEGSGNVSYVKTSPFQCE 319

  Fly   701 NTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTRK-MAKP 764
            ..|      ||.|  .:.|..|....|        |..:||.::..|..|....||.:.. .|.|
Human   320 RNP------CPMD--SRPCRHLPKTIS--------FHYLSLPSNLKTPITLFRMATASAPGRAGP 368

  Fly   765 SGL-------PCSGHGSCEMSD 779
            :.|       ...||...:.||
Human   369 NSLRFGIVGGNSRGHFVMQRSD 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011
		EGF_CA	490..526	CDD:238011	15/35 (43%)
		EGF_CA	610..645	CDD:238011	11/46 (24%)
		EGF_CA	647..683	CDD:238011	12/37 (32%)
		EGF_CA	798..833	CDD:238011
		EGF_CA	879..913	CDD:238011
		EGF_CA	916..952	CDD:238011
		VWC_out	<993..1053	CDD:214565
FBLN7	XP_011508887.1	CCP	81..135	CDD:153056	13/54 (24%)
		EGF_CA	137..172	CDD:238011	15/34 (44%)
		EGF_CA	224..269	CDD:214542	11/46 (24%)
		EGF_CA	270..307	CDD:284955	14/42 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11308
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910