DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and AgaP_AGAP010265

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_319454.4	Gene:	AgaP_AGAP010265 / 1279687	VectorBaseID:	AGAP010265	Length:	660	Species:	Anopheles gambiae

Alignment Length:	677	Identity:	225/677 - (33%)
Similarity:	311/677 - (45%)	Gaps:	117/677 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 ACNLIALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGCSPCTTAFRL 129
            ||..::...:||  |::.:|.||||:....|..|...|..||...|:.:. :.||  .|.|.||.
Mosquito     8 ACIYVSSQFLLL--KVAGSGLFELELRYFQNEKSIDHNEKCCSEKADAQG-RCIG--TCKTRFRA 67

  Fly   130 CLKEYQTTEQGASISTGCSFGNATTKILGGSSF---VLSDPGVG---AIVLPFTFRWTKSFTLIL 188
            |||.||.|   ...::.|:||:..|.:|.|::.   .:|....|   .|..||.|.|...||||:
Mosquito    68 CLKHYQAT---IDTTSPCTFGDVITPVLEGTTLNFTAISGAKEGFTNPIRFPFEFGWPGYFTLII 129

  Fly   189 QAL-DMYNTSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCTTF 252
            :|. |...|:......||...|...::..|.:|....:...:..|.|..||.|...||...|...
Mosquito   130 EAWHDTNETTTRSPGTLISRLSIQRILEVSADWMEDSYNSSHTMIRYAFRVTCDPNYYGAGCANL 194

  Fly   253 CRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLCNE 317
            ||.||||||||.|...|:::            :.|..||  :||.|::|.||.|:.||:||||:|
Mosquito   195 CRKRDDQFGHYTCSPIGERV------------SQCTPGC--LHGHCNKPNECICQSGWKGPLCDE 245

  Fly   318 CMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGL 382
            |..||||.||:|. ..|:|:|...|||:.|:||||:|..|:||.:||||.||....|.|.|..|.
Mosquito   246 CEPYPGCLHGTCK-KPWECICKEGWGGLFCNQDLNYCTNHKPCLNGGTCFNTGQGLYTCQCRPGY 309

  Fly   383 SGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEG 447
            .|.:||:....|:..||.:|.|||            .|..|.::|....|:
Mosquito   310 KGTECELSITSCSDHPCLHGATCT------------STVDGETSMDADGRK-------------- 348

  Fly   448 QALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLI--- 509
                                      :.|.||.||.|..||.....||..|| |.|||:|:.
Mosquito   349 --------------------------YQCHCAKGWMGRHCEREAITCAEKPC-HQGTCVDVTPSS 386

  Fly   510 -------GGFRCECPPEWHGDVCQVDVNECEAPHSA--GIAANALLTTTATAIIGSNLSSTALLA 565
                   ..|||:|||.:.|..|::...||.:.:.|  |.....|:.......:|......
Mosquito   387 SSSSSTSANFRCDCPPGYSGTACEIKSGECYSNYCANGGTWIGMLMCLCPDGFVGDRCEEN---- 447

  Fly   566 ALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQ-CRNGATCIDLVN 629
             :...|.:.      |:|...|.:....|.|.|..|:.|..|.|.:|.|:.: |.||..|.:|.|
Mosquito   448 -VDDCVGNL------CLNGGTCVDADNHFKCQCVPGFIGTHCEEKVDLCLTKPCANGGICTNLEN 505

  Fly   630 DYRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCT---P 691
            ||||.|.:||.|:||..|:|||.::||||||.|::.|..:.|:|..||.|..|||  |:.|   .
Mosquito   506 DYRCQCRAGFTGKDCSADVDECHSAPCRNGGTCINRVNSYQCVCAGGYRGHSCEE--ESATVIQR 568

  Fly   692 SPCLEGHCLNTPEGYYCHCPPDRAGKH 718
            ...:||     .|.::.|..|.:..:|
Mosquito   569 DADIEG-----SEFHHHHHHPQQQQRH 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	29/77 (38%)
		DSL	220..282	CDD:279722	21/61 (34%)
		EGF_CA	350..388	CDD:238011	18/37 (49%)
		EGF_CA	490..526	CDD:238011	16/45 (36%)
		EGF_CA	610..645	CDD:238011	17/35 (49%)
		EGF_CA	647..683	CDD:238011	17/35 (49%)
		EGF_CA	798..833	CDD:238011
		EGF_CA	879..913	CDD:238011
		EGF_CA	916..952	CDD:238011
		VWC_out	<993..1053	CDD:214565
AgaP_AGAP010265	XP_319454.4	MNNL	24..96	CDD:284966	29/77 (38%)
		DSL	162..243	CDD:279722	35/94 (37%)
		EGF_CA	277..315	CDD:238011	18/37 (49%)
		EGF_CA	322..363	CDD:238011	16/92 (17%)
		EGF_CA	447..483	CDD:238011	9/46 (20%)
		EGF_CA	486..520	CDD:238011	16/33 (48%)
		EGF_CA	523..559	CDD:238011	17/35 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15491at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920